Search Results - "Law, K M"

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis by Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, Cox, Thomas R.

“…The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial role in shaping their…”
Get full text

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer by Law, Andrew M K, Valdes-Mora, Fatima, Gallego-Ortega, David

“…The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and…”
Get full text

High-Voltage Generation With Stacked Photodiodes in Standard CMOS Process by Law, M K, Bermak, A

“…In this letter, a method to generate a high open-circuit voltage using integrated photodiodes fabricated in a standard CMOS process is described. In contrast…”
Get full text

Activation of the viral sensor oligoadenylate synthetase 2 (Oas2) prevents pregnancy-driven mammary cancer metastases by Ho, Wing-Hong Jonathan, Law, Andrew M K, Masle-Farquhar, Etienne, Castillo, Lesley E, Mawson, Amanda, O'Bryan, Moira K, Goodnow, Christopher C, Gallego-Ortega, David, Oakes, Samantha R, Ormandy, Christopher J

“…The interferon response can influence the primary and metastatic activity of breast cancers and can interact with checkpoint immunotherapy to modulate its…”
Get full text

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib by Young, Adelaide I J, Law, Andrew M K, Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D, Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F, Fairlie, Walter D, Lucas, Morghan C, Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D Neil, Millar, Ewan K A, O'Toole, Sandra A, Gallego-Ortega, David, Ormandy, Christopher J, Oakes, Samantha R

“…Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell…”
Get full text

MCL-1 antagonism enhances the anti-invasive effects of dasatinib in pancreatic adenocarcinoma by Castillo, Lesley, Young, Adelaide I. J., Mawson, Amanda, Schafranek, Pia, Steinmann, Angela M., Nessem, Danielle, Parkin, Ashleigh, Johns, Amber, Chou, Angela, Law, Andrew M. K., Lucas, Morghan C., Murphy, Kendelle J., Deng, Niantao, Gallego-Ortega, David, Caldon, Catherine E., Timpson, Paul, Pajic, Marina, Ormandy, Christopher J., Oakes, Samantha R.

“…Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. It is phenotypically heterogeneous with a highly unstable genome and…”
Get full text

ELF5 modulates the estrogen receptor cistrome in breast cancer by Piggin, Catherine L, Roden, Daniel L, Law, Andrew M K, Molloy, Mark P, Krisp, Christoph, Swarbrick, Alexander, Naylor, Matthew J, Kalyuga, Maria, Kaplan, Warren, Oakes, Samantha R, Gallego-Ortega, David, Clark, Susan J, Carroll, Jason S, Bartonicek, Nenad, Ormandy, Christopher J

“…Acquired resistance to endocrine therapy is responsible for half of the therapeutic failures in the treatment of breast cancer. Recent findings have implicated…”
Get full text

Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation by Soroosh, Artin, Fang, Kai, Hoffman, Jill M., Law, Ivy K. M., Videlock, Elizabeth, Lokhandwala, Zulfiqar A., Zhao, Jonathan J., Hamidi, Sepehr, Padua, David M., Frey, Mark R., Pothoulakis, Charalabos, Rankin, Carl R.

“…While apoptosis plays a significant role in intestinal homeostasis, it can also be pathogenic if overactive during recovery from inflammation. We recently…”
Get full text

Proteogenomic analysis of Inhibitor of Differentiation 4 (ID4) in basal-like breast cancer by Baker, Laura A, Holliday, Holly, Roden, Daniel, Krisp, Christoph, Wu, Sunny Z, Junankar, Simon, Serandour, Aurelien A, Mohammed, Hisham, Nair, Radhika, Sankaranarayanan, Geetha, Law, Andrew M K, McFarland, Andrea, Simpson, Peter T, Lakhani, Sunil, Dodson, Eoin, Selinger, Christina, Anderson, Lyndal, Samimi, Goli, Hacker, Neville F, Lim, Elgene, Ormandy, Christopher J, Naylor, Matthew J, Simpson, Kaylene, Nikolic, Iva, O'Toole, Sandra, Kaplan, Warren, Cowley, Mark J, Carroll, Jason S, Molloy, Mark, Swarbrick, Alexander

“…Basal-like breast cancer (BLBC) is a poorly characterised, heterogeneous disease. Patients are diagnosed with aggressive, high-grade tumours and often relapse…”
Get full text

Correction: Loss of miR-24-3p promotes epithelial cell apoptosis and impairs the recovery from intestinal inflammation by Soroosh, Artin, Fang, Kai, Hoffman, Jill M., Law, Ivy K. M., Videlock, Elizabeth, Lokhandwala, Zulfiqar A., Zhao, Jonathan J., Hamidi, Sepehr, Padua, David M., Frey, Mark R., Pothoulakis, Charalabos, Rankin, Carl R.

