Search Results - "Laver, G"

BCX-1812 (RWJ-270201):  Discovery of a Novel, Highly Potent, Orally Active, and Selective Influenza Neuraminidase Inhibitor through Structure-Based Drug Design by Babu, Y. Sudhakar, Chand, Pooran, Bantia, Shanta, Kotian, Pravin, Dehghani, Ali, El-Kattan, Yahya, Lin, Tsu-Hsing, Hutchison, Tracy L, Elliott, Arthur J, Parker, Cynthia D, Ananth, Sandya L, Horn, LaShun L, Laver, Graeme W, Montgomery, John A

“…Hemagglutinin and neuraminidase (NA), the two glycoproteins on the surface of the influenza virus, have long been considered as potential antiviral targets…”
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Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors by Kim, Choung U, Lew, Willard, Williams, Matthew A, Wu, Huiwei, Zhang, Lijun, Chen, Xiaowu, Escarpe, Paul A, Mendel, Dirk B, Laver, W. Graeme, Stevens, Raymond C

“…A series of influenza neuraminidase inhibitors with the cyclohexene scaffold containing lipophilic side chains have been synthesized and evaluated for…”
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Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores by Wang, Gary T, Chen, Yuanwei, Wang, Sheldon, Gentles, Robert, Sowin, Thomas, Kati, Warren, Muchmore, Steve, Giranda, Vincent, Stewart, Kent, Sham, Hing, Kempf, Dale, Laver, W. Graeme

“…The discovery of (±)-(2S,3R,4R)-2-(trifluoroacetamido)methyl-3-amino-1-(N ‘-ethyl-N ‘-isopropylcarbamyl)pyrrolidine-4-carboxylic acid (A-192558, 20e) as a…”
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Crystal Structure of a Bacterial Sialidase (From Salmonella typhimurium LT2) Shows the Same Fold as an Influenza Virus Neuraminidase by Crennell, Susan J., Garman, Elspeth F., Laver, W. Graeme, Vimr, Eric R., Taylor, Garry L.

“…Sialidases (EC 3.2.1.18 or neuraminidases) remove sialic acid from sialoglycoconjugates, are widely distributed in nature, and have been implicated in the…”
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A Speed-Accuracy Analysis of Word Recognition in Young and Older Adults by Laver, Gary D

“…To measure age differences in the rate of semantic priming, studies vary the prime-target interval in lexical decision (LD) tasks. This provides no time limit…”
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Potent Inhibition of Influenza Sialidase by a Benzoic Acid Containing a 2-Pyrrolidinone Substituent by Atigadda, Venkatram R, Brouillette, Wayne J, Duarte, Franco, Ali, Shoukath M, Babu, Yarlagadda S, Bantia, Shanta, Chand, Pooran, Chu, Naiming, Montgomery, John A, Walsh, David A, Sudbeck, Elise A, Finley, James, Luo, Ming, Air, Gillian M, Laver, Graeme W

“…On the basis of the lead compound 4-(N-acetylamino)-3-guanidinobenzoic acid (BANA 113), which inhibits influenza A sialidase with a K i of 2.5 μM, several…”
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Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex by Tulip, W R, Varghese, J N, Laver, W G, Webster, R G, Colman, P M

“…The crystal structure of the complex between neuraminidase from influenza virus (subtype N9 and isolated from an avian source) and the antigen-binding fragment…”
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Hydrophobic benzoic acids as inhibitors of influenza neuraminidase by Atigadda, Venkatram R., Brouillette, Wayne J., Duarte, Franco, Babu, Yarlagadda S., Bantia, Shanta, Chand, Pooran, Chu, Naiming, Montgomery, John A., Walsh, David A., Sudbeck, Elise, Finley, James, Air, Gillian M., Luo, Ming, Laver, Graeme W.

“…Neuraminidase (NA) plays a critical role in the life cycle of influenza virus and is a target for new therapeutic agents. A new benzoic acid inhibitor (11 )…”
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Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 resolution by Varghese, J. N, Laver, W. G, Colman, P. M

“…The influenza virus neuraminidase glycoprotein is a tetramer with a box-shaped head, 100 X 100 X 60 A, attached to a slender stalk. The three-dimensional…”
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Structure of the catalytic and antigenic sites in influenza virus neuraminidase by Colman, P. M, Varghese, J. N, Laver, W. G

“…The catalytic sites of influenza virus neuraminidase are located on the upper corners of the box-shaped tetramer that forms the head of the molecule. Antigenic…”
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Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid by Bossart-Whitaker, P, Carson, M, Babu, Y S, Smith, C D, Laver, W G, Air, G M

“…We present here the three-dimensional structure of neuraminidase (E.C. 3.2.1.18) from influenza virus A/Tern/Australia/G70c/75 (N9), determined by the method…”
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Three-dimensional structure of a complex of antibody with influenza virus neuraminidase by Colman, P. M, Laver, W. G, Varghese, J. N, Baker, A. T, Tulloch, P. A, Air, G. M, Webster, R. G

“…The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of…”
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Novel α- and β-Amino Acid Inhibitors of Influenza Virus Neuraminidase by KATI, Warren M, MONTGOMERY, Debra, MARING, Clarence, STOLL, Vincent S, GIRANDA, Vincent, XIAOQI CHEN, LAVER, W. Graeme, KOHLBRENNER, William, NORBECK, Daniel W

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Design and Synthesis of Benzoic Acid Derivatives as Influenza Neuraminidase Inhibitors Using Structure-Based Drug Design by Chand, Pooran, Babu, Yarlagadda S, Bantia, Shanta, Chu, Naiming, Cole, L. Brent, Kotian, Pravin L, Laver, W. Graeme, Montgomery, John A, Pathak, Ved P, Petty, Sandra L, Shrout, David P, Walsh, David A, Walsh, Gerald M

“…A series of 94 benzoic acid derivatives was synthesized and tested for its ability to inhibit influenza neuraminidase. The enzyme−inhibitor complex structure…”
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How commercialization puts a blight on research by Laver, Graeme, Müllbacher, Arno, Waring, Paul

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Molecular mechanisms of variation in influenza viruses by Webster, R. G, Laver, W. G, Air, G. M, Schild, G. C

“…Influenza is unique among the viruses in its capacity to vary. Because of antigenic variation, it has proved impossible to control influenza by vaccination,…”
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Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants by Tulip, W R, Varghese, J N, Baker, A T, van Donkelaar, A, Laver, W G, Webster, R G, Colman, P M

“…The crystal structure of the N9 subtype neuraminidase of influenza virus was refined by simulated annealing and conventional techniques to an R-factor of 0.172…”
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Antigenicity of the N8 influenza A virus neuraminidase: existence of an epitope at the subunit interface of the neuraminidase by SAITO, T, TAYLOR, G, LAVER, W. G, KAWAOKA, Y, WEBSTER, R. G

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Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface by Tulip, W R, Varghese, J N, Webster, R G, Laver, W G, Colman, P M

“…The site on influenza virus N9 neuraminidase recognized by NC41 monoclonal antibody comprises 19 amino acid residues that are in direct contact with 17…”
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Isolation of a biologically active soluble form of the hemagglutinin-neuraminidase protein of Sendai virus by THOMPSON, S. D, LAVER, W. G, MURTI, K. G, PORTNER, A

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