Search Results - "Lavery, G G"

Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy by Diguet, Nicolas, Trammell, Samuel A.J, Tannous, Cynthia, Deloux, Robin, Piquereau, Jérôme, Mougenot, Nathalie, Gouge, Anne, Gressette, Mélanie, Manoury, Boris, Blanc, Jocelyne, Breton, Marie, Decaux, Jean-François, Lavery, Gareth G, Baczkó, István, Zoll, Joffrey, Garnier, Anne, Li, Zhenlin, Brenner, Charles, Mericskay, Mathias

“…BACKGROUND:Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation…”
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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures by Elhassan, Yasir S., Kluckova, Katarina, Fletcher, Rachel S., Schmidt, Mark S., Garten, Antje, Doig, Craig L., Cartwright, David M., Oakey, Lucy, Burley, Claire V., Jenkinson, Ned, Wilson, Martin, Lucas, Samuel J.E., Akerman, Ildem, Seabright, Alex, Lai, Yu-Chiang, Tennant, Daniel A., Nightingale, Peter, Wallis, Gareth A., Manolopoulos, Konstantinos N., Brenner, Charles, Philp, Andrew, Lavery, Gareth G.

“…Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but…”
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11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy by Fenton, C G, Doig, C L, Fareed, S, Naylor, A, Morrell, A P, Addison, O, Wehmeyer, C, Buckley, C D, Cooper, M S, Lavery, G G, Raza, K, Hardy, R S

“…Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant…”
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AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner by Seabright, Alex P., Fine, Nicholas H. F., Barlow, Jonathan P., Lord, Samuel O., Musa, Ibrahim, Gray, Alexander, Bryant, Jack A., Banzhaf, Manuel, Lavery, Gareth G., Hardie, D. Grahame, Hodson, David J., Philp, Andrew, Lai, Yu‐Chiang

“…Mitophagy is a key process regulating mitochondrial quality control. Several mechanisms have been proposed to regulate mitophagy, but these have mostly been…”
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Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1 by Garten, Antje, Grohmann, Theresa, Kluckova, Katarina, Lavery, Gareth G, Kiess, Wieland, Penke, Melanie

“…Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to…”
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11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess by Morgan, Stuart A, McCabe, Emma L, Gathercole, Laura L, Hassan-Smith, Zaki K, Larner, Dean P, Bujalska, Iwona J, Stewart, Paul M, Tomlinson, Jeremy W, Lavery, Gareth G

“…The adverse metabolic effects of prescribed and endogenous glucocorticoid (GC) excess, Cushing syndrome, create a significant health burden. We found that…”
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Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis by Fenton, C G, Webster, J M, Martin, C S, Fareed, S, Wehmeyer, C, Mackie, H, Jones, R, Seabright, A P, Lewis, J W, Lai, Y C, Goodyear, C S, Jones, S W, Cooper, M S, Lavery, G G, Langen, R, Raza, K, Hardy, R S

“…Patients with rheumatoid arthritis (RA) experience extra-articular manifestations including osteoporosis and muscle wasting, which closely associate with…”
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The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism by Fletcher, Rachel S, Lavery, Gareth G

“…The concept of replenishing or elevating NAD+ availability to combat metabolic disease and ageing is an area of intense research. This has led to a need to…”
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Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension by Mollan, S. P., Wakerley, B. R., Alimajstorovic, Z., Mitchell, J., Ottridge, R., Yiangou, A., Thaller, M., Gupta, A., Grech, O., Lavery, G., Brock, K., Sinclair, A. J.

“…Objective Headache is the predominant disabler in idiopathic intracranial hypertension (IIH). The aim was to characterise headache and investigate the…”
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Sarcopenia in chronic liver disease: mechanisms and countermeasures by Allen, Sophie L, Quinlan, Jonathan I, Dhaliwal, Amritpal, Armstrong, Matthew J, Elsharkawy, Ahmed M, Greig, Carolyn A, Lord, Janet M, Lavery, Gareth G, Breen, Leigh

“…Sarcopenia, a condition of low muscle mass, quality, and strength, is commonly found in patients with cirrhosis and is associated with adverse clinical…”
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Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS) by Krone, Nils, Hughes, Beverly A., Lavery, Gareth G., Stewart, Paul M., Arlt, Wiebke, Shackleton, Cedric H.L.

