Search Results - "Lauterbach, Mario A.R."

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages by Palsson-McDermott, Eva M., Curtis, Anne M., Goel, Gautam, Lauterbach, Mario A.R., Sheedy, Frederick J., Gleeson, Laura E., van den Bosch, Mirjam W.M., Quinn, Susan R., Domingo-Fernandez, Raquel, Johnston, Daniel G.W., Jiang, Jian-kang, Israelsen, William J., Keane, Joseph, Thomas, Craig, Clish, Clary, Vander Heiden, Matthew, Xavier, Ramnik J., O’Neill, Luke A.J.

“…Macrophages activated by the TLR4 agonist LPS undergo dramatic changes in their metabolic activity. We here show that LPS induces expression of the key…”
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Interferons and inflammasomes: Cooperation and counterregulation in disease by Labzin, Larisa I., PhD, Lauterbach, Mario A.R., MSc, Latz, Eicke, MD, PhD

“…Interferons and the IL-1 family of cytokines have important roles in host defense against invading viruses and bacteria. Inflammasomes, multimeric cytosolic…”
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Macrophage function in obesity-induced inflammation and insulin resistance by Lauterbach, Mario A. R., Wunderlich, F. Thomas

“…The steadily increasing obesity epidemic affects currently 30% of western populations and is causative for numerous disorders. It has been demonstrated that…”
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Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2 by Sander, Jil, Schmidt, Susanne V., Cirovic, Branko, McGovern, Naomi, Papantonopoulou, Olympia, Hardt, Anna-Lena, Aschenbrenner, Anna C., Kreer, Christoph, Quast, Thomas, Xu, Alexander M., Schmidleithner, Lisa M., Theis, Heidi, Thi Huong, Lan Do, Sumatoh, Hermi Rizal Bin, Lauterbach, Mario A.R., Schulte-Schrepping, Jonas, Günther, Patrick, Xue, Jia, Baßler, Kevin, Ulas, Thomas, Klee, Kathrin, Katzmarski, Natalie, Herresthal, Stefanie, Krebs, Wolfgang, Martin, Bianca, Latz, Eicke, Händler, Kristian, Kraut, Michael, Kolanus, Waldemar, Beyer, Marc, Falk, Christine S., Wiegmann, Bettina, Burgdorf, Sven, Melosh, Nicholas A., Newell, Evan W., Ginhoux, Florent, Schlitzer, Andreas, Schultze, Joachim L.

“…Human in vitro generated monocyte-derived dendritic cells (moDCs) and macrophages are used clinically, e.g., to induce immunity against cancer. However, their…”
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Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction by Alecu, Irina, Tedeschi, Andrea, Behler, Natascha, Wunderling, Klaus, Lamberz, Christian, Lauterbach, MarioA.R., Gaebler, Anne, Ernst, Daniela, Van Veldhoven, Paul P., Al-Amoudi, Ashraf, Latz, Eicke, Othman, Alaa, Kuerschner, Lars, Hornemann, Thorsten, Bradke, Frank, Thiele, Christoph, Penno, Anke

“…1-Deoxysphingolipids (deoxySLs) are atypical sphingolipids that are elevated in the plasma of patients with type 2 diabetes and hereditary sensory and…”
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Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming by Christ, Anette, Günther, Patrick, Lauterbach, Mario A.R., Duewell, Peter, Biswas, Debjani, Pelka, Karin, Scholz, Claus J., Oosting, Marije, Haendler, Kristian, Baßler, Kevin, Klee, Kathrin, Schulte-Schrepping, Jonas, Ulas, Thomas, Moorlag, Simone J.C.F.M., Kumar, Vinod, Park, Min Hi, Joosten, Leo A.B., Groh, Laszlo A., Riksen, Niels P., Espevik, Terje, Schlitzer, Andreas, Li, Yang, Fitzgerald, Michael L., Netea, Mihai G., Schultze, Joachim L., Latz, Eicke

“…Long-term epigenetic reprogramming of innate immune cells in response to microbes, also termed “trained immunity,” causes prolonged altered cellular…”
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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages by Palsson-McDermott, Eva M., Curtis, Anne M., Goel, Gautam, Lauterbach, Mario A.R., Sheedy, Frederick J., Gleeson, Laura E., van den Bosch, Mirjam W.M., Quinn, Susan R., Domingo-Fernandez, Raquel, Johnston, Daniel G.W., Jiang, Jian-kang, Israelsen, William J., Keane, Joseph, Thomas, Craig, Clish, Clary, Vander Heiden, Matthew, Xavier, Ramnik J., O’Neill, Luke A.J.

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