Search Results - "Lauzon, Sophie"

Sterically Biased 3,3-Sigmatropic Rearrangement of Chiral Allylic Azides: Application to the Total Syntheses of Alkaloids by Lauzon, Sophie, Tremblay, François, Gagnon, David, Godbout, Cédrickx, Chabot, Christine, Mercier-Shanks, Catherine, Perreault, Stéphane, DeSève, Hélène, Spino, Claude

“…We describe a tandem Mitsunobu/3,3-sigmatropic rearrangement of allylic azides on a chiral auxiliary system that favors one regioisomer thanks to its…”
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Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245 by Girardin, Mélina, Dolman, Sarah J, Lauzon, Sophie, Ouellet, Stéphane G, Hughes, Greg, Fernandez, Paul, Zhou, George, O’Shea, Paul D

“…A practical kilogram scale chromatography-free synthesis of stearoyl-CoA desaturase 1 (SCD1) inhibitor MK-8245 is described. The key features of this sequence…”
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Sterically Biased 3,3-Sigmatropic Rearrangement of Azides:  Efficient Preparation of Nonracemic α-Amino Acids and Heterocycles by Gagnon, David, Lauzon, Sophie, Godbout, Cédrickx, Spino, Claude

“…Homochiral α-amino acids, heterocycles, and carbocycles are efficiently constructed via a short sequence of reactions starting from the chiral auxiliary…”
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Synthesis of 3-Aminoisoxazoles via the Addition−Elimination of Amines on 3-Bromoisoxazolines by Girardin, Mélina, Alsabeh, Pamela G, Lauzon, Sophie, Dolman, Sarah J, Ouellet, Stéphane G, Hughes, Greg

“…A novel two-step procedure for the synthesis of 3-amino-5-substituted-isoxazoles is described. In the presence of a base, readily available 3-bromoisoxazolines…”
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Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines by Chen, Austin, Cauchon, Elizabeth, Chefson, Amandine, Dolman, Sarah, Ducharme, Yves, Dubé, Daniel, Falgueyret, Jean-Pierre, Fournier, Pierre-André, Gagné, Sébastien, Gallant, Michel, Grimm, Erich, Han, Yongxin, Houle, Robert, Huang, Jing-Qi, Hughes, Gregory, Jûteau, Hélène, Lacombe, Patrick, Lauzon, Sophie, Lévesque, Jean-François, Liu, Susana, MacDonald, Dwight, Mackay, Bruce, McKay, Dan, Percival, M. David, St-Jacques, René, Toulmond, Sylvie

“…The design and optimization of a novel series of renin inhibitor is described herein. Strategically, by committing the necessary resources to the development…”
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Remote Electronic Control in the Regioselective Reduction of Succinimides: A Practical, Scalable Synthesis of EP4 Antagonist MF-310 by Molinaro, Carmela, Gauvreau, Danny, Hughes, Gregory, Lau, Stephen, Lauzon, Sophie, Angelaud, Rémy, O’Shea, Paul D, Janey, Jacob, Palucki, Michael, Hoerrner, Scott R, Raab, Conrad E, Sidler, Rick R, Belley, Michel, Han, Yongxin

“…A practical large-scale chromatography-free synthesis of EP4 antagonist MF-310, a potential new treatment for chronic inflammation, is presented. The synthetic…”
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Cleavage of a chiral auxiliary using RCM on an especially sterically crowded alkene: Syntheses of chiral carbo- and heterocycles by Spino, Claude, Boisvert, Luc, Douville, Jasmin, Roy, Stéphanie, Lauzon, Sophie, Minville, Joannie, Gagnon, David, Beaumier, Francis, Chabot, Christine

“…RCM is used to cleave a chiral auxiliary and generate carbo- and heterocycles directly. The alkene bearing the auxiliary has an uncommon steric demand…”
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Réarrangement sigmatropique [3,3] d'azotures biaisés stériquement: Préparation d'acides aminés α-substitués et de N-hétérocycles by Lauzon, Sophie

“…Le premier chapitre de ce mémoire décrit la synthèse générale d'alcools allyliques disubstitués qui sont obtenus par addition de vinyllithiens sur un aldéhyde…”
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