Search Results - "Law, Julie A"

Establishing, maintaining and modifying DNA methylation patterns in plants and animals by Jacobsen, Steven E, Law, Julie A

“…Key Points Recent studies have shown that RNA-directed DNA methylation (RdDM) in Arabidopsis thaliana not only requires the production of 24-nucleotide small…”
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Locus-specific control of the de novo DNA methylation pathway in Arabidopsis by the CLASSY family by Zhou, Ming, Palanca, Ana Marie S., Law, Julie A.

“…DNA methylation is essential for gene regulation, transposon silencing and imprinting. Although the generation of specific DNA methylation patterns is critical…”
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The CLASSY family controls tissue-specific DNA methylation patterns in Arabidopsis by Zhou, Ming, Coruh, Ceyda, Xu, Guanghui, Martins, Laura M., Bourbousse, Clara, Lambolez, Alice, Law, Julie A.

“…DNA methylation shapes the epigenetic landscape of the genome, plays critical roles in regulating gene expression, and ensures transposon silencing. As is…”
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Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping by Gabrieli, Tslil, Michaeli, Yael, Avraham, Sigal, Torchinsky, Dmitry, Margalit, Sapir, Schütz, Leonie, Juhasz, Matyas, Coruh, Ceyda, Arbib, Nissim, Zhou, Zhaohui Sunny, Law, Julie A, Weinhold, Elmar, Ebenstein, Yuval

“…Abstract DNA methylation, specifically, methylation of cytosine (C) nucleotides at the 5-carbon position (5-mC), is the most studied and significant epigenetic…”
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Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1 by Law, Julie A., Du, Jiamu, Hale, Christopher J., Feng, Suhua, Krajewski, Krzysztof, Palanca, Ana Marie S., Strahl, Brian D., Patel, Dinshaw J., Jacobsen, Steven E.

“…In Arabidopsis , RNA-directed DNA methylation is a poorly understood gene silencing pathway in which small interfering RNAs generated by RNA polymerase IV…”
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SET DOMAIN GROUP2 is the major histone H3 lysine 4 trimethyltransferase in Arabidopsis by Guo, Lin, Yu, Yanchun, Law, Julie A., Zhang, Xiaoyu, Wessler, Susan

“…Posttranslational modifications of histones play important roles in modulating chromatin structure and regulating gene expression. We have previously shown…”
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DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons by Zhong, Xuehua, Hale, Christopher J, Law, Julie A, Johnson, Lianna M, Feng, Suhua, Tu, Andy, Jacobsen, Steven E

“…Plant RNA Pol V is involved in the RNA-directed DNA-methylation pathway that leads to heterochromatic silencing at some endogenous loci. Now the genomic…”
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AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications by Luebeck, Jens, Coruh, Ceyda, Dehkordi, Siavash R., Lange, Joshua T., Turner, Kristen M., Deshpande, Viraj, Pai, Dave A., Zhang, Chao, Rajkumar, Utkrisht, Law, Julie A., Mischel, Paul S., Bafna, Vineet

“…Oncogene amplification, a major driver of cancer pathogenicity, is often mediated through focal amplification of genomic segments. Recent results implicate…”
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SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV by Law, Julie A, Vashisht, Ajay A, Wohlschlegel, James A, Jacobsen, Steven E

“…DNA methylation is an evolutionarily conserved epigenetic modification that is critical for gene silencing and the maintenance of genome integrity. In…”
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A Protein Complex Required for Polymerase V Transcripts and RNA- Directed DNA Methylation in Arabidopsis by Law, Julie A., Ausin, Israel, Johnson, Lianna M., Vashisht, Ajay A., Zhu, Jian-Kang, Wohlschlegel, James A., Jacobsen, Steven E.

