Search Results - "Lavery, Madigan"
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Hyperactive Striatal Dopamine Signaling Observed in Huntington's Disease Mouse Models Prior to Motor Symptom Onset Can be Attenuated via Activation of M 4 Receptors
Published in The FASEB journal (01-05-2022)“…Almost all Huntington's Disease (HD) patients die within 10-30 years after symptom onset and currently there are no available treatments to slow, stop, or…”
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Journal Article -
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Associations of phosphorylated tau pathology with whole‐hemisphere ex vivo morphometry in 7 tesla MRI
Published in Alzheimer's & dementia (01-06-2023)“…Introduction Neurodegenerative disorders are associated with different pathologies that often co‐occur but cannot be measured specifically with in vivo…”
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Journal Article -
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3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming
Published in Journal of clinical and translational science (01-03-2019)“…OBJECTIVES/SPECIFIC AIMS: The objective of this study was to determine if dopamine signaling is altered in a mouse model displaying excessive self-grooming and…”
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Journal Article -
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Hyperactive Striatal Dopamine Signaling Observed in Huntington’s Disease Mouse Models Prior to Motor Symptom Onset Can be Attenuated via Activation of M4 Receptors
Published in The FASEB journal (01-05-2022)“…Almost all Huntington’s Disease (HD) patients die within 10‐30 years after symptom onset and currently there are no available treatments to slow, stop, or…”
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Journal Article -
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Optimized extraction of the medial temporal lobe for postmortem MRI based on custom 3D printed molds
Published in Alzheimer's & dementia (01-12-2020)“…Background Structural magnetic resonance imaging (MRI) biomarkers are important for early detection of Alzheimer’s Disease (AD). However, atrophy measures can…”
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Optimized extraction of the medial temporal lobe for postmortem MRI based on custom 3D printed molds: Neuroimaging / New imaging methods
Published in Alzheimer's & dementia (01-12-2020)Get full text
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Application of histopathologically derived 3D tau burden map as in‐vivo region of interest for biomarker analysis
Published in Alzheimer's & dementia (01-12-2021)“…Background Quantitative three‐dimensional maps of tau neurofibrillary tangles (NFT) burden derived from dense serial histology have potential application for…”
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Novel ex vivo MRI atlas of the medial temporal lobe can be used to characterize structural changes due to Alzheimer’s disease pathology
Published in Alzheimer's & dementia (01-12-2020)“…Background Finding effective biomarkers that can support early‐stage clinical trials is a major challenge in Alzheimer’s Disease (AD). MRI measures of…”
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High‐resolution postmortem MRI reveals TDP‐43 association with medial temporal lobe subregional atrophy
Published in Alzheimer's & dementia (01-12-2020)“…Background The medial temporal lobe (MTL) is a hotspot of different neurodegenerative pathologies, and recent studies have shown associations of severity of…”
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3D Mapping of TAU Neurofibrillary Tangle Pathology in the Human Medial Temporal Lobe
Published in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) (01-04-2020)“…Tau protein neurofibrillary tangles (NFT) are linked to neuronal and synaptic loss and cognitive decline in Alzheimer's disease (AD) and related dementias. In…”
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Conference Proceeding -
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Building an Ex Vivo Atlas of the Earliest Brain Regions Affected by Alzheimer's Disease Pathology
Published in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) (01-04-2020)“…Earliest neuropathological changes in Alzheimer's Disease (AD) emerge in the medial temporal lobe (MTL). In order for MRI biomarkers to detect changes linked…”
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Conference Proceeding