Search Results - "Laurila, Kirsti"

Prediction of disease-related mutations affecting protein localization by Laurila, Kirsti, Vihinen, Mauno

“…Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide…”
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Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood by Salomäki, Henriikka, Vähätalo, Laura H, Laurila, Kirsti, Jäppinen, Norma T, Penttinen, Anna-Maija, Ailanen, Liisa, Ilyasizadeh, Juan, Pesonen, Ullamari, Koulu, Markku

“…The antidiabetic drug metformin is currently used prior and during pregnancy for polycystic ovary syndrome, as well as during gestational diabetes mellitus. We…”
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Genome-wide Profiling of Interleukin-4 and STAT6 Transcription Factor Regulation of Human Th2 Cell Programming by Elo, Laura L., Järvenpää, Henna, Tuomela, Soile, Raghav, Sunil, Ahlfors, Helena, Laurila, Kirsti, Gupta, Bhawna, Lund, Riikka J., Tahvanainen, Johanna, Hawkins, R. David, Orešič, Matej, Lähdesmäki, Harri, Rasool, Omid, Rao, Kanury V., Aittokallio, Tero, Lahesmaa, Riitta

“…Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of…”
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A linear model for transcription factor binding affinity prediction in protein binding microarrays by Annala, Matti, Laurila, Kirsti, Lähdesmäki, Harri, Nykter, Matti

“…Protein binding microarrays (PBM) are a high throughput technology used to characterize protein-DNA binding. The arrays measure a protein's affinity toward…”
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Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis by Thorsen, Kasper, Schepeler, Troels, Øster, Bodil, Rasmussen, Mads H, Vang, Søren, Wang, Kai, Hansen, Kristian Q, Lamy, Philippe, Pedersen, Jakob Skou, Eller, Asger, Mansilla, Francisco, Laurila, Kirsti, Wiuf, Carsten, Laurberg, Søren, Dyrskjøt, Lars, Ørntoft, Torben F, Andersen, Claus L

“…Approximately half of all human genes use alternative transcription start sites (TSSs) to control mRNA levels and broaden the transcriptional output in healthy…”
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Identification of early gene expression changes during human Th17 cell differentiation by Tuomela, Soile, Salo, Verna, Tripathi, Subhash K., Chen, Zhi, Laurila, Kirsti, Gupta, Bhawna, Äijö, Tarmo, Oikari, Lotta, Stockinger, Brigitta, Lähdesmäki, Harri, Lahesmaa, Riitta

“…Th17 cells play an essential role in the pathogenesis of autoimmune and inflammatory diseases. Most of our current understanding on Th17 cell differentiation…”
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Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels by Närvä, Elisa, Pursiheimo, Juha-Pekka, Laiho, Asta, Rahkonen, Nelly, Emani, Maheswara Reddy, Viitala, Miro, Laurila, Kirsti, Sahla, Roosa, Lund, Riikka, Lähdesmäki, Harri, Jaakkola, Panu, Lahesmaa, Riitta

“…Low oxygen tension (hypoxia) contributes critically to pluripotency of human embryonic stem cells (hESCs) by preventing spontaneous differentiation and…”
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A beta-mixture model for dimensionality reduction, sample classification and analysis by Laurila, Kirsti, Oster, Bodil, Andersen, Claus L, Lamy, Philippe, Orntoft, Torben, Yli-Harja, Olli, Wiuf, Carsten

“…Patterns of genome-wide methylation vary between tissue types. For example, cancer tissue shows markedly different patterns from those of normal tissue. In…”
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Correction: Prenatal Metformin Exposure in Mice Programs the Metabolic Phenotype of the Offspring during a High Fat Diet at Adulthood by Salomäki, Henriikka, Vähätalo, Laura H., Laurila, Kirsti, Jäppinen, Norma T., Penttinen, Anna-Maija, Ailanen, Liisa, Ilyasizadeh, Juan, Pesonen, Ullamari, Koulu, Markku

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PROlocalizer: integrated web service for protein subcellular localization prediction by Laurila, Kirsti, Vihinen, Mauno

“…Subcellular localization is an important protein property, which is related to function, interactions and other features. As experimental determination of the…”
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Evaluation of methods for modeling transcription factor sequence specificity by Weirauch, Matthew T, Cote, Atina, Norel, Raquel, Annala, Matti, Zhao, Yue, Riley, Todd R, Saez-Rodriguez, Julio, Cokelaer, Thomas, Vedenko, Anastasia, Talukder, Shaheynoor, Bussemaker, Harmen J, Morris, Quaid D, Bulyk, Martha L, Stolovitzky, Gustavo, Hughes, Timothy R

“…The most comprehensive analysis to date of models of transcription-factor binding specificity reveals the best methods for predicting in vivo binding from in…”
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protein-protein interaction guided method for competitive transcription factor binding improves target predictions by Laurila, Kirsti, Yli-Harja, Olli, Lähdesmäki, Harri

“…An important milestone in revealing cells' functions is to build a comprehensive understanding of transcriptional regulation processes. These processes are…”
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Systematic Analysis of Disease-Related Regulatory Mutation Classes Reveals Distinct Effects on Transcription Factor Binding by Laurila, Kirsti, Lähdesmäki, Harri

“…Detailed knowledge of the mechanisms of transcriptional regulation is essential in understanding the gene expression in its entirety. Transcription is…”
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ESTOOLS Data@Hand: human stem cell gene expression resource by Kong, Lingjia, Aho, Kaisa-Leena, Granberg, Kirsi, Lund, Riikka, Järvenpää, Laura, Seppälä, Janne, Gokhale, Paul, Leinonen, Kalle, Hahne, Lauri, Mäkelä, Jarno, Laurila, Kirsti, Pukkila, Heidi, Närvä, Elisa, Yli-Harja, Olli, Andrews, Peter W, Nykter, Matti, Lahesmaa, Riitta, Roos, Christophe, Autio