Search Results - "Lauro, Roberto Di"

Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms by De Felice, Mario, Di Lauro, Roberto

“…Thyroid gland organogenesis results in an organ the shape, size, and position of which are largely conserved among adult individuals of the same species, thus…”
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Minireview: Intrinsic and Extrinsic Factors in Thyroid Gland Development: An Update by De Felice, Mario, Di Lauro, Roberto

“…In vertebrates the portion of the thyroid gland synthesizing the thyroid hormones develops from a small group of endodermal cells in the foregut. The nature of…”
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The microRNA-processing enzyme Dicer is essential for thyroid function by Frezzetti, Daniela, Reale, Carla, Calì, Gaetano, Nitsch, Lucio, Fagman, Henrik, Nilsson, Ola, Scarfò, Marzia, De Vita, Gabriella, Di Lauro, Roberto

“…Dicer is a type III ribonuclease required for the biogenesis of microRNAs (miRNAs), a class of small non-coding RNAs regulating gene expression at the…”
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Transcriptional Control of the Forkhead Thyroid Transcription Factor TTF-2 by Thyrotropin, Insulin, and Insulin-like Growth Factor I by Ortiz, Lourdes, Zannini, Mariastella, Di Lauro, Roberto, Santisteban, Pilar

“…The hormonal regulation of both thyroglobulin and thyroperoxidase promoter activity in FRTL-5 thyroid cells takes place, at least in part, through a…”
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An integrated regulatory network controlling survival and migration in thyroid organogenesis by Parlato, Rosanna, Rosica, Annamaria, Rodriguez-Mallon, Alina, Affuso, Andrea, Postiglione, Maria Pia, Arra, Claudio, Mansouri, Ahmed, Kimura, Shioko, Di Lauro, Roberto, De Felice, Mario

“…The thyroid gland originates from the ventral floor of the foregut as a thickening of the endodermal cell layer. The molecular mechanisms underlying the early…”
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Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation by COBELLIS, G, MISSERO, C, DI LAURO, R

“…Activating point mutations in the Ras oncogene occur in a large number of human tumors, especially of epithelial origin. In thyroid follicular cells, ectopic…”
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Pax8 Has a Key Role in Thyroid Cell Differentiation by di Magliano, Marina Pasca, Di Lauro, Roberto, Zannini, Mariastella

“…Transformation of rat thyroid cells with polyoma virus middle T antigen results in loss of the thyroid-differentiated phenotype, measured as the expression of…”
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Missense Mutation in the Transcription Factor NKX2–5: A Novel Molecular Event in the Pathogenesis of Thyroid Dysgenesis by Dentice, Monica, Cordeddu, Viviana, Rosica, Annamaria, Ferrara, Alfonso Massimiliano, Santarpia, Libero, Salvatore, Domenico, Chiovato, Luca, Perri, Anna, Moschini, Lidia, Fazzini, Cristina, Olivieri, Antonella, Costa, Pietro, Stoppioni, Vera, Baserga, Mariangiola, De Felice, Mario, Sorcini, Mariella, Fenzi, Gianfranco, Di Lauro, Roberto, Tartaglia, Marco, Macchia, Paolo Emidio

“…Context: Congenital hypothyroidism (CH) is a common endocrine disorder with an incidence of 1:3000–4000 at birth. In 80–85% of cases, CH is caused by defects…”
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Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice by Potenza, Nicoletta, Vecchione, Carmine, Notte, Antonella, De Rienzo, Assunta, Rosica, Annamaria, Bauer, Lisa, Affuso, Andrea, De Felice, Mario, Russo, Tommaso, Poulet, Roberta, Cifelli, Giuseppe, De Vita, Gabriella, Lembo, Giuseppe, Di Lauro, Roberto

“…Ras proteins are highly related GTPases that have key roles in regulating growth, differentiation and tumorigenesis. Gene‐targeting experiments have shown…”
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A Mouse Model Demonstrates a Multigenic Origin of Congenital Hypothyroidism by Amendola, Elena, De Luca, Pasquale, Macchia, Paolo Emidio, Terracciano, Daniela, Rosica, Annamaria, Chiappetta, Gennaro, Kimura, Shioko, Mansouri, Ahmed, Affuso, Andrea, Arra, Claudio, Macchia, Vincenzo, Di Lauro, Roberto, De Felice, Mario

