Search Results - "Lavery, Derek N."

Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations by Lavery, Derek N, McEwan, Iain J

“…Steroid hormones are important endocrine signalling molecules controlling reproduction, development, metabolism, salt balance and specialized cellular…”
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Mini-review: Foldosome regulation of androgen receptor action in prostate cancer by Querol Cano, Laia, Lavery, Derek N., Bevan, Charlotte L.

“…► The simplistic view that chaperones act only in the cytoplasm has recently been overturned. ► The nuclear role of chaperones and foldosome proteins is…”
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Repression of Androgen Receptor Activity by HEYL, a Third Member of the Hairy/Enhancer-of-split-related Family of Notch Effectors by Lavery, Derek N., Villaronga, M. Angeles, Walker, Marjorie M., Patel, Anup, Belandia, Borja, Bevan, Charlotte L.

“…The Hairy/Enhancer-of-split-related with YRPW-like motif (HEY) family of proteins are transcriptional repressors and downstream effectors of Notch signaling…”
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Structural Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding by Lavery, Derek N., McEwan, Iain J.

“…The androgen receptor (AR) mediates the action of the steroid hormones testosterone and dihydrotestosterone. The protein contains two globular α-helical…”
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Androgen Receptor Signalling in Prostate Cancer : The Functional Consequences of Acetylation by Lavery, Derek N., Bevan, Charlotte L.

“…The androgen receptor (AR) is a ligand activated transcription factor and member of the steroid hormone receptor (SHR) subfamily of nuclear receptors. In the…”
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Functional Characterization of the Native NH2-Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a by Lavery, Derek N., McEwan, Iain J.

“…The androgen receptor (AR) is a ligand-activated transcription factor that mediates the actions of the steroid hormones testosterone and dihydrotestosterone at…”
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Role of the HSP90-Associated Cochaperone p23 in Enhancing Activity of the Androgen Receptor and Significance for Prostate Cancer by Reebye, Vikash, Querol Cano, Laia, Lavery, Derek N, Brooke, Greg N, Powell, Sue M, Chotai, Deepa, Walker, Marjorie M, Whitaker, Hayley C, Wait, Robin, Hurst, Helen C, Bevan, Charlotte L

“…Prostate tumor growth initially depends on androgens, which act via the androgen receptor (AR). Despite androgen ablation therapy, tumors eventually progress…”
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The co-chaperone p23 promotes prostate cancer motility and metastasis by Querol Cano, Laia, Lavery, Derek N., Sin, Soraya, Spanjaard, Emma, Brooke, Greg N., Tilman, Jessica D., Abroaf, Ahmed, Gaughan, Luke, Robson, Craig N., Heer, Rakesh, Mauri, Francesco, de Rooij, Johan, Driouch, Keltouma, Bevan, Charlotte L.

“…Prostate cancer is an androgen receptor (AR)-dependent malignancy at initiation and progression, therefore hormone therapy is the primary line of systemic…”
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Binding affinity and kinetic analysis of nuclear receptor/co-regulator interactions using surface plasmon resonance by Lavery, Derek N

“…Knowledge of the kinetics of protein-protein interactions has become important in defining nuclear receptor function. Such knowledge allows characterization of…”
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Control of Patterns of Corneal Innervation by Pax6 by Leiper, Lucy J, Ou, Jingxing, Walczysko, Petr, Kucerova, Romana, Lavery, Derek N, West, John D, Collinson, J. Martin

“…Corneal nerves play essential roles in maintaining the ocular surface through provision of neurotrophic support, but genetic control of corneal innervation is…”
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Engineered repressors are potent inhibitors of androgen receptor activity by Brooke, Greg N, Powell, Sue M, Lavery, Derek N, Waxman, Jonathan, Buluwela, Laki, Ali, Simak, Bevan, Charlotte L

“…Prostate cancer growth is dependent upon the Androgen Receptor (AR) pathway, hence therapies for this disease often target this signalling axis. Such therapies…”
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Negative Regulation of the Androgen Receptor Gene Through a Primate-Specific Androgen Response Element Present in the 5′ UTR by Hay, Colin W., Watt, Kate, Hunter, Irene, Lavery, Derek N., MacKenzie, Alasdair, McEwan, Iain J.

“…The androgen receptor (AR) is a widely expressed ligand-activated transcription factor which mediates androgen signalling by binding to androgen response…”
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Structural Characterization of the Native NH 2 -Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding by Lavery, Derek N., McEwan, Iain J.

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Functional Characterization of the Native NH 2 -Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a by Lavery, Derek N., McEwan, Iain J.

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Structural Characterization of the Native NH sub(2)-Terminal Transactivation Domain of the Human Androgen Receptor: A Collapsed Disordered Conformation Underlies Structural Plasticity and Protein-Induced Folding super([dagger]) by McEwan, Iain J, Lavery, Derek N

“…The androgen receptor (AR) mediates the action of the steroid hormones testosterone and dihydrotestosterone. The protein contains two globular alpha - helical…”
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Functional Characterization of the Native NH sub(2)-Terminal Transactivation Domain of the Human Androgen Receptor: Binding Kinetics for Interactions with TFIIF and SRC-1a super([dagger]) by McEwan, Iain J, Lavery, Derek N

“…The androgen receptor (AR) is a ligand-activated transcription factor that mediates the actions of the steroid hormones testosterone and dihydrotestosterone at…”
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