Search Results - "Lavrik, O. I."

Dna is a New Target of Parp3 by Belousova, E. A., Ishchenko, А. A., Lavrik, O. I.

“…Most members of the poly(ADP-ribose)polymerase family, PARP family, have a catalytic activity that involves the transfer of ADP-ribose from a…”
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The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context by Kutuzov, M. M., Belousova, E. A., Kurgina, T. A., Ukraintsev, A. A., Vasil’eva, I. A., Khodyreva, S. N., Lavrik, O. I.

“…The regulation of repair processes including base excision repair (BER) in the presence of DNA damage is implemented by a cellular signal:…”
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The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo by Nikolin, V. P., Popova, N. A., Kaledin, V. I., Luzina, O. A., Zakharenko, A. L., Salakhutdinov, N. F., Lavrik, O. I.

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a repair enzyme for 3′-end DNA lesions, predominantly stalled DNA–topoisomerase 1 (Top1) cleavage complexes. Tdp1 is…”
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Non-Catalytic Domains of DNA Polymerase λ: Influence on Enzyme Activity and Its Regulation by Maltseva, E. A., Rechkunova, N. I., Lavrik, O. I.

“…DNA polymerase λ (Polλ) belongs to the same structural X-family as DNA polymerase β, the main polymerase of base excision repair. The role of Polλ in this…”
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Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1) by Khodyreva, S. N., Prasad, R., Ilina, E. S., Sukhanova, M. V., Kutuzov, M. M., Liu, Y., Hou, E. W., Wilson, S. H., Lavrik, O. I., Hanawalt, Philip C.

“…The capacity of human poly(ADP-ribose) polymerase-1 (PARP-1) to interact with intact apurinic/apyrimidinic (AP) sites in DNA has been demonstrated. In cell…”
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Characterization of the Altai Maral Chymosin Gene, Production of a Chymosin Recombinant Analog in the Prokaryotic Expression System, and Analysis of Its Several Biochemical Properties by Belenkaya, S. V., Bondar, A. A., Kurgina, T. A., Elchaninov, V. V., Bakulina, A. Yu, Rukhlova, E. A., Lavrik, O. I., Ilyichev, A. A., Shcherbakov, D. N.

“…For the first time, the chymosin gene ( CYM ) of a maral was characterized. Its exon/intron organization was established using comparative analysis of the…”
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PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes by Zakharenko, A. L., Malakhova, A. A., Dyrkheeva, N. S., Okorokova, L. S., Medvedev, S. P., Zakian, S. M., Kabilov, M. R., Tupikin, A. A., Lavrik, O. I.

“…The effect of PARP1 knockout in HEK293 cells on the gene expression of DNA base excision repair (BER) proteins was studied. It was shown that the expression of…”
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Influence of Tyrosyl-DNA Phosphodiesterase 1 Inhibitor on the Proapoptotic and Genotoxic Effects of Anticancer Agent Topotecan by Chepanova, A. A., Zakharenko, A. L., Dyrkheeva, N. S., Chernyshova, I. A., Zakharova, O. D., Ilina, E. S., Luzina, O. A., Salakhutdinov, N. F., Lavrik, O. I.

“…To date, various strategies have been proposed to increase the efficiency of cancer therapy. It is known that the action of DNA repair system can determine the…”
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DNA polymerases β and λ and their roles in cell by Belousova, E.A., Lavrik, O.I.

“…•Biochemical properties.•Involvement in base excision repair, translesion synthesis and repair of clustered damages.•Role in aging and cancer. Among the set of…”
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AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites by Dyrkheeva, N. S., Lebedeva, N. A., Lavrik, O. I.

“…Human apurinic/apyrimidinic endonuclease 1 (APE1) is one of the key participants in the DNA base excision repair system. APE1 hydrolyzes DNA adjacent to the…”
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Poly(ADP-Ribose) polymerase 1 as a key regulator of DNA repair by Khodyreva, S. N., Lavrik, O. I.

“…Poly(ADP-ribosyl)ation (PARylation) of proteins is one of the immediate cell responses to DNA damage and is catalyzed by poly(ADP-ribose) polymerases (PARPs)…”
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Role of Oxidation of XRCC1 Protein in Regulation of Mammalian DNA Repair Process by Vasil’eva, I. A., Moor, N. A., Lavrik, O. I.

“…The influence of XRCC1 protein oxidation on the modification of proteins catalyzed by poly(ADP-ribose)polymerases (PARP1 and PARP2) was studied for the first…”
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Repair of clustered damage and DNA polymerase iota by Belousova, E. A., Lavrik, O. I.

“…Multiple DNA lesions occurring within one or two turns of the DNA helix known as clustered damage are a source of double-stranded DNA breaks, which represent a…”
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Mechanisms of single-stranded DNA-binding protein functioning in cellular DNA metabolism by Pestryakov, P. E, Lavrik, O. I

“…This review deals with analysis of mechanisms involved in coordination of DNA replication and repair by SSB proteins; characteristics of eukaryotic,…”
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Protein–Protein Interactions in DNA Base Excision Repair by Moor, N. A., Lavrik, O. I.

“…The system of base excision repair (BER) ensures correction of the most abundant DNA damages in mammalian cells and plays an important role in maintaining…”
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Interaction of nucleotide excision repair protein XPC—RAD23B with DNA containing benzo[a]pyrene-derived adduct and apurinic/apyrimidinic site within a cluster by Starostenko, L. V., Maltseva, E. A., Lebedeva, N. A., Pestryakov, P. E., Lavrik, O. I., Rechkunova, N. I.

“…The combined action of reactive metabolites of benzo[a]pyrene (B[a]P) and oxidative stress can lead to cluster-type DNA damage that includes both a bulky…”
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DNA with damage in both strands as affinity probes and nucleotide excision repair substrates by Lukyanchikova, N. V., Petruseva, I. O., Evdokimov, A. N., Silnikov, V. N., Lavrik, O. I.

“…Nucleotide excision repair (NER) is a multistep process of recognition and elimination of a wide spectrum of damages that cause significant distortions in DNA…”
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Role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in DNA repair by Kosova, A. A., Khodyreva, S. N., Lavrik, O. I.

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is widely known as a glycolytic enzyme. Nevertheless, various functions of GAPDH have been found that are…”
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Y-box binding protein 1 (YB-1) promotes detection of DNA bulky lesions by XPC-HR23B factor by Fomina, E. E., Pestryakov, P. E., Maltseva, E. A., Petruseva, I. O., Kretov, D. A., Ovchinnikov, L. P., Lavrik, O. I.

“…The nucleotide excision repair system (NER) is one of the main mechanisms protecting cellular DNA from lesions caused by such significant environmental factors…”
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Photoactivated DNA analogs of substrates of the nucleotide excision repair system and their interaction with proteins of NER-competent extract of HeLa cells. Synthesis and application of long model DNA by Evdokimov, A. N, Petruseva, I. O, Pestryakov, P. E, Lavrik, O. I

“…Long linear DNA analogs of nucleotide excision repair (NER) substrates have been synthesized. They are 137-mer duplexes containing in their internal positions…”
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