Search Results - "Lavine, Christy L."

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant by Zhang, Jun, Xiao, Tianshu, Cai, Yongfei, Lavine, Christy L, Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Mayer, Megan L, Walsh, Jr, Richard M, Rits-Volloch, Sophia, Wesemann, Duane R, Yang, Wei, Seaman, Michael S, Lu, Jianming, Chen, Bing

“…The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain…”
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Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants by Cai, Yongfei, Zhang, Jun, Xiao, Tianshu, Lavine, Christy L, Rawson, Shaun, Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Lu, Shen, Sterling, Sarah M, Walsh, Jr, Richard M, Rits-Volloch, Sophia, Lu, Jianming, Wesemann, Duane R, Yang, Wei, Seaman, Michael S, Chen, Bing

“…Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains in the COVID-19…”
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A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent by Xiao, Tianshu, Lu, Jianming, Zhang, Jun, Johnson, Rebecca I., McKay, Lindsay G. A., Storm, Nadia, Lavine, Christy L., Peng, Hanqin, Cai, Yongfei, Rits-Volloch, Sophia, Lu, Shen, Quinlan, Brian D., Farzan, Michael, Seaman, Michael S., Griffiths, Anthony, Chen, Bing

“…Effective intervention strategies are urgently needed to control the COVID-19 pandemic. Human angiotensin-converting enzyme 2 (ACE2) is a membrane-bound…”
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Structural and functional impact by SARS-CoV-2 Omicron spike mutations by Zhang, Jun, Cai, Yongfei, Lavine, Christy L., Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Tong, Pei, Gautam, Avneesh, Mayer, Megan L., Rits-Volloch, Sophia, Wang, Shaowei, Sliz, Piotr, Wesemann, Duane R., Yang, Wei, Seaman, Michael S., Lu, Jianming, Xiao, Tianshu, Chen, Bing

“…The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bearing an unusually high number of mutations, has become a dominant…”
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Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike by Tong, Pei, Gautam, Avneesh, Windsor, Ian W., Travers, Meghan, Chen, Yuezhou, Garcia, Nicholas, Whiteman, Noah B., McKay, Lindsay G.A., Storm, Nadia, Malsick, Lauren E., Honko, Anna N., Lelis, Felipe J.N., Habibi, Shaghayegh, Jenni, Simon, Cai, Yongfei, Rennick, Linda J., Duprex, W. Paul, McCarthy, Kevin R., Lavine, Christy L., Zuo, Teng, Lin, Junrui, Zuiani, Adam, Feldman, Jared, MacDonald, Elizabeth A., Hauser, Blake M., Griffths, Anthony, Seaman, Michael S., Schmidt, Aaron G., Chen, Bing, Neuberg, Donna, Bajic, Goran, Harrison, Stephen C., Wesemann, Duane R.

“…Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2 infections, but with unknown reach from original infection to…”
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A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption by Andrade, Viviane M., Mavian, Carla, Babic, Dunja, Cordeiro, Thaissa, Sharkey, Mark, Barrios, Labelle, Brander, Christian, Martinez-Picado, Javier, Dalmau, Judith, Llano, Anuska, Li, Jonathan Z., Jacobson, Jeffrey, Lavine, Christy L., Seaman, Michael S., Salemi, Marco, Stevenson, Mario

“…HIV-1 persists in cellular reservoirs that can reignite viremia if antiretroviral therapy (ART) is interrupted. Therefore, insight into the nature of those…”
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High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection by LAVINE, Christy L, LAO, Socheata, MONTEFIORI, David C, HAYNES, Barton F, SODROSKI, Joseph G, XINZHEN YANG

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences by Tartaglia, Lawrence J, Chang, Hui-Wen, Lee, Benjamin C, Abbink, Peter, Ng'ang'a, David, Boyd, Michael, Lavine, Christy L, Lim, So-Yon, Sanisetty, Srisowmya, Whitney, James B, Seaman, Michael S, Rolland, Morgane, Tovanabutra, Sodsai, Ananworanich, Jintanat, Robb, Merlin L, Kim, Jerome H, Michael, Nelson L, Barouch, Dan H

