Search Results - "Lauterburg, B H"

Pharmacokinetics and organ distribution of intravenous and oral methylene blue by PETER, C, HONGWAN, D, KÜPFER, A, LAUTERBURG, B. H

“…To determine the pharmacokinetics and organ distribution of i.v. and oral methylene blue, which is used to prevent ifosfamide-induced encephalopathy in…”
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Kava hepatotoxicity by Russmann, S, Lauterburg, B H, Helbling, A

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Cellular immunity in healthy volunteers treated with an octavalent conjugate Pseudomonas aeruginosa vaccine by Zuercher, A. W., Imboden, M. A., Jampen, S., Bosse, D., Ulrich, M., Chtioui, H., Lauterburg, B. H., Lang, A. B.

“…Summary Humoral immunity in response to an octavalent O‐polysaccharide‐toxin A conjugate Pseudomonas aeruginosa vaccine is well studied, and a phase III…”
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Compartmentation of Glutathione: Implications for the Study of Toxicity and Disease by Smith, Charles V., Jones, Dean P., Guenthner, Thomas M., Lash, Lawrence H., Lauterburg, Bernhard H.

“…The fact that glutathione (GSH) plays many roles in biological protective mechanisms and critical physiological functions has been recognized for decades…”
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The systemic availability of oral glutathione by WITSCHI, A, REDDY, S, STOFER, B, LAUTERBURG, B. H

“…When the plasma glutathione concentration is low, such as in patients with HIV infection, alcoholics, and patients with cirrhosis, increasing the availability…”
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Cellular immunity in healthy volunteers treated with an octavalent conjugate Pseudomonas aeruginosa vaccine by Zuercher, A. W., Imboden, M. A., Jampen, S., Bosse, D., Ulrich, M., Chtioui, H., Lauterburg, B. H., Lang, A. B.

“…Summary Humoral immunity in response to an octavalent O‐polysaccharide‐toxin A conjugate Pseudomonas aeruginosa vaccine is well studied, and a Phase III…”
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Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity by Lauterburg, B H, Velez, M E

“…Patients chronically abusing ethanol are more susceptible to the hepatotoxic effects of paracetamol. This could be due to an increased activation of the drug…”
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Decreased glutathione in patients with anorexia nervosa. Risk factor for toxic liver injury? by ZENGER, F, RUSSMANN, S, JUNKER, E, WÜTHRICH, C, BUI, M. H, LAUTERBURG, B. H

“…To investigate glutathione and amino acids related to glutathione metabolism in patients with anorexia nervosa in order to test the hypothesis that these…”
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Reperfusion Injury of the Liver: Role of Mitochondria and Protection by Glutathione Ester by Grattagliano, Ignazio, Vendemiale, Gianluigi, Lauterburg, Bernhard H.

“…Background. Reperfusion injury of the liver is characterized by intravascular oxidative stress and GSH consumption. Whether mitochondria contribute to…”
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Decreased release of glutathione into the systemic circulation of patients with HIV infection by Helbling, B, von Overbeck, J, Lauterburg, B H

“…Low glutathione (GSH) in patients with HIV infection could contribute to their immune deficiency since GSH plays an important role in the function of…”
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Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine by de Quay, B, Malinverni, R, Lauterburg, B H

“…To determine whether a single oral dose of N-acetylcysteine corrects the deficiency of cysteine and glutathione in plasma and mononuclear cells of HIV-infected…”
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Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress by Adams, Jr, J D, Lauterburg, B H, Mitchell, J R

“…Plasma GSH and GSSG concentrations were examined after the administration of compounds that deplete intracellular GSH either by adduct formation or by…”
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Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration by BURGUNDER, J. M, VARRIALE, A, LAUTERBURG, B. H

“…The effect of oral N-acetyl-L-cysteine (NAC) on plasma sulphhydryls has been studied in healthy volunteers. Following NAC 30 mg.kg-1, total NAC in plasma (i.e…”
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L-2-oxothiazolidine-4-carboxylic acid, a cysteine prodrug: pharmacokinetics and effects on thiols in plasma and lymphocytes in human by Porta, P, Aebi, S, Summer, K, Lauterburg, B H

“…L-2-oxothiazolidine-4-carboxylic acid (OTC), a prodrug of cysteine, was administered at a dose of 0.15 and 0.45 mmol/kg to healthy volunteers. The plasma…”
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Divergent effects of intravenous GSH and cysteine on renal and hepatic GSH by Aebi, S, Lauterburg, B H

“…There is a growing interest in the therapeutic use of sulfhydryls. To assess the effect of glutathione (GSH) and cysteine on the cellular thiol status, thiols…”
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Thiodiglycolic Acid is Excreted by Humans Receiving Ifosfamide and Inhibits Mitochondrial Function in Rats by VISARIUS, T. M, BÄHLER, H, KÜPFER, A, CERNY, T, LAUTERBURG, B. H

“…Thiodiglycolic acid has been identified as a major metabolite of the anticancer drug ifosfamide in humans. Patients treated with 12–16 g ifosfamide/m 2 ·day…”
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Increased urinary losses of carnitine during ifosfamide chemotherapy by MARTHALER, N. P, VISARIUS, T, KÜPFER, A, LAUTERBURG, B. H

“…Chloroacetaldehyde and thiodiglycolic acid, two metabolites of ifosfamide, interfere with mitochondrial function and may sequester carnitine. Urinary excretion…”
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Biliary excretion of glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress by LAUTERBURG, B. H, SMITH, C. V, HUGHES, H, MITCHELL, J. R

“…Regulation of the biliary excretion of reduced glutathione (GSH) and glutathione disulfide (GSSG) and responses to selected model toxins were examined in male…”
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Disposition of glutathione monoethyl ester in the rat: glutathione ester is a slow release form of extracellular glutathione by Grattagliano, I, Wieland, P, Schranz, C, Lauterburg, B H

“…Glutathione monethyl ester (GSHE) is though to deliver glutathione (GSH) directly and intact into cell cytosol and therefore might have therapeutic potential…”
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Depletion of circulating cyst(e)ine by oral and intravenous mesna by STOFER-VOGEL, B, CERNY, T, KÜPFER, A, JUNKER, E, LAUTERBURG, B. H

“…The sulfhydryl status of normal and tumour cells is critically important in determining their susceptibility to various cytostatic agents. As a sulfhydryl…”
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