Search Results - "Lauterwasser, Joachim"

Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
Get full text

Parkin promotes proteasomal degradation of misregulated BAX by Cakir, Zeynep, Funk, Kathrin, Lauterwasser, Joachim, Todt, Franziska, Zerbes, Ralf M, Oelgeklaus, Aline, Tanaka, Atsushi, van der Laan, Martin, Edlich, Frank

“…The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to…”
Get full text

The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation by Lauterwasser, Joachim, Todt, Franziska, Zerbes, Ralf M., Nguyen, Thanh Ngoc, Craigen, William, Lazarou, Michael, van der Laan, Martin, Edlich, Frank

“…The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane and therefore commit human cells to apoptosis. Bax is regulated by…”
Get full text

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals by Bruns, Oliver T, Ittrich, Harald, Peldschus, Kersten, Kaul, Michael G, Tromsdorf, Ulrich I, Lauterwasser, Joachim, Nikolic, Marija S, Mollwitz, Birgit, Merkel, Martin, Bigall, Nadja C, Sapra, Sameer, Reimer, Rudolph, Hohenberg, Heinz, Weller, Horst, Eychmüller, Alexander, Adam, Gerhard, Beisiegel, Ulrike, Heeren, Joerg

“…Semiconductor quantum dots and superparamagnetic iron oxide nanocrystals have physical properties that are well suited for biomedical imaging. Previously, we…”
Get full text

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals by Bruns, Oliver T., Ittrich, Harald, Peldschus, Kersten, Kaul, Michael G., Tromsdorf, Ulrich I., Lauterwasser, Joachim, Nikolic, Marija S., Mollwitz, Birgit, Merkel, Martin, Bigall, Nadja C., Sapra, Sameer, Reimer, Rudolph, Hohenberg, Heinz, Weller, Horst, Eychmüller, Alexander, Adam, Gerhard, Beisiegel, Ulrike, Heeren, Joerg

Get full text

Assessment of Dynamic BCL-2 Protein Shuttling Between Outer Mitochondrial Membrane and Cytosol by Lauterwasser, Joachim, Fimm-Todt, Franziska, Edlich, Frank

“…BCL-2 proteins control stress-dependent commitment to the programmed cell death apoptosis. In nonapoptotic cells the proapoptotic BCL-2 proteins BAX and BAK…”
Get more information

Identification of a novel Bax-Cdk1 signalling complex that links activation of the mitotic checkpoint to apoptosis by Darweesh, Omeed, Al-Shehri, Eman, Falquez, Hugo, Lauterwasser, Joachim, Edlich, Frank, Patel, Rajnikant

“…In eukaryotes, entry into and exit from mitosis is regulated, respectively, by the transient activation and inactivation of Cdk1. Taxol, an anti-microtubule…”
Get full text

Hexokinases inhibit death receptor–dependent apoptosis on the mitochondria by Lauterwasser, Joachim, Fimm-Todt, Franziska, Oelgeklaus, Aline, Schreiner, Annabell, Funk, Kathrin, Falquez-Medina, Hugo, Klesse, Ramona, Jahreis, Günther, Zerbes, Ralf M., O’Neill, Katelyn, van der Laan, Martin, Luo, Xu, Edlich, Frank

“…Death receptor–mediated apoptosis requires the mitochondrial apoptosis pathway in many mammalian cells. In response to death receptor signaling, the truncated…”
Get full text

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes by Andreu-Fernández, Vicente, Sancho, Mónica, Genovés, Ainhoa, Lucendo, Estefanía, Todt, Franziska, Lauterwasser, Joachim, Funk, Kathrin, Jahreis, Günther, Pérez-Payá, Enrique, Mingarro, Ismael, Edlich, Frank, Orzáez, Mar

“…The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane…”
Get full text

The binding mode of the natural compound ilicicolin H to the Qi site of the mitochondrial cytochrome bc1 complex by Kao, Wei-Chun, Birth, Dominic, Lauterwasser, Joachim, Reichenbach, Frank, Edlich, Frank, Hunte, Carola

Get full text

Abstract 549: Characterization of the selective inhibitory effect of KRas inhibitors in different cellular assay formats by Fimm-Todt, Franziska, Dikici, Ezgi, Schaich, Katharina, Siedentopf, Oliver, Lauterwasser, Joachim, Feger, Daniel, Ehlert, Jan Erik

“…Abstract The proto-oncogene KRas is a well-described small GTPase that functions as a molecular switch for major physiological signaling pathways involved in…”
Get full text

BAX Redistribution Induces Apoptosis Resistance and Selective Stress Sensitivity in Human HCC by Funk, Kathrin, Czauderna, Carolin, Klesse, Ramona, Becker, Diana, Hajduk, Jovana, Oelgeklaus, Aline, Reichenbach, Frank, Fimm-Todt, Franziska, Lauterwasser, Joachim, Galle, Peter R., Marquardt, Jens U., Edlich, Frank

“…Cancer therapies induce differential cell responses, ranging from efficient cell death to complete stress resistance. The BCL-2 proteins BAX and BAK govern the…”
Get full text

Abstract 2318: Real-time quantitative PCR based analysis of transcriptional effects of CDK8/Cyclin C inhibitors by Jordt, Laura M., Totzke, Frank, Lauterwasser, Joachim, Ehlert, Jan E., Hekking, Koen, Aerts, Bas, Obodozie, Cynthia, Weber, Holger, Müller, Gerhard, Kubbutat, Michael H.

“…Abstract CDK8 has been identified as being frequently upregulated in various types of human cancer such as colorectal cancer, certain sub-types of breast…”
Get full text

Abstract 4072: Cytotoxic effects of LRRK2 inhibitors in combined treatment with chemotherapeutic agents on a large panel of cancer cell lines by Fimm-Todt, Franziska, Lauterwasser, Joachim, Egenter, Eva-Maria, Weber, Christian, Feger, Daniel, Schaich, Katharina, Ulrich, Sarah, Siedentopf, Oliver, Totzke, Frank, Kubbutat, Michael, Ehlert, Jan Erik

“…Abstract Leucin-rich repeat kinase 2 (LRRK2) plays an important role in the onset of sporadic as well as familial Parkinson’s disease. Pathogenic…”
Get full text