Search Results - "Law, Brian C."

Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase by Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason

“…Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic…”
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An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins by Struck, Anna-Winona, Bennett, Matthew R, Shepherd, Sarah A, Law, Brian J. C, Zhuo, Ying, Wong, Lu Shin, Micklefield, Jason

“…Bioorthogonal chemistry enables a specific moiety in a complex biomolecule to be selectively modified in the presence of many reactive functional groups and…”
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A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups by Jiang, Yuanbing, Uhm, Hyebin, Ip, Fanny C., Ouyang, Li, Lo, Ronnie M. N., Cheng, Elaine Y. L., Cao, Xiaoyun, Tan, Clara M. C., Law, Brian C. H., Ortiz‐Romero, Paula, Puig‐Pijoan, Albert, Fernández‐Lebrero, Aida, Contador, José, Mok, Kin Y., Hardy, John, Kwok, Timothy C. Y., Mok, Vincent C. T., Suárez‐Calvet, Marc, Zetterberg, Henrik, Fu, Amy K. Y., Ip, Nancy Y.

“…INTRODUCTION Existing blood‐based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood‐based biomarkers…”
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Site-specific bioalkylation of rapamycin by the RapM 16- O -methyltransferase by Law, Brian J C, Struck, Anna-Winona, Bennett, Matthew R, Wilkinson, Barrie, Micklefield, Jason

“…The methylation of natural products by -adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in many…”
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Factors used in Applicant Ranking of Orthopedic Foot and Ankle Fellowships and the Availability of Online Information by Kraus, Jonathan C., Perlewitz, Madeline A., Shi, Glenn G., Law, Brian C.

“…Background: The Internet is often the first resource used by applicants to evaluate fellowship programs. However, information on these websites can be often…”
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Gene editing enables rapid engineering of complex antibiotic assembly lines by Thong, Wei Li, Zhang, Yingxin, Zhuo, Ying, Robins, Katherine J., Fyans, Joanna K., Herbert, Abigail J., Law, Brian J. C., Micklefield, Jason

“…Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases (NRPS) and related megasynthase enzymes, is a powerful route to new…”
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Multi-Segment Foot and Ankle Gait Kinematics Following Total Ankle Arthroplasty by Wiese, Dylan, Fritz, Jessica M., Canseco, Karl, Meinerz, Carolyn M., Konop, Katherine, Law, Brian C.

“…Category: Ankle Arthritis; Ankle. Introduction/Purpose: Ankle arthritis is a painful disease resulting in limited function, mobility, and quality of life.1…”
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Patient Knowledge of Provider Training Background and Preferences for Treatment of Foot and Ankle Conditions by Nielsen, Alex W., Law, Brian C., Shi, Glenn G., Kraus, Jonathan C.

“…Category: Professional, Patient Care Introduction/Purpose: Differences exist in the training backgrounds of medical providers who treat foot and ankle…”
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A Flavin-Dependent Decarboxylase–Dehydrogenase–Monooxygenase Assembles the Warhead of α,β-Epoxyketone Proteasome Inhibitors by Zabala, Daniel, Cartwright, Joshua W, Roberts, Douglas M, Law, Brian J. C, Song, Lijiang, Samborskyy, Markiyan, Leadlay, Peter F, Micklefield, Jason, Challis, Gregory L

“…The α,β-epoxyketone proteasome inhibitor TMC-86A was discovered as a previously unreported metabolite of Streptomyces chromofuscus ATCC49982, and the gene…”
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Multi‐segment foot kinematics during gait following ankle arthroplasty by Fritz, Jessica M., Canseco, Karl, Konop, Katherine A., Kruger, Karen M., Tarima, Sergey, Long, Jason T., Law, Brian C., Kraus, Jonathan C., King, David M., Harris, Gerald F.

“…Ankle arthritis is a debilitating disease marked by pain and limited function. Total ankle arthroplasty improves pain while preserving motion and offers an…”
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Peak Contact Stress of TMT-1 Joint after Sequential Correction of Hallux Valgus Using a Proximal Opening Wedge Metatarsal Osteotomy (PMO) and Distal Soft Tissue Procedure by Kraus, Jonathan C., Ziegele, Michael, Law, Mei Wang; Brian C., Shi, Glenn G.

“…Category: Bunion; Midfoot/Forefoot Introduction/Purpose: The proximal opening wedge metatarsal osteotomy (PMO) of the first metatarsal is a common procedure…”
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A Retrospective Study Characterizing the Radiographic Progression of Hallux Valgus by Kukushliev, Vasil V, Burton, Alex T, Shi, Glenn G, Law, Brian C, Kraus, Jonathan C

“…Hallux valgus deformity is the lateral deviation of the metatarsophalangeal (MTP) joint and is the most common pathology of the great toe, affecting 2%-4% of…”
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Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase by Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason

“…Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic…”
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Engineered biosynthesis of enduracidin lipoglycopeptide antibiotics using the ramoplanin mannosyltransferase Ram29 by Wu, Ming-Cheng, Styles, Matthew Q, Law, Brian J C, Struck, Anna-Winona, Nunns, Laura, Micklefield, Jason

“…The lipopeptides ramoplanin from Actinoplanes sp. ATCC 33076 and enduracidin produced by Streptomyces fungicidicus are effective antibiotics against a number…”
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Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferaseElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00164a by Law, Brian J. C, Struck, Anna-Winona, Bennett, Matthew R, Wilkinson, Barrie, Micklefield, Jason

“…The methylation of natural products by S -adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in…”
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Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc00164a by Law, Brian J. C., Struck, Anna-Winona, Bennett, Matthew R., Wilkinson, Barrie, Micklefield, Jason

“…Characterisation of a rapamycin O -methyltransferase (RapM) and its utilisation in coupled reactions, with an improved variant of the human methionine adenosyl…”
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A vitamin K-dependent carboxylase orthologue is involved in antibiotic biosynthesis by Law, Brian J. C., Zhuo, Ying, Winn, Michael, Francis, Daniel, Zhang, Yingxin, Samborskyy, Markiyan, Murphy, Annabel, Ren, Lujing, Leadlay, Peter F., Micklefield, Jason

“…Vitamin K-dependent carboxylase (VKDC) enzymes modify glutamate residues in mammalian vitamin K-dependent proteins, generating γ-carboxyglutamic acids with…”
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