Abdominal aortic aneurysms in sheep: prevention of rupture with endoluminal stent-grafts

The authors evaluated the ability of an aortic balloon-expandable endovascular stent-graft to prevent rupture in a model of spontaneously rupturing abdominal aortic aneurysms in sheep. Aneurysms were created in 16 sheep by inserting a 60 x 18-mm segment of the left internal jugular vein, end-to-end...

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Bibliographic Details
Published in:	Radiology Vol. 206; no. 2; p. 447
Main Authors:	Boudghène, F P, Sapoval, M R, Bonneau, M, LeBlanche, A F, Lavaste, F C, Michel, J B
Format:	Journal Article
Language:	English
Published:	United States 01-02-1998
Subjects:	Animals Aortic Aneurysm, Abdominal - mortality Aortic Aneurysm, Abdominal - therapy Aortic Rupture - mortality Aortic Rupture - prevention & control Equipment Design Follow-Up Studies Polyethylene Terephthalates Sheep Stainless Steel Stents Survival Rate Time Factors
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Summary:	The authors evaluated the ability of an aortic balloon-expandable endovascular stent-graft to prevent rupture in a model of spontaneously rupturing abdominal aortic aneurysms in sheep. Aneurysms were created in 16 sheep by inserting a 60 x 18-mm segment of the left internal jugular vein, end-to-end anastomosed, to the sectioned infrarenal abdominal aorta. The sheep were randomly assigned into two groups; eight animals underwent endovascular implantation of an 80 x 12-mm balloon expandable stent-graft (group A), and eight were only followed up (group B). In group B, seven of eight animals had died of aneurysmal rupture by 3 months. In group A, six of the eight aortic aneurysms were immediately excluded, and six animals were alive at 3 months without rupture. The 3-month survival rate was 100% in group A and 12% in group B (P = .0023). Macro- and microscopic analysis of the section of the aorta in which the stent-graft had been placed revealed rapid retraction of the aneurysmal sac. Placement of an endovascular stent-graft induced regression of a branchless aneurysm and prevented rupture.
ISSN:	0033-8419
DOI:	10.1148/radiology.206.2.9457199