Search Results - "Lavender, Kerry"

Inducing Long-Term HIV-1 Latency in the TKO-BLT Mouse Model by Di, Yunyun, Lavender, Kerry J

“…Multiple humanized mouse models have been produced for the study of HIV-1 infection and treatment. Humanized mice produced using the bone marrow, liver, thymus…”
Get more information

Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice by Rout, Saurav S., Di, Yunyun, Dittmer, Ulf, Sutter, Kathrin, Lavender, Kerry J.

“…Interferon-alpha (IFN-α) has been associated with excessive immune activation and dysfunction during HIV-1 infection. However, evidence suggests specific IFN-α…”
Get full text

Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles by Malyshkina, Anna, Bayer, Wibke, Podschwadt, Philip, Otto, Lucas, Karakoese, Zehra, Sutter, Kathrin, Bruderek, Kirsten, Wang, Baoxiao, Lavender, Kerry J, Santiago, Mario L, Leipe, Pia Madeleine, Elsner, Carina, Esser, Stefan, Brandau, Sven, Gunzer, Matthias, Dittmer, Ulf

“…Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic condition. However, eliminating the virus remains an elusive therapy…”
Get full text

Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection by Schuhenn, Jonas, Meister, Toni Luise, Todt, Daniel, Bracht, Thilo, Schork, Karin, Billaud, Jean-Noel, Elsner, Carina, Heinen, Natalie, Karakoese, Zehra, Haid, Sibylle, Kumar, Sriram, Brunotte, Linda, Eisenacher, Martin, Di, Yunyun, Lew, Jocelyne, Falzarano, Darryl, Chen, Jieliang, Yuan, Zhenghong, Pietschmann, Thomas, Wiegmann, Bettina, Uebner, Hendrik, Taube, Christian, Le-Trilling, Vu Thuy Khanh, Trilling, Mirko, Krawczyk, Adalbert, Ludwig, Stephan, Sitek, Barbara, Steinmann, Eike, Dittmer, Ulf, Lavender, Kerry J, Sutter, Kathrin, Pfaender, Stephanie

“…Type I interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control versus immune-mediated pathologies, and have…”
Get full text

Pathogenicity of Ebola and Marburg Viruses Is Associated With Differential Activation of the Myeloid Compartment in Humanized Triple Knockout-Bone Marrow, Liver, and Thymus Mice by Lavender, Kerry J, Williamson, Brandi N, Saturday, Greg, Martellaro, Cynthia, Griffin, Amanda, Hasenkrug, Kim J, Feldmann, Heinz, Prescott, Joseph

“…Ebola virus (EBOV) and Marburg virus (MARV) outbreaks are highly lethal, and infection results in a hemorrhagic fever with complex etiology. These zoonotic…”
Get full text

Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection In Vivo by Lavender, Kerry J, Gibbert, Kathrin, Peterson, Karin E, Van Dis, Erik, Francois, Sandra, Woods, Tyson, Messer, Ronald J, Gawanbacht, Ali, Müller, Janis A, Münch, Jan, Phillips, Katie, Race, Brent, Harper, Michael S, Guo, Kejun, Lee, Eric J, Trilling, Mirko, Hengel, Hartmut, Piehler, Jacob, Verheyen, Jens, Wilson, Cara C, Santiago, Mario L, Hasenkrug, Kim J, Dittmer, Ulf

“…Although all 12 subtypes of human interferon alpha (IFN-α) bind the same receptor, recent results have demonstrated that they elicit unique host responses and…”
Get full text

Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2 by Francis, Magen E., Jansen, Ethan B., Yourkowski, Anthony, Selim, Alaa, Swan, Cynthia L., MacPhee, Brian K., Thivierge, Brittany, Buchanan, Rachelle, Lavender, Kerry J., Darbellay, Joseph, Rogers, Matthew B., Lew, Jocelyne, Gerdts, Volker, Falzarano, Darryl, Skowronski, Danuta M., Sjaarda, Calvin, Kelvin, Alyson A.

“…SARS-CoV-2 variants and seasonal coronaviruses continue to cause disease and coronaviruses in the animal reservoir pose a constant spillover threat…”
Get full text

Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir by Sutter, Kathrin, Lavender, Kerry J., Messer, Ronald J., Widera, Marek, Williams, Katie, Race, Brent, Hasenkrug, Kim J., Dittmer, Ulf

“…Combination antiretroviral therapy (cART) prevents HIV-1 replication but does not eliminate the latent reservoir and cure the infection. Type I interferons…”
Get full text

