Search Results - "Lavrnja, Irena"
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Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis
Published in Journal of neuroscience research (01-06-2018)“…Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system (CNS) that affects more than two million people worldwide. Several…”
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Thiamine and benfotiamine: Focus on their therapeutic potential
Published in Heliyon (01-11-2023)“…Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in energy metabolism and overall health. It is a water-soluble vitamin…”
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Experimental Autoimmune Encephalomyelitis Influences GH-Axis in Female Rats
Published in International journal of molecular sciences (01-06-2024)“…Inflammation, demyelination, and axonal damage to the central nervous system (CNS) are the hallmarks of multiple sclerosis (MS) and its representative animal…”
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Hyperbaric Oxygenation Prevents Loss of Immature Neurons in the Adult Hippocampal Dentate Gyrus Following Brain Injury
Published in International journal of molecular sciences (21-02-2023)“…A growing body of evidence suggests that hyperbaric oxygenation (HBO) may affect the activity of adult neural stem cells (NSCs). Since the role of NSCs in…”
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Benfotiamine attenuates inflammatory response in LPS stimulated BV-2 microglia
Published in PloS one (19-02-2015)“…Microglial cells are resident immune cells of the central nervous system (CNS), recognized as key elements in the regulation of neural homeostasis and the…”
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Testicular steroidogenesis is suppressed during experimental autoimmune encephalomyelitis in rats
Published in Scientific reports (26-04-2021)“…Multiple sclerosis (MS) is an autoimmune disease that usually occurs during the reproductive years in both sexes. Many male patients with MS show lower blood…”
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NRF2 Plays a Crucial Role in the Tolerogenic Effect of Ethyl Pyruvate on Dendritic Cells
Published in International journal of molecular sciences (01-06-2024)“…Ethyl pyruvate (EP) is a redox-active compound that has been previously shown to be effective in restraining immune hyperactivity in animal models of various…”
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Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord
Published in Scientific reports (02-06-2017)“…Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an…”
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Agmatine Mitigates Inflammation-Related Oxidative Stress in BV-2 Cells by Inducing a Pre-Adaptive Response
Published in International journal of molecular sciences (24-03-2022)“…Neuroinflammation and microglial activation, common components of most neurodegenerative diseases, can be imitated in vitro by challenging microglia cells with…”
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Antenatal Dexamethasone Treatment Induces Sex-dependent Upregulation of NTPDase1/CD39 and Ecto-5ʹ-nucleotidase/CD73 in the Rat Fetal Brain
Published in Cellular and molecular neurobiology (01-08-2022)“…Dexamethasone (DEX) is frequently used to treat women at risk of preterm delivery, but although indispensable for the completion of organ maturation in the…”
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Benfotiamine Reduces Dendritic Cell Inflammatory Potency
Published in Endocrine, metabolic & immune disorders drug targets (01-01-2021)“…Benfotiamine is a synthetic liposoluble derivative of vitamin B1 that has been shown to have anti-inflammatory properties. To study the effects of benfotiamine…”
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The Function of the Hypothalamic–Pituitary–Adrenal Axis During Experimental Autoimmune Encephalomyelitis: Involvement of Oxidative Stress Mediators
Published in Frontiers in neuroscience (17-06-2021)“…Multiple sclerosis (MS) is an inflammatory, demyelinating disease with an unknown origin. Previous studies showed the involvement of the…”
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Alterations in the Hypothalamic-Pituitary-Adrenal Axis as a Response to Experimental Autoimmune Encephalomyelitis in Dark Agouti Rats of Both Sexes
Published in Biomolecules (Basel, Switzerland) (01-08-2024)“…Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, usually diagnosed during the reproductive period. Both MS…”
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Effects of agmatine on chlorpromazine toxicity in the liver of Wistar rats: the possible role of oxidant/antioxidant imbalance
Published in Experimental Animals (01-01-2017)“…Chlorpromazine (CPZ) is a member of a widely used class of antipsychotic agents. The metabolic pathways of CPZ toxicity were examined by monitoring…”
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Induction of NTPDase1/CD39 by Reactive Microglia and Macrophages Is Associated With the Functional State During EAE
Published in Frontiers in neuroscience (26-04-2019)“…Purinergic signaling is critically involved in neuroinflammation associated with multiple sclerosis (MS) and its major inflammatory animal model, experimental…”
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Theta burst stimulation influence the expression of BDNF in the spinal cord on the experimental autoimmune encephalomyelitis
Published in Folia neuropathologica (01-01-2019)“…Repetitive transcranial magnetic stimulation (rTMS) induces changes in expression of proteins engaged in the activity of excitatory and inhibitory systems,…”
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Down-regulation of NTPDase2 and ADP-sensitive P2 Purinoceptors Correlate with Severity of Symptoms during Experimental Autoimmune Encephalomyelitis
Published in Frontiers in cellular neuroscience (30-10-2017)“…The present study explores tissue and cellular distribution of ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) and the gene and protein expression…”
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Rat Ovarian Function Is Impaired during Experimental Autoimmune Encephalomyelitis
Published in Cells (Basel, Switzerland) (30-03-2023)“…Multiple sclerosis (MS) is an autoimmune disease affecting the CNS and occurring far more prevalently in women than in men. In both MS and its animal models,…”
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Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro
Published in ASN neuro (2022)“…Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y1,12,13 receptors. The present…”
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The Effect of Ribavirin on Reactive Astrogliosis in Experimental Autoimmune Encephalomyelitis
Published in Journal of Pharmacological Sciences (2012)“…Experimental autoimmune encephalomyelitis (EAE) is an animal model of CNS inflammatory and demyelinating disease multiple sclerosis. Microglia and astrocytes…”
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