“…Congenital hypothyroidism with thyroid dysgenesis (TD) is a frequent human condition characterized by elevated levels of TSH in response to reduced thyroid…”
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Erratum to: In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1 by Silberschmidt, Daniel, Rodriguez-Mallon, Alina, Mithboakar, Prathiba, Calì, Gaetano, Amendola, Elena, Sanges, Remo, Zannini, Mariastella, Scarfò, Marzia, De Luca, Pasquale, Nitsch, Lucio, Di Lauro, Roberto, De Felice, Mario

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Mapping and Functional Role of Phosphorylation Sites in the Thyroid Transcription Factor-1 (TTF-1) by Zannini, M, Acebron, A, De Felice, M, Arnone, M I, Martin-Pérez, J, Santisteban, P, Di Lauro, R

“…The phosphorylation of thyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor that is required for thyroid-specific expression…”
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Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult by Milenkovic, Milutin, De Deken, Xavier, Jin, Ling, De Felice, Mario, Di Lauro, Roberto, Dumont, Jacques E, Corvilain, Bernard, Miot, Francoise

“…In the thyroid, H2O2 is produced at the apical pole of thyrocytes by one or two NADPH oxidases (NOX), Duox1/2 proteins. The onset of Duox expression was…”
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The Paired-Domain Transcription Factor Pax8 Binds to the Upstream Enhancer of the Rat Sodium/Iodide Symporter Gene and Participates in Both Thyroid-Specific and Cyclic-AMP-Dependent Transcription by Ohno, Makoto, Zannini, Mariastella, Levy, Orlie, Carrasco, Nancy, di Lauro, Roberto

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Paired Domain-containing Factor Pax8 and the Homeodomain-containing Factor TTF-1 Directly Interact and Synergistically Activate Transcription by Di Palma, Tina, Nitsch, Roberto, Mascia, Anna, Nitsch, Lucio, Di Lauro, Roberto, Zannini, Mariastella

“…Pax genes encode for transcription factors essential for tissue development in many species. Pax8, the only member of the family expressed in the thyroid…”
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In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1 by Silberschmidt, Daniel, Rodriguez-Mallon, Alina, Mithboakar, Prathiba, Calì, Gaetano, Amendola, Elena, Sanges, Remo, Zannini, Mariastella, Scarfò, Marzia, De Luca, Pasquale, Nitsch, Lucio, Di Lauro, Roberto, De Felice, Mario

“…The transcription factor Nkx2-1 (also known as TTF-1, Titf1 or T/EBP) contains two apparently redundant activation domains and is post-translationally modified…”
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Immediate early genes induced by H-Ras in thyroid cells by COBELLIS, Gilda, MISSERO, Caterina, SIMIONATI, Barbara, VALLE, Giorgio, DI LAURO, Roberto

“…Expression of oncogenic v-H-Ras in the thyroid cell line FRTL-5 (FRTL-5(Ras)) results in uncontrolled proliferation, loss of thyroid-specific gene expression…”
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PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis by Macchia, Paolo Emidio, Lapi, Paola, Krude, Heiko, Pirro, Maria Teresa, Missero, Caterina, Chiovato, Luca, Souabni, Abdallah, Baserga, Mariangiola, Tassi, Vittorio, Pinchera, Aldo, Fenzi, Gianfranco, Grüters, Annette, Busslinger, Meinrad, Lauro, Roberto Di

“…Permanent congenital hypothyroidism (CH) is a common disease that occurs in 1 of 3,000-4,000 newborns. Except in rare cases due to hypothalamic or pituitary…”
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A physiological mechanism to regulate d-aspartic acid and NMDA levels in mammals revealed by d-aspartate oxidase deficient mice by Errico, Francesco, Pirro, Maria Teresa, Affuso, Andrea, Spinelli, Patrizia, De Felice, Mario, D'Aniello, Antimo, Di Lauro, Roberto

“…Free d-aspartic acid and NMDA are present in the mammalian central nervous system and endocrine glands at significant concentrations, but their physiological…”
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Essential Roles for Fe65, Alzheimer Amyloid Precursor-binding Protein, in the Cellular Response to DNA Damage by Minopoli, Giuseppina, Stante, Maria, Napolitano, Francesco, Telese, Francesca, Aloia, Luigi, De Felice, Mario, Di Lauro, Roberto, Pacelli, Roberto, Brunetti, Arturo, Zambrano, Nicola, Russo, Tommaso

“…Fe65 interacts with the cytosolic domain of the Alzheimer amyloid precursor protein (APP). The functions of the Fe65 are still unknown. To address this point…”
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