Search Results - "Laux, Valérie"
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Multi-lamellar organization of fully deuterated lipid extracts of yeast membranes
Published in Acta crystallographica. Section D, Biological crystallography. (01-12-2014)“…Neutron scattering studies on mimetic biomembranes are currently limited by the low availability of deuterated unsaturated lipid species. In the present work,…”
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2
Strikingly Different Roles of SARS-CoV‑2 Fusion Peptides Uncovered by Neutron Scattering
Published in Journal of the American Chemical Society (23-02-2022)“…Coronavirus disease-2019 (COVID-19), a potentially lethal respiratory illness caused by the coronavirus SARS-CoV-2, emerged in the end of 2019 and has since…”
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3
Biomolecular Deuteration for Neutron Structural Biology and Dynamics
Published in Methods in enzymology (01-01-2016)“…Neutron scattering studies provide important information in structural biology that is not accessible using other approaches. The uniqueness of the technique,…”
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4
Investigation on the relationship between lipid composition and structure in model membranes composed of extracted natural phospholipids
Published in Journal of colloid and interface science (01-05-2023)“…[Display omitted] Unravelling the structural diversity of cellular membranes is a paramount challenge in life sciences. In particular, lipid composition…”
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5
The impact of deuteration on natural and synthetic lipids: A neutron diffraction study
Published in Colloids and surfaces, B, Biointerfaces (01-08-2018)“…[Display omitted] •Neutron diffraction used to investigate natural and synthetic lipid mixtures.•Extracts composition changes for cells grown in deuterated or…”
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6
Developing advanced models of biological membranes with hydrogenous and deuterated natural glycerophospholipid mixtures
Published in Journal of colloid and interface science (01-09-2023)“…Cellular membranes are complex systems that consist of hundreds of different lipid species. Their investigation often relies on simple bilayer models including…”
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The impact of folding modes and deuteration on the atomic resolution structure of hen egg‐white lysozyme
Published in Acta crystallographica. Section D, Biological crystallography. (01-12-2021)“…The biological function of a protein is intimately related to its structure and dynamics, which in turn are determined by the way in which it has been folded…”
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8
Production and analysis of perdeuterated lipids from Pichia pastoris cells
Published in PloS one (01-04-2014)“…Probing molecules using perdeuteration (i.e deuteration in which all hydrogen atoms are replaced by deuterium) is extremely useful in a wide range of…”
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9
Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry
Published in Scientific reports (21-07-2021)“…SARS-CoV-2 spike proteins are responsible for the membrane fusion event, which allows the virus to enter the host cell and cause infection. This process starts…”
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10
Comparative Study of Polyethylene Films Embedded with Oxide Nanoparticles of Granulated and Free-Standing Nature
Published in Polymers (28-06-2022)“…Nanocomposite polymer films are a very diverse research field due to their many applications. The search for low-cost, versatile methods, producing regulated…”
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11
Adsorption of Denaturated Lysozyme at the Air–Water Interface: Structure and Morphology
Published in Langmuir (01-05-2018)“…The application of protein deuteration and high flux neutron reflectometry has allowed a comparison of the adsorption properties of lysozyme at the air–water…”
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12
The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry
Published in Nanomaterials (Basel, Switzerland) (06-12-2020)“…We have characterized and compared the structures of ergosterol- and cholesterol-containing 1-palmitoyl-2-oleoyl- -glycero-3-phosphocholine (POPC) membranes…”
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13
Structural Characterization of Natural Yeast Phosphatidylcholine and Bacterial Phosphatidylglycerol Lipid Multilayers by Neutron Diffraction
Published in Frontiers in chemistry (18-03-2021)“…Eukaryotic and prokaryotic cell membranes are difficult to characterize directly with biophysical methods. Membrane model systems, that include fewer molecular…”
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14
Structural insights into protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme
Published in IUCrJ (01-05-2021)“…This structural and biophysical study exploited a method of perdeuterating hen egg-white lysozyme based on the expression of insoluble protein in followed by…”
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15
Helicity of the SmCalpha phase and its variations in a thiobenzoate series
Published in Liquid crystals (01-03-1999)“…We have studied by optical means a thiobenzoate series exhibiting SmCA*, SmC*, SmCFI* and SmC*alpha phases. We have made pitch measurements on the SmCA* and…”
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16
Mobility of a Mononucleotide within a Lipid Matrix: A Neutron Scattering Study
Published in Life (Basel, Switzerland) (04-01-2017)“…An essential question in studies on the origins of life is how nucleic acids were first synthesized and then incorporated into compartments about 4 billion…”
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Lipid polyunsaturation determines the extent of membrane structural changes induced by Amphotericin B in Pichia pastoris yeast
Published in Biochimica et biophysica acta (01-10-2015)“…The activity of the potent but highly toxic antifungal drug Amphotericin B (AmB), used intravenously to treat systemic fungal and parasitic infections, is…”
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18
Blue phases and twist grain boundary phases (TGBA and TGBC) in a series of fluoro-substituted chiral tolane derivatives
Published in Liquid crystals (01-09-1997)“…A series of fluoro-substituted tolane derivatives: (R)-1-methylheptyl 3-fluoro-4-(3-fluoro-4- n alkoxybenzoyloxy)tolane-4-carboxylates is reported. Some…”
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19
Protein Short-Time Diffusion in a Naturally Crowded Environment
Published in The journal of physical chemistry letters (18-04-2019)“…The interior of living cells is a dense and polydisperse suspension of macromolecules. Such a complex system challenges an understanding in terms of colloidal…”
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20
Deuterium effects on human serum albumin in solution
Published in Physica. B, Condensed matter (15-12-2018)“…White et al report the thermodynamic effects of heavy water and intramolecular deuteration on the melting and aggregation of fatted and defatted human serum…”
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