Get full text

A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation by Oakes, Samantha R, Gallego-Ortega, David, Stanford, Prudence M, Junankar, Simon, Au, Wendy Wing Yee, Kikhtyak, Zoya, von Korff, Anita, Sergio, Claudio M, Law, Andrew M K, Castillo, Lesley E, Allerdice, Stephanie L, Young, Adelaide I J, Piggin, Catherine, Whittle, Belinda, Bertram, Edward, Naylor, Matthew J, Roden, Daniel L, Donovan, Jesse, Korennykh, Alexei, Goodnow, Christopher C, O'Bryan, Moira K, Ormandy, Christopher J

“…We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes…”
Get full text

A Low-Power Energy-Harvesting Logarithmic CMOS Image Sensor With Reconfigurable Resolution Using Two-Level Quantization Scheme by Law, M K, Bermak, A, Shi, C

“…In this brief, a CMOS image sensor that exploits the possibility of reconfiguring pixel photodiodes for energy harvesting for wireless image sensor…”
Get full text

First trimester screening for pre‐eclampsia in Chinese pregnancies: case–control study by Cheng, YKY, Leung, TY, Law, LW, Ting, YH, Law, KM, Sahota, DS

“…Objective To assess the potential of screening for pre‐eclampsia (PE) in a Chinese population. Design Case–control study. Setting Teaching hospital in Hong…”
Get full text

Advancements in 3D Cell Culture Systems for Personalizing Anti-Cancer Therapies by Law, Andrew M K, Rodriguez de la Fuente, Laura, Grundy, Thomas J, Fang, Guocheng, Valdes-Mora, Fatima, Gallego-Ortega, David

“…Over 90% of potential anti-cancer drug candidates results in translational failures in clinical trials. The main reason for this failure can be attributed to…”
Get full text

Mammary Tumor Organoid Culture in Non‐Adhesive Alginate for Luminal Mechanics and High‐Throughput Drug Screening by Fang, Guocheng, Lu, Hongxu, Rodriguez de la Fuente, Laura, Law, Andrew M. K., Lin, Gungun, Jin, Dayong, Gallego‐Ortega, David

“…Mammary tumor organoids have become a promising in vitro model for drug screening and personalized medicine. However, the dependency on the basement membrane…”
Get full text

Single-Cell Transcriptomics in Cancer Immunobiology: The Future of Precision Oncology by Valdes-Mora, Fatima, Handler, Kristina, Law, Andrew M K, Salomon, Robert, Oakes, Samantha R, Ormandy, Christopher J, Gallego-Ortega, David

“…Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular…”
Get full text

Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment by Hassanzadeh-Barforoushi, Amin, Law, Andrew M K, Hejri, Abbas, Asadnia, Mohsen, Ormandy, Christopher J, Gallego-Ortega, David, Ebrahimi Warkiani, Majid

“…We present here a new method to easily and reliably generate an array of hundreds of dispersed nanoliter-volume semi-droplets for single-cells culture and…”
Get more information

Driver assessment service for people with mental illness by Chiu, Calvin WC, Law, Colin KM, Cheng, Andy SK

“…Abstract Mental illness often leads to functional deficits that likely affect one’s driving performance and may even pose threat to other road users. However,…”
Get full text

MASTL overexpression promotes chromosome instability and metastasis in breast cancer by Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Gallego-Ortega, David, Law, Andrew M. K., Chin, Venessa T., Conway, James R. W., Fey, Dirk, Millar, Ewan K. A., O’Toole, Sandra, Deng, Niantao, Swarbrick, Alexander, Chastain, Paul D., Cesare, Anthony J., Timpson, Paul, Caldon, C. Elizabeth, Croucher, David R., James, David E., Watkins, D. Neil, Burgess, Andrew

“…MASTL kinase is essential for correct progression through mitosis, with loss of MASTL causing chromosome segregation errors, mitotic collapse and failure of…”
Get full text

A randomized controlled trial of social cognition and interaction training for persons with first episode psychosis in Hong Kong by Lo, Panmi M T, Lui, Simon S Y, Law, Colin K M, Roberts, David L, Siu, Andrew M H

“…Social cognitive impairment is a core limiting factor of functional recovery among persons with first episode psychosis (FEP). Social Cognition and Interaction…”
Get full text