Search Results - "Laurita, Kenneth R"

Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart by CUTLER, Michael J, XIAOPING WAN, PLUMMER, Bradley N, HAIYAN LIU, DESCHENES, Isabelle, LAURITA, Kenneth R, HAJJAR, Roger J, ROSENBAUM, David S

“…Recently, we reported that sarcoplasmic reticulum Ca(2+) ATPase 2a (SERCA2a), the pump responsible for reuptake of cytosolic calcium during diastole, plays a…”
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Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine by Zhao, Xiaowei, Ziv, Ohad, Mohammadpour, Reza, Crosby, Benjamin, Hoyt, Walter J., Jenkins, Michael W., Snyder, Christopher, Hendon, Christine, Laurita, Kenneth R., Rollins, Andrew M.

“…Radiofrequency ablation (RFA) is commonly used to treat atrial fibrillation (AF). However, the outcome is often compromised due to the lack of direct real-time…”
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Ventricular arrhythmias in mouse models of diabetic kidney disease by Laurita, Kenneth R., Khan, Shenaz, McMahon, Tracy, Dennis, Adrienne T., Li, Vincent, Gaivin, Robert, Sapa, Hima, Fu, Ji-dong, Schelling, Jeffrey R.

“…Chronic kidney disease (CKD) affects more than 20 million people in the US, and it is associated with a significantly increased risk of sudden cardiac death…”
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An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes by McPheeters, Matthew T, Wang, Yves T, Werdich, Andreas A, Jenkins, Michael W, Laurita, Kenneth R

“…Human cardiac myocytes derived from pluripotent stem cells (hCM) have invigorated interest in genetic disease mechanisms and cardiac safety testing; however,…”
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Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4 by Sun, Qi-An, Hess, Douglas T, Nogueira, Leonardo, Yong, Sandro, Bowles, Dawn E, Eu, Jerry, Laurita, Kenneth R, Meissner, Gerhard, Stamler, Jonathan S

“…Physiological sensing of O2 tension (partial O2 pressure, pO2) plays an important role in some mammalian cellular systems, but striated muscle generally is not…”
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Author Correction: Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine by Zhao, Xiaowei, Ziv, Ohad, Mohammadpour, Reza, Crosby, Benjamin, Hoyt, Walter J., Jenkins, Michael W., Snyder, Christopher, Hendon, Christine, Laurita, Kenneth R., Rollins, Andrew M.

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Cellular mechanisms of arrhythmogenic cardiac alternans by Laurita, Kenneth R., Rosenbaum, David S.

“…Despite the strong association between mechanical dysfunction of the heart and sudden death due to arrhythmias, the causal relationship is not well understood…”
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Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death by Belevych, Andriy E., Terentyev, Dmitry, Viatchenko-Karpinski, Serge, Terentyeva, Radmila, Sridhar, Arun, Nishijima, Yoshinori, Wilson, Lance D., Cardounel, Arturo J., Laurita, Kenneth R., Carnes, Cynthia A., Billman, George E., Gyorke, Sandor

“…Aims Although cardiac alternans is a known predictor of lethal arrhythmias, its underlying causes remain largely undefined in disease settings. The potential…”
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KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity by Nassal, Drew M, Wan, Xiaoping, Liu, Haiyan, Laurita, Kenneth R, Deschênes, Isabelle

“…Pathologic electrical remodeling and attenuated cardiac contractility are featured characteristics of heart failure. Coinciding with these remodeling events is…”
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Arrhythmogenic Delayed Afterdepolarizations Are Promoted by Severe Hypothermia But Not Therapeutic Hypothermia by Fukaya, Hidehira, Piktel, Joseph S., Wan, Xiaoping, Plummer, Bradley N., Laurita, Kenneth R., Wilson, Lance D.