An advanced BLT-humanized mouse model for extended HIV-1 cure studies by Lavender, Kerry J, Pace, Craig, Sutter, Kathrin, Messer, Ronald J, Pouncey, Dakota L, Cummins, Nathan W, Natesampillai, Sekar, Zheng, Jim, Goldsmith, Joshua, Widera, Marek, Van Dis, Erik S, Phillips, Katie, Race, Brent, Dittmer, Ulf, Kukolj, George, Hasenkrug, Kim J

“…OBJECTIVE:Although bone marrow, liver, thymus (BLT)-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies…”
Get full text

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver by Spengler, Jessica R, Saturday, Greg, Lavender, Kerry J, Martellaro, Cynthia, Keck, James G, Nichol, Stuart T, Spiropoulou, Christina F, Feldmann, Heinz, Prescott, Joseph

“…Ebola virus, but not Reston virus, caused disease in NSG-SGM3 humanized mice, similar to infection in humans. Higher viral replication in liver and liver…”
Get full text

Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis by Guo, Kejun, Shen, Guannan, Kibbie, Jon, Gonzalez, Tania, Dillon, Stephanie M, Smith, Harry A, Cooper, Emily H, Lavender, Kerry, Hasenkrug, Kim J, Sutter, Kathrin, Dittmer, Ulf, Kroehl, Miranda, Kechris, Katerina, Wilson, Cara C, Santiago, Mario L

“…The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα subtypes and IFNβ that signal through the IFN-I receptor (IFNAR),…”
Get full text

SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model by Di, Yunyun, Lew, Jocelyne, Goncin, Una, Radomska, Anna, Rout, Saurav S, Gray, Bridget E. T, Machtaler, Steven, Falzarano, Darryl, Lavender, Kerry J

“…Small animal models that accurately model pathogenesis of SARS-CoV-2 variants are required for ongoing research efforts. We modified our human immune system…”
Get full text

Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection by Kramer, Holger B, Lavender, Kerry J, Qin, Li, Stacey, Andrea R, Liu, Michael K P, di Gleria, Katalin, Simmons, Alison, Gasper-Smith, Nancy, Haynes, Barton F, McMichael, Andrew J, Borrow, Persephone, Kessler, Benedikt M

“…The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or…”
Get full text

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment by Spengler, Jessica R., Lavender, Kerry J., Martellaro, Cynthia, Carmody, Aaron, Kurth, Andreas, Keck, James G., Saturday, Greg, Scott, Dana P., Nichol, Stuart T., Hasenkrug, Kim J., Spiropoulou, Christina F., Feldmann, Heinz, Prescott, Joseph

“…The study of Ebola virus (EBOV) pathogenesis in vivo has been limited to nonhuman primate models or use of an adapted virus to cause disease in rodent models…”
Get full text

Mice of the resistant H-2(b) haplotype mount broad CD4(+) T cell responses against 9 distinct Friend virus epitopes by Messer, Ronald J, Lavender, Kerry J, Hasenkrug, Kim J

“…To date, only a single Friend virus (FV) peptide recognized by CD4(+) T cells in FV-infected mice of the resistant H-2(b) haplotype has been described. To more…”
Get full text

The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research by Wozniak, David M, Lavender, Kerry J, Prescott, Joseph, Spengler, Jessica R

“…Human immune system (HIS) mice are a subset of humanized mice that are generated by xenoengraftment of human immune cells or tissues and/or their progenitors…”
Get full text

No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts by Dis, Erik S. Van, Moore, Tyler C, Lavender, Kerry J, Messer, Ronald J, Keppler, Oliver T, Verheyen, Jens, Dittmer, Ulf, Hasenkrug, Kim J

“…Abstract Amyloid fibrils from semen-derived peptide (SEVI) enhance HIV-1 infectivity in vitro but the ability of SEVI to mediate enhancement of HIV infection…”
Get full text

When the clock ticks wrong with COVID‐19 by Papagerakis, Silvana, Said, Raed, Ketabat, Farinaz, Mahmood, Razi, Pundir, Meenakshi, Lobanova, Liubov, Guenther, Greg, Pannone, Giuseppe, Lavender, Kerry, McAlpin, Blake R., Moreau, Alain, Chen, Xiongbiao, Papagerakis, Petros

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of the coronavirus family that causes the novel coronavirus disease first diagnosed in…”
Get full text

Mice of the resistant H-2b haplotype mount broad CD4+ T cell responses against 9 distinct Friend virus epitopes by Messer, Ronald J, Lavender, Kerry J, Hasenkrug, Kim J

“…Abstract To date, only a single Friend virus (FV) peptide recognized by CD4+ T cells in FV-infected mice of the resistant H-2b haplotype has been described. To…”
Get full text

Different Biological Activities of Specific Interferon Alpha Subtypes by Hasenkrug, Kim J, Lavender, Kerry J, Santiago, Mario L, Sutter, Kathrin, Dittmer, Ulf

Get full text