Search Results - "Lavenir, Isabelle"

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy by SCHAEFFER, Veronique, LAVENIR, Isabelle, OZCELIK, Sefika, TOLNAY, Markus, WINKLER, David T, GOEDERT, Michel

“…The accumulation of insoluble proteins is a pathological hallmark of several neurodegenerative disorders. Tauopathies are caused by the dysfunction and…”
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"Prion-Like" Templated Misfolding in Tauopathies by Clavaguera, Florence, Lavenir, Isabelle, Falcon, Ben, Frank, Stephan, Goedert, Michel, Tolnay, Markus

“…The soluble microtubule‐associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases…”
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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice by Clavaguera, Florence, Hench, Jürgen, Lavenir, Isabelle, Schweighauser, Gabriel, Frank, Stephan, Goedert, Michel, Tolnay, Markus

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Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice by Lavenir, Isabelle, Passarella, Daniela, Masuda-Suzukake, Masami, Curry, Annabelle, Holton, Janice L, Ghetti, Bernardino, Goedert, Michel

“…Synucleinopathies [Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous α-synuclein assemblies in…”
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Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau by Schweighauser, Manuel, Murzin, Alexey G, Macdonald, Jennifer, Lavenir, Isabelle, Crowther, R Anthony, Scheres, Sjors H W, Goedert, Michel

“…Mice transgenic for human mutant P301S tau are widely used as models for human tauopathies. They develop neurodegeneration and abundant filamentous inclusions…”
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Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds by Macdonald, Jennifer A, Chen, John L, Masuda-Suzukake, Masami, Schweighauser, Manuel, Jaunmuktane, Zane, Warner, Thomas, Holton, Janice L, Grossman, Annabelle, Berks, Richard, Lavenir, Isabelle, Goedert, Michel

“…Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice…”
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Assembly of transgenic human P301S Tau is necessary for neurodegeneration in murine spinal cord by Macdonald, Jennifer A, Bronner, Iraad F, Drynan, Lesley, Fan, Juan, Curry, Annabelle, Fraser, Graham, Lavenir, Isabelle, Goedert, Michel

“…A pathological pathway leading from soluble monomeric to insoluble filamentous Tau is characteristic of many human neurodegenerative diseases, which also…”
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Analysis of Tau Phosphorylation and Truncation in a Mouse Model of Human Tauopathy by Delobel, Patrice, Lavenir, Isabelle, Fraser, Graham, Ingram, Esther, Holzer, Max, Ghetti, Bernardino, Spillantini, Maria Grazia, Crowther, R. Anthony, Goedert, Michel

“…Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the…”
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Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene] by Velasco, Ana, Fraser, Graham, Delobel, Patrice, Ghetti, Bernardino, Lavenir, Isabelle, Goedert, Michel

“…Filamentous inclusions made of the microtubule-associated protein tau in a hyperphosphorylated state are a defining feature of a large number of human…”
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Folding and Stability of a Primitive Protein by Riechmann, Lutz, Lavenir, Isabelle, de Bono, Stephanie, Winter, Greg

“…We have previously attempted to simulate domain creation in early protein evolution by recombining polypeptide segments from non-homologous proteins, and we…”
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A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity by Ahmed, Zeshan, Cooper, Jane, Murray, Tracey K., Garn, Katya, McNaughton, Emily, Clarke, Hannah, Parhizkar, Samira, Ward, Mark A., Cavallini, Annalisa, Jackson, Samuel, Bose, Suchira, Clavaguera, Florence, Tolnay, Markus, Lavenir, Isabelle, Goedert, Michel, Hutton, Michael L., O’Neill, Michael J.

“…Intracellular inclusions composed of hyperphosphorylated filamentous tau are a hallmark of Alzheimer’s disease, progressive supranuclear palsy, Pick’s disease…”
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α-Synuclein filaments from transgenic mouse and human synucleinopathy-containing brains are major seed-competent species by Morgan, Sophie A., Lavenir, Isabelle, Fan, Juan, Masuda-Suzukake, Masami, Passarella, Daniela, DeTure, Michael A., Dickson, Dennis W., Ghetti, Bernardino, Goedert, Michel

“…Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of…”
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Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains by Yang, Yang, Zhang, Wenjuan, Murzin, Alexey G., Schweighauser, Manuel, Huang, Melissa, Lövestam, Sofia, Peak-Chew, Sew Y., Saito, Takashi, Saido, Takaomi C., Macdonald, Jennifer, Lavenir, Isabelle, Ghetti, Bernardino, Graff, Caroline, Kumar, Amit, Nordberg, Agneta, Goedert, Michel, Scheres, Sjors H. W.

“…The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease…”
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Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with AppNL-G-F Mice by Huang, Melissa, Macdonald, Jennifer, Lavenir, Isabelle, Chen, Renren, Craxton, Molly, Slavik-Smith, Elizabeth, Davies, Stephen W., Goedert, Michel

“…Alzheimer’s Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which…”
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Cryo-EM structures of amyloid-β 42 filaments from human brain by Yang, Yang, Arseni, Diana, Zhang, Wenjuan, Huang, Melissa, Lövestam, Sofia, Schweighauser, Manuel, Kotecha, Abhay, Murzin, Alexey G., Peak-Chew, Sew Y., Macdonald, Jennifer, Lavenir, Isabelle, Garringer, Holly J., Gelpi, Ellen, Newell, Kathy L., Kovacs, Gabor G., Vidal, Ruben, Ghetti, Bernardino, Falcon, Benjamin, Scheres, Sjors H.W., Goedert, Michel

“…Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. We report the cryo-EM structures of Aβ42…”
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Cryo-EM structures of amyloid-β 42 filaments from human brains by Yang, Yang, Arseni, Diana, Zhang, Wenjuan, Huang, Melissa, Lövestam, Sofia, Schweighauser, Manuel, Kotecha, Abhay, Murzin, Alexey G, Peak-Chew, Sew Y, Macdonald, Jennifer, Lavenir, Isabelle, Garringer, Holly J, Gelpi, Ellen, Newell, Kathy L, Kovacs, Gabor G, Vidal, Ruben, Ghetti, Bernardino, Ryskeldi-Falcon, Benjamin, Scheres, Sjors H W, Goedert, Michel

“…Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. Here, we report the cryo–electron microscopy…”
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The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate by Bravo, Jerónimo, Karathanassis, Dimitrios, Pacold, Christine M, Pacold, Michael E, Ellson, Chris D, Anderson, Karen E, Butler, P.Jonathan G, Lavenir, Isabelle, Perisic, Olga, Hawkins, Phillip T, Stephens, Len, Williams, Roger L

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Assembly of [alpha]-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of [alpha]-synuclein seeds by Macdonald, Jennifer A, Chen, John L, Masuda-Suzukake, Masami, Schweighauser, Manuel, Jaunmuktane, Zane, Warner, Thomas, Holton, Janice L, Grossman, Annabelle, Berks, Richard, Lavenir, Isabelle, Goedert, Michel

“…Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T [alpha]-synuclein induced synucleinopathy in heterozygous mice…”
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Silver staining (Campbell-Switzer) of neuronal [alpha]-synuclein assemblies induced by multiple system atrophy and Parkinson's disease brain extracts in transgenic mice by Lavenir, Isabelle, Passarella, Daniela, Masuda-Suzukake, Masami, Curry, Annabelle, Holton, Janice L, Ghetti, Bernardino, Goedert, Michel

“…Synucleinopathies [Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA)] share filamentous [alpha]-synuclein assemblies…”
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Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice by Huang, Melissa, Macdonald, Jennifer, Lavenir, Isabelle, Chen, Renren, Craxton, Molly, Slavik-Smith, Elizabeth, Davies, Stephen W, Goedert, Michel

“…Alzheimer's Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which…”
Get full text