“…Simian-human immunodeficiency virus (SHIV) challenge stocks are critical for preclinical testing of vaccines, antibodies, and other interventions aimed to…”
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Identification of Francisella tularensis Lipoproteins That Stimulate the Toll-like Receptor (TLR) 2/TLR1 Heterodimer by Thakran, Shalini, Li, Hanfen, Lavine, Christy L., Miller, Mark A., Bina, James E., Bina, Xiaowen R., Re, Fabio

“…The innate immune response to Francisella tularensis is primarily mediated by TLR2, though the bacterial products that stimulate this receptor remain unknown…”
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Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant by Seaman, Michael S., Siedner, Mark J., Boucau, Julie, Lavine, Christy L., Ghantous, Fadi, Liew, May Y., Mathews, Josh I., Singh, Arshdeep, Marino, Caitlin, Regan, James, Uddin, Rockib, Choudhary, Manish C., Flynn, James P., Chen, Geoffrey, Stuckwisch, Ashley M., Lipiner, Taryn, Kittilson, Autumn, Melberg, Meghan, Gilbert, Rebecca F., Reynolds, Zahra, Iyer, Surabhi L., Chamberlin, Grace C., Vyas, Tammy D., Vyas, Jatin M., Goldberg, Marcia B., Luban, Jeremy, Li, Jonathan Z., Barczak, Amy K., Lemieux, Jacob E.

“…Protective immunity against SARS-CoV-2 infection after COVID-19 vaccination may differ by variant. We enrolled vaccinated (n = 39) and unvaccinated (n = 11)…”
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Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production by Chen, Yuezhou, Zuiani, Adam, Fischinger, Stephanie, Mullur, Jyotsna, Atyeo, Caroline, Travers, Meghan, Lelis, Felipe J.N., Pullen, Krista M., Martin, Hannah, Tong, Pei, Gautam, Avneesh, Habibi, Shaghayegh, Bensko, Jillian, Gakpo, Deborah, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Cai, Yongfei, Burke, John S., Lin, Junrui, Lederer, James A., Lam, Evan Christopher, Lavine, Christy L., Seaman, Michael S., Chen, Bing, Schmidt, Aaron G., Balazs, Alejandro Benjamin, Lauffenburger, Douglas A., Alter, Galit, Wesemann, Duane R.

“…Antibodies are key immune effectors that confer protection against pathogenic threats. The nature and longevity of the antibody response to SARS-CoV-2…”
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Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA by Lorenzi, Julio C. C., Cohen, Yehuda Z., Cohn, Lillian B., Kreider, Edward F., Barton, John P., Learn, Gerald H., Oliveira, Thiago, Lavine, Christy L., Horwitz, Joshua A., Settler, Allison, Jankovic, Mila, Seaman, Michael S., Chakraborty, Arup K., Hahn, Beatrice H., Caskey, Marina, Nussenzweig, Michel C.

“…HIV-1–infected individuals harbor a latent reservoir of infected CD4⁺ T cells that is not eradicated by antiretroviral therapy (ART). This reservoir presents…”
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HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes by Xiao, Tianshu, Frey, Gary, Fu, Qingshan, Lavine, Christy L., Scott, David A., Seaman, Michael S., Chou, James J., Chen, Bing

“…Combination antiretroviral therapy has transformed HIV-1 infection, once a fatal illness, into a manageable chronic condition. Drug resistance, severe side…”
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HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design by Bricault, Christine A., Yusim, Karina, Seaman, Michael S., Yoon, Hyejin, Theiler, James, Giorgi, Elena E., Wagh, Kshitij, Theiler, Maxwell, Hraber, Peter, Macke, Jennifer P., Kreider, Edward F., Learn, Gerald H., Hahn, Beatrice H., Scheid, Johannes F., Kovacs, James M., Shields, Jennifer L., Lavine, Christy L., Ghantous, Fadi, Rist, Michael, Bayne, Madeleine G., Neubauer, George H., McMahan, Katherine, Peng, Hanqin, Chéneau, Coraline, Jones, Jennifer J., Zeng, Jie, Ochsenbauer, Christina, Nkolola, Joseph P., Stephenson, Kathryn E., Chen, Bing, Gnanakaran, S., Bonsignori, Mattia, Williams, LaTonya D., Haynes, Barton F., Doria-Rose, Nicole, Mascola, John R., Montefiori, David C., Barouch, Dan H., Korber, Bette

