Search Results - "Lavi, S"

Negatively Charged Disordered Regions are Prevalent and Functionally Important Across Proteomes by Bigman, Lavi S., Iwahara, Junji, Levy, Yaakov

“…[Display omitted] •Intrinsically disordered regions in proteins are often highly charged and have polyampholytic characteristics.•In many other cases, the…”
Get full text

Proteins: molecules defined by their trade-offs by Bigman, Lavi S, Levy, Yaakov

“…Proteins are subject to various conflicting forces that trade-off against each other. For example, during folding, the protein achieves lower enthalpy at the…”
Get full text

ssDNA diffuses along replication protein A via a reptation mechanism by Mishra, Garima, Bigman, Lavi S, Levy, Yaakov

“…Replication protein A (RPA) plays a critical role in all eukaryotic DNA processing involving single-stranded DNA (ssDNA). Contrary to the notion that RPA…”
Get full text

Tubulin tails and their modifications regulate protein diffusion on microtubules by Bigman, Lavi S., Levy, Yaakov

“…Microtubules (MTs) are essential components of the eukaryotic cytoskeleton that serve as “highways” for intracellular trafficking. In addition to the…”
Get full text

Protein Diffusion Along Protein and DNA Lattices: Role of Electrostatics and Disordered Regions by Bigman, Lavi S, Levy, Yaakov

“…Diffusion is a pervasive process present in a broad spectrum of cellular reactions. Its mathematical description has existed for nearly two centuries and…”
Get full text

Protein Diffusion on Charged Biopolymers: DNA versus Microtubule by Bigman, Lavi S., Levy, Yaakov

“…Protein diffusion in lower-dimensional spaces is used for various cellular functions. For example, sliding on DNA is essential for proteins searching for their…”
Get full text

Modulating Microtubules: A Molecular Perspective on the Effects of Tail Modifications by Bigman, Lavi S., Levy, Yaakov

“…[Display omitted] •Microtubule modifications affect the size and dynamics of the disordered tails.•Polyglutamylation expands whereas polyglycylation collapses…”
Get full text

Reconciling the controversy regarding the functional importance of bullet- and football-shaped GroE complexes by Bigman, Lavi S., Horovitz, Amnon

“…The chaperonin GroEL and its co-chaperonin GroES form both GroEL–GroES bullet-shaped and GroEL–GroES2 football-shaped complexes. The residence time of protein…”
Get full text

Negatively charged, intrinsically disordered regions can accelerate target search by DNA-binding proteins by Wang, Xi, Bigman, Lavi S, Greenblatt, Harry M, Yu, Binhan, Levy, Yaakov, Iwahara, Junji

“…Abstract In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions (IDRs) with large negative charge, some of which involve a…”
Get full text

What Are the Molecular Requirements for Protein Sliding along DNA? by Bigman, Lavi S, Greenblatt, Harry M, Levy, Yaakov

“…DNA-binding proteins rely on linear diffusion along the longitudinal DNA axis, supported by their nonspecific electrostatic affinity for DNA, to search for…”
Get full text

Stability Effects of Protein Mutations: The Role of Long-Range Contacts by Bigman, Lavi S, Levy, Yaakov

“…Predicting the effect of a single point mutation on protein thermodynamic stability (ΔΔG) is an ongoing challenge with high relevance for both fundamental and…”
Get full text

Dynamic Autoinhibition of the HMGB1 Protein via Electrostatic Fuzzy Interactions of Intrinsically Disordered Regions by Wang, Xi, Greenblatt, Harry M., Bigman, Lavi S., Yu, Binhan, Pletka, Channing C., Levy, Yaakov, Iwahara, Junji

“…[Display omitted] •The intrinsically disordered regions (IDRs) of HMGB1 undergo fuzzy interactions.•Weak fuzzy interactions of the D/E repeats create strong…”
Get full text

Conformational Analysis of Charged Homo-Polypeptides by Bigman, Lavi S, Levy, Yaakov

“…Many proteins have intrinsically disordered regions (IDRs), which are often characterized by a high fraction of charged residues with polyampholytic (i.e.,…”
Get full text

Entropic Contributions to Protein Stability by Bigman, Lavi S., Levy, Yaakov

“…Thermodynamic stability is an important property of proteins that is linked to many of the trade‐offs that characterize a protein molecule and therefore its…”
Get full text

A cohort-based nutrition ECHO for community health workers by T. Thomas, Karmella, Friedman, Sarah A, J. Larson, Madalyn, C. Jorgensen, Troy, Sharma, Sneha, Smith, Amie, S. Lavi, Mordechai

“…Abstract Project Extension for Community Healthcare Outcomes (ECHO) Nevada applied the ECHO virtual hub-and-spoke telementoring model over nine 6-week cohorts…”
Get full text

Predictive modeling of gene mutations for the survival outcomes of epithelial ovarian cancer patients by Ma, Mirielle C, Lavi, Ethan S, Altwerger, Gary, Lin, Z Ping, Ratner, Elena S

“…Epithelial ovarian cancer (EOC) has a low overall survival rate, largely due to frequent recurrence and acquiring resistance to platinum-based chemotherapy…”
Get full text

Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events by Rubinshtein, Ronen, Kuvin, Jeffrey T., Soffler, Morgan, Lennon, Ryan J., Lavi, Shahar, Nelson, Rebecca E., Pumper, Geralyn M., Lerman, Lilach O., Lerman, Amir

“…Aims There is growing need for the identification of novel non-invasive methodologies for the identification of individuals at risk for adverse cardiovascular…”
Get full text

Identification and Rationalization of Kinetic Folding Intermediates for a Low-Density Lipoprotein Receptor Ligand-Binding Module by Szekely, Or, Armony, Gad, Olsen, Gregory Lars, Bigman, Lavi S, Levy, Yaakov, Fass, Deborah, Frydman, Lucio

“…Many mutations that cause familial hypercholesterolemia localize to ligand-binding domain 5 (LA5) of the low-density lipoprotein receptor, motivating…”
Get full text

Gene expression of non-homologous end-joining pathways in the prognosis of ovarian cancer by Lavi, Ethan S., Lin, Z. Ping, Ratner, Elena S.

“…Ovarian cancer is the deadliest gynecologic malignancy in women, with a 46% five-year overall survival rate. The objective of the study was to investigate the…”
Get full text

In silico screening identifies a novel small molecule inhibitor that counteracts PARP inhibitor resistance in ovarian cancer by Lin, Z. Ping, Al Zouabi, Nour N., Xu, Mark L., Bowen, Nicole E., Wu, Terence L., Lavi, Ethan S., Huang, Pamela H., Zhu, Yong-Lian, Kim, Baek, Ratner, Elena S.

“…Poly ADP-ribose polymerase (PARP) inhibitors are promising targeted therapy for epithelial ovarian cancer (EOC) with BRCA mutations or defective homologous…”
Get full text