“…Liquid chromatography tandem mass spectrometry (LC/MS/MS) is replacing classical methods for steroid hormone analysis. It requires small sample volumes and has…”
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Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation by Zeng, Xing, Jedrychowski, Mark P, Chen, Yi, Serag, Sara, Lavery, Gareth G, Gygi, Steve P, Spiegelman, Bruce M

“…Brown adipocytes display phenotypic plasticity, as they can switch between the active states of fatty acid oxidation and energy dissipation versus a more…”
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Erenumab for headaches in idiopathic intracranial hypertension: A prospective open‐label evaluation by Yiangou, Andreas, Mitchell, James L., Fisher, Claire, Edwards, Julie, Vijay, Vivek, Alimajstorovic, Zerin, Grech, Olivia, Lavery, Gareth G., Mollan, Susan P., Sinclair, Alexandra J.

“…Objective To determine the effectiveness of erenumab in treating headaches in idiopathic intracranial hypertension (IIH) in whom papilledema had resolved…”
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Alterations in metabolic flux in migraine and the translational relevance by Grech, Olivia, Sassani, Matilde, Terwindt, Gisela, Lavery, Gareth G., Mollan, Susan P., Sinclair, Alexandra J.

“…Background Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the…”
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Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice by Merk, Verena M., Phan, Truong San, Wiedmann, Alice, Hardy, Rowan S., Lavery, Gareth G., Brunner, Thomas

“…Background Extra-adrenal glucocorticoid (GC) synthesis at epithelial barriers, such as skin and intestine, has been shown to be important in the local…”
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Rapid isolation of respiring skeletal muscle mitochondria using nitrogen cavitation by Younis, Awais Z, Lavery, Gareth G, Christian, Mark, Doig, Craig L

“…Methods of isolating mitochondria commonly utilise mechanical force and shear stress to homogenize tissue followed by purification by multiple rounds of…”
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Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells by Fletcher, Rachel S, Ratajczak, Joanna, Doig, Craig L, Oakey, Lucy A, Callingham, Rebecca, da Silva Xavier, Gabriella, Garten, Antje, Elhassan, Yasir S, Redpath, Philip, Migaud, Marie E, Philp, Andrew, Brenner, Charles, Canto, Carles, Lavery, Gareth G

“…Abstract Objective Augmenting nicotinamide adenine dinucleotide (NAD+ ) availability may protect skeletal muscle from age-related metabolic decline. Dietary…”
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Calcitonin gene related peptide monoclonal antibody treats headache in patients with active idiopathic intracranial hypertension by Yiangou, Andreas, Mitchell, James L., Vijay, Vivek, Grech, Olivia, Bilton, Edward, Lavery, Gareth G., Fisher, Claire, Edwards, Julie, Mollan, Susan P., Sinclair, Alexandra J.

“…Background Headache is the dominant factor for quality of life related disability in idiopathic intracranial hypertension (IIH) and typically has migraine-like…”
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Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 Contributes to Epidermal Permeability Barrier Dysfunction in Aged Skin by Kim, Beom Jun, Lee, Noo Ri, Lee, Chung Hyeok, Lee, Young Bin, Choe, Sung Jay, Lee, Solam, Hwang, Hyun Jee, Kim, Eunjung, Lavery, Gareth G., Shin, Kyong-Oh, Park, Kyungho, Choi, Eung Ho

“…Inactive cortisone is converted into active cortisol by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Excessive levels of active glucocorticoids could…”
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11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice by Doig, Craig L., Fletcher, Rachel S., Morgan, Stuart A., McCabe, Emma L., Larner, Dean P., Tomlinson, Jeremy W., Stewart, Paul M., Philp, Andrew, Lavery, Gareth G.

“…Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with…”
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