“…DNA methylation is an epigenetic modification associated with gene silencing. In Arabidopsis, DNA methylation is established by DOMAINS REARRANGED…”
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A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo by Rajakumara, Eerappa, Law, Julie A, Simanshu, Dhirendra K, Voigt, Philipp, Johnson, Lianna M, Reinberg, Danny, Patel, Dinshaw J, Jacobsen, Steven E

“…Cytosine DNA methylation is evolutionarily ancient, and in eukaryotes this epigenetic modification is associated with gene silencing. Proteins with SRA (SET-…”
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SRA-domain proteins required for DRM2-mediated de novo DNA methylation by Johnson, Lianna M, Law, Julie A, Khattar, Anuj, Henderson, Ian R, Jacobsen, Steven E

“…De novo DNA methylation and the maintenance of DNA methylation in asymmetrical sequence contexts is catalyzed by homologous proteins in plants (DRM2) and…”
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SOG1 activator and MYB3R repressors regulate a complex DNA damage network in Arabidopsis by Bourbousse, Clara, Vegesna, Neeraja, Law, Julie A.

“…To combat DNA damage, organisms mount a DNA damage response (DDR) that results in cell cycle regulation, DNA repair and, in severe cases, cell death…”
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Loops, crosstalk, and compartmentalization: it takes many layers to regulate DNA methylation by Xu, Guanghui, Law, Julie A

“…DNA methylation is a conserved epigenetic modification associated with transposon silencing and gene regulation. The stability of this modification relies on…”
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RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules by Zhou, Ming, Law, Julie A

“…•Plants encode extra RNA polymerases (Pol IV and V) that facilitate DNA methylation.•Pol IV and V subunits evolved from Pol II subunits, and are continuing to…”
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The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status by Li, Dongming, Palanca, Ana Marie S, Won, So Youn, Gao, Lei, Feng, Ying, Vashisht, Ajay A, Liu, Li, Zhao, Yuanyuan, Liu, Xigang, Wu, Xiuyun, Li, Shaofang, Le, Brandon, Kim, Yun Ju, Yang, Guodong, Li, Shengben, Liu, Jinyuan, Wohlschlegel, James A, Guo, Hongwei, Mo, Beixin, Chen, Xuemei, Law, Julie A

“…DNA methylation is associated with gene silencing in eukaryotic organisms. Although pathways controlling the establishment, maintenance and removal of DNA…”
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Moving targets: mechanisms regulating siRNA production and DNA methylation during plant development by Martins, Laura M., Law, Julie A.

“…DNA methylation is a conserved modification that must be precisely regulated during development to facilitate its roles in silencing transposable elements and…”
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Identification of genes required for de novo DNA methylation in Arabidopsis by Greenberg, Maxim V.C., Ausin, Israel, Chan, Simon W.L., Cokus, Shawn J., Cuperus, Josh T., Feng, Suhua, Law, Julie A., Chu, Carolyn, Pellegrini, Matteo, Carrington, James C., Jacobsen, Steven E.

“…De novo DNA methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3. DRM2 is…”
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Directions for research and training in plant omics: Big Questions and Big Data by Argueso, Cristiana T., Assmann, Sarah M., Birnbaum, Kenneth D., Chen, Sixue, Dinneny, José R., Doherty, Colleen J., Eveland, Andrea L., Friesner, Joanna, Greenlee, Vanessa R., Law, Julie A., Marshall‐Colón, Amy, Mason, Grace Alex, O'Lexy, Ruby, Peck, Scott C., Schmitz, Robert J., Song, Liang, Stern, David, Varagona, Marguerite J., Walley, Justin W., Williams, Cranos M.

“…A key remit of the NSF‐funded “Arabidopsis Research and Training for the 21st Century” (ART‐21) Research Coordination Network has been to convene a series of…”
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Circular ecDNA promotes accessible chromatin and high oncogene expression by Wu, Sihan, Turner, Kristen M., Nguyen, Nam, Raviram, Ramya, Erb, Marcella, Santini, Jennifer, Luebeck, Jens, Rajkumar, Utkrisht, Diao, Yarui, Li, Bin, Zhang, Wenjing, Jameson, Nathan, Corces, M. Ryan, Granja, Jeffrey M., Chen, Xingqi, Coruh, Ceyda, Abnousi, Armen, Houston, Jack, Ye, Zhen, Hu, Rong, Yu, Miao, Kim, Hoon, Law, Julie A., Verhaak, Roel G. W., Hu, Ming, Furnari, Frank B., Chang, Howard Y., Ren, Bing, Bafna, Vineet, Mischel, Paul S.

“…Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer 1 , 2 , but our understanding of the structure of ecDNA and its effect…”
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