Experimental immunity to Microsporum canis and cross reactions with other dermatophytes of veterinary importance

An inactivated, broad-spectrum dermatophyte vaccine was used to produce an active immunity in guinea-pigs against Microsporum canis. None of the vaccinates developed infection from a contact exposure challenge that produced clinical infections in 70% of the unvaccinated controls. Infection with M. c...

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Bibliographic Details
Published in:	Journal of medical and veterinary mycology Vol. 33; no. 2; p. 93
Main Authors:	Pier, A C, Hodges, A B, Lauze, J M, Raisbeck, M
Format:	Journal Article
Language:	English
Published:	England 01-03-1995
Subjects:	Animals Antigens, Fungal - immunology Arthrodermataceae - immunology Cross Reactions Dermatomycoses - immunology Dermatomycoses - pathology Dermatomycoses - prevention & control Fungal Vaccines - administration & dosage Fungal Vaccines - immunology Guinea Pigs Microsporum - immunology Rabbits Skin Tests
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Summary:	An inactivated, broad-spectrum dermatophyte vaccine was used to produce an active immunity in guinea-pigs against Microsporum canis. None of the vaccinates developed infection from a contact exposure challenge that produced clinical infections in 70% of the unvaccinated controls. Infection with M. canis induced antibody titres (ELISA) and delayed cutaneous hypersensitivity (DCH) reactions to itself as well as cross-reacting titres to Trichophyton equinum and T. mentagrophytes and DCH reactions to T. mentagrophytes; however vaccinated animals developed significantly higher antibody titres and DCH responses to all of these antigens than did non-vaccinated animals which had been infected or exposed. Rabbits hyperimmunized with culture filtrate antigens to single dermatophyte agents (M. canis, M. gypseum, T. equinum, and T. mentagrophytes) developed positive inter-species and inter-generic DCH cross-reactions to a battery of six skin test antigens (M. canis, M. gypseum, M. equinum, T. equinum, T. mentagrophytes var. mentagrophytes and T. verrucosum). Guinea-pigs vaccinated with a T. equinum vaccine had increased resistance to M. canis infection than did non-vaccinated controls. These findings support clinical observations which suggest establishment of a broad-based immunity in animals following infection with a single dermatophyte.
ISSN:	0268-1218