“…Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs…”
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Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys by Barouch, Dan H., Alter, Galit, Broge, Thomas, Linde, Caitlyn, Ackerman, Margaret E., Brown, Eric P., Borducchi, Erica N., Smith, Kaitlin M., Nkolola, Joseph P., Liu, Jinyan, Shields, Jennifer, Parenteau, Lily, Whitney, James B., Abbink, Peter, Ng'ang'a, David M., Seaman, Michael S., Lavine, Christy L., Perry, James R., Li, Wenjun, Colantonio, Arnaud D., Lewis, Mark G., Chen, Bing, Wenschuh, Holger, Reimer, Ulf, Piatak, Michael, Lifson, Jeffrey D., Handley, Scott A., Virgin, Herbert W., Koutsoukos, Marguerite, Lorin, Clarisse, Voss, Gerald, Weijtens, Mo, Pau, Maria G., Schuitemaker, Hanneke

“…Preclinical studies of viral vector–based HIV-1 vaccine candidates have previously shown partial protection against neutralization-resistant virus challenges…”
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Structural and functional characteristics of the SARS-CoV-2 Omicron subvariant BA.2 spike protein by Zhang, Jun, Tang, Weichun, Gao, Hailong, Lavine, Christy L., Shi, Wei, Peng, Hanqin, Zhu, Haisun, Anand, Krishna, Kosikova, Matina, Kwon, Hyung Joon, Tong, Pei, Gautam, Avneesh, Rits-Volloch, Sophia, Wang, Shaowei, Mayer, Megan L., Wesemann, Duane R., Seaman, Michael S., Lu, Jianming, Xiao, Tianshu, Xie, Hang, Chen, Bing

“…The Omicron subvariant BA.2 has become the dominant circulating strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in many countries. Here,…”
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Immunization with heat-killed Francisella tularensis LVS elicits protective antibody-mediated immunity by Lavine, Christy L, Clinton, Shawn R, Angelova-Fischer, Irena, Marion, Tony N, Bina, Xiaowen R, Bina, James E, Whitt, Michael A, Miller, Mark A

“…Francisella tularensis (FT) has been classified by the CDC as a category A pathogen because of its high virulence and the high mortality rate associated with…”
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Autologous neutralizing antibodies increase with early antiretroviral therapy and shape HIV rebound after treatment interruption by Esmaeilzadeh, Elmira, Etemad, Behzad, Lavine, Christy L, Garneau, Lauren, Li, Yijia, Regan, James, Wong, Colline, Sharaf, Radwa, Connick, Elizabeth, Volberding, Paul, Sagar, Manish, Seaman, Michael S, Li, Jonathan Z

“…Early initiation of antiretroviral therapy (ART) alters viral rebound kinetics after analytic treatment interruption (ATI) and may play a role in promoting…”
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Antibody‐mediated SARS‐CoV‐2 entry in cultured cells by Kibria, Md Golam, Lavine, Christy L, Tang, Weichun, Wang, Shaowei, Gao, Hailong, Shi, Wei, Zhu, Haisun, Voyer, Jewel, Rits‐Volloch, Sophia, Keerti, Bi, Caihong, Peng, Hanqin, Wesemann, Duane R, Lu, Jianming, Xie, Hang, Seaman, Michael S, Chen, Bing

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) enters host cells by first engaging its cellular receptor angiotensin converting enzyme 2 (ACE2)…”
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Subtle Longitudinal Alterations in Env Sequence Potentiate Differences in Sensitivity to Broadly Neutralizing Antibodies following Acute HIV-1 Subtype C Infection by Mandizvo, Tawanda, Gumede, Nombali, Ndlovu, Bongiwe, Ndlovu, Siphiwe, Mann, Jaclyn K, Chopera, Denis R, Singh, Lanish, Dong, Krista L, Walker, Bruce D, Ndhlovu, Zaza M, Lavine, Christy L, Seaman, Michael S, Gounder, Kamini, Ndung'u, Thumbi

“…Broadly neutralizing antibodies (bNAbs) for HIV-1 prevention or cure strategies must inhibit transmitted/founder and reservoir viruses. Establishing…”
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