“…Background:Severe hypothermia (SH) is known to be arrhythmogenic, but the effect of therapeutic hypothermia (TH) on arrhythmias is unclear. It is hypothesized…”
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Targeted SERCA2a Gene Expression Identifies Molecular Mechanism and Therapeutic Target for Arrhythmogenic Cardiac Alternans by Cutler, Michael J, Wan, Xiaoping, Laurita, Kenneth R, Hajjar, Roger J, Rosenbaum, David S

“…BACKGROUND—Beat-to-beat alternans of cellular repolarization is closely linked to ventricular arrhythmias in humans. We hypothesized that sarcoplasmic…”
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S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit by Bektik, Emre, Dennis, Adrienne, Pawlowski, Gary, Zhou, Chen, Maleski, Danielle, Takahashi, Satoru, Laurita, Kenneth R, Deschênes, Isabelle, Fu, Ji-Dong

“…Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds a great promise for regenerative medicine and has been studied in several major…”
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Cellular Mechanism of Calcium-Mediated Triggered Activity in the Heart by Katra, Rodolphe P, Laurita, Kenneth R

“…Calcium overload due to enhanced calcium entry is a mechanism for spontaneous calcium release (SCR) from the sarcoplasmic reticulum,…”
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Role of Calcium Cycling Versus Restitution in the Mechanism of Repolarization Alternans by Pruvot, Etienne J, Katra, Rodolphe P, Rosenbaum, David S, Laurita, Kenneth R

“…ABSTRACT—T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action potential duration (APD). The underlying cellular…”
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KChIP2 is a core transcriptional regulator of cardiac excitability by Nassal, Drew M, Wan, Xiaoping, Liu, Haiyan, Maleski, Danielle, Ramirez-Navarro, Angelina, Moravec, Christine S, Ficker, Eckhard, Laurita, Kenneth R, Deschênes, Isabelle

“…Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events,…”
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Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca2+ Triggers by Nassal, Michelle M J, Wan, Xiaoping, Laurita, Kenneth R, Cutler, Michael J

“…Atrial fibrillation (AF) is the most common arrhythmia in humans, yet; treatment has remained sub-optimal due to poor understanding of the underlying…”
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Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart by Cutler, Michael J, Plummer, Bradley N, Wan, Xiaoping, Sun, Qi-An, Hess, Douglas, Liu, Haiyan, Deschenes, Isabelle, Rosenbaum, David S, Stamler, Jonathan S, Laurita, Kenneth R

“…Nitric oxide (NO) derived from the activity of neuronal nitric oxide synthase (NOS1) is involved in S-nitrosylation of key sarcoplasmic reticulum (SR) Ca ²⁺…”
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Effect of Amiodarone and Hypothermia on Arrhythmia Substrates During Resuscitation by Piktel, Joseph S, Suen, Yi, Kouk, Shalen, Maleski, Danielle, Pawlowski, Gary, Laurita, Kenneth R, Wilson, Lance D

“…Background Amiodarone is administered during resuscitation, but its antiarrhythmic effects during targeted temperature management are unknown. The purpose of…”
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Heart failure enhances susceptibility to arrhythmogenic cardiac alternans by Wilson, Lance D., MD, Jeyaraj, Darwin, MD, Wan, Xiaoping, MD, Hoeker, Gregory S., PhD, Said, Tamer H., MD, Gittinger, Matthew, BA, Laurita, Kenneth R., PhD, FHRS, Rosenbaum, David S., MD, FHRS

“…Background Although heart failure (HF) is closely associated with susceptibility to sudden cardiac death (SCD), the mechanisms linking contractile dysfunction…”
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A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1–Induced Activation of Pacemaker Current by Sun, Yu, Timofeyev, Valeriy, Dennis, Adrienne, Bektik, Emre, Wan, Xiaoping, Laurita, Kenneth R., Deschênes, Isabelle, Li, Ronald A., Fu, Ji-Dong

“…The inward rectifier potassium current (I K1 ) is generally thought to suppress cardiac automaticity by hyperpolarizing membrane potential (MP). We recently…”
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