Search Results - "Law, Christopher J."

Ins and Outs of Major Facilitator Superfamily Antiporters by LAW, Christopher J, MALONEY, Peter C, WANG, Da-Neng

“…The major facilitator superfamily (MFS) represents the largest group of secondary active membrane transporters, and its members transport a diverse range of…”
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Characterization of the substrate binding site of an iron detoxifying membrane transporter from Plasmodium falciparum by Sharma, Pragya, Tóth, Veronika, Hyland, Edel M, Law, Christopher J

“…Background Plasmodium species are entirely dependent upon their host as a source of essential iron. Although it is an indispensable micronutrient, oxidation of…”
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Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures by Karpowich, Nathan K, Wang, Da-Neng, Reith, Maarten E A, Zhen, Juan, Law, Christopher J, Zhou, Zheng

“…Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin-reuptake inhibitors (SSRIs) that are widely prescribed to treat depression. They bind to…”
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LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake by Zhou, Zheng, Zhen, Juan, Karpowich, Nathan K, Goetz, Regina M, Law, Christopher J, Reith, Maarten E.A, Wang, Da-Neng

“…Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking…”
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A Review of the Emerging White Chick Hatchery Disease by McIlwaine, Kerry, Law, Christopher J, Lemon, Ken, Grant, Irene R, Smyth, Victoria J

“…White chick hatchery disease is an emerging disease of broiler chicks with which the virus, chicken astrovirus, has been associated. Adult birds typically show…”
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A negative charge at position D +5 of Motif A is critical for function of the major facilitator superfamily multidrug/H + antiporter MdtM by Law, Christopher J.

“…The phenomenon of antimicrobial resistance represents a major public health risk. The activity of integral membrane transporter proteins contributes to…”
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Competition between protons and substrate for binding to the major facilitator superfamily multidrug/H + antiporter MdtM by Law, Christopher J.

“…Proton electrochemical gradient-driven multidrug efflux activity of representatives of the major facilitator superfamily (MFS) of secondary active transporters…”
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Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli by Holdsworth, Scarlett R, Law, Christopher J

“…In neutralophilic bacteria, monovalent metal cation/H+ antiporters play a key role in pH homeostasis. In Escherichia coli, only four antiporters (NhaA, NhaB,…”
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Erratum to: Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli by Holdsworth, Scarlett R, Law, Christopher J

“…It has been brought to our attention after publication that there is an error in Fig. 2 of our article [1]. The panel in Fig. 2a which purported to show the…”
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Salt-bridge Dynamics Control Substrate-induced Conformational Change in the Membrane Transporter GlpT by Law, Christopher J., Almqvist, Jonas, Bernstein, Adam, Goetz, Regina M., Huang, Yafei, Soudant, Celine, Laaksonen, Aatto, Hovmöller, Sven, Wang, Da-Neng

“…Active transport of substrates across cytoplasmic membranes is of great physiological, medical and pharmaceutical importance. The glycerol-3-phosphate (G3P)…”
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Purification of a Multidrug Resistance Transporter for Crystallization Studies by Alegre, Kamela O, Law, Christopher J

“…Crystallization of integral membrane proteins is a challenging field and much effort has been invested in optimizing the overexpression and purification steps…”
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Clamping down on drugs: the Escherichia coli multidrug efflux protein MdtM by Law, Christopher J., Alegre, Kamela O.

“…Multidrug resistance is principally a consequence of the active transport of drugs out of the cell by proteins that are integral membrane transporters. In the…”
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Insight into determinants of substrate binding and transport in a multidrug efflux protein by Alegre, Kamela O., Paul, Stephanie, Labarbuta, Paola, Law, Christopher J.

“…Multidrug resistance arising from the activity of integral membrane transporter proteins presents a global public health threat. In bacteria such as…”
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The structure and function of bacterial light-harvesting complexes by Law, Christopher J, Roszak, Aleksander W, Southall, June, Gardiner, Alastair T, Isaacs, Neil W, Cogdell, Richard J

“…The harvesting of solar radiation by purple photosynthetic bacteria is achieved by circular, integral membrane pigment-protein complexes. There are two main…”
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Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a Fe2+/H+exchanger by Labarbuta, Paola, Duckett, Katie, Botting, Catherine H., Chahrour, Osama, Malone, John, Dalton, John P., Law, Christopher J.

“…Vacuolar iron transporters (VITs) are a poorly understood family of integral membrane proteins that can function in iron homeostasis via sequestration of…”
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Functional and biochemical characterisation of the Escherichia coli major facilitator superfamily multidrug transporter MdtM by Holdsworth, Scarlett R., Law, Christopher J.

“…Multidrug resistance (MDR) occurs when bacteria simultaneously acquire resistance to a broad spectrum of structurally dissimilar compounds to which they have…”
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A single‐component multidrug transporter of the major facilitator superfamily is part of a network that protects Escherichia coli from bile salt stress by Paul, Stephanie, Alegre, Kamela O., Holdsworth, Scarlett R., Rice, Matthew, Brown, James A., McVeigh, Paul, Kelly, Sharon M., Law, Christopher J.

“…Summary Resistance to high concentrations of bile salts in the human intestinal tract is vital for the survival of enteric bacteria such as Escherichia coli…”
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Interactions Stabilizing the Structure of the Core Light-Harvesting Complex (LH1) of Photosynthetic Bacteria and Its Subunit (B820) by Parkes-Loach, Pamela S., Majeed, Alia P., Law, Christopher J., Loach, Paul A.

“…Reconstitution experiments with a chemically synthesized core light-harvesting (LH1) β-polypeptide analogue having 3-methylhistidine instead of histidine in…”
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Structural Basis of Substrate Selectivity in the Glycerol-3-Phosphate: Phosphate Antiporter GlpT by Law, Christopher J., Enkavi, Giray, Wang, Da-Neng, Tajkhorshid, Emad

“…Major facilitators represent the largest superfamily of secondary active transporter proteins and catalyze the transport of an enormous variety of small solute…”
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The major facilitator superfamily transporter MdtM contributes to the intrinsic resistance of Escherichia coli to quaternary ammonium compounds by Holdsworth, Scarlett R, Law, Christopher J

“…Quaternary ammonium compounds (QACs) are used extensively as biocides and their misuse may be contributing to the development of bacterial resistance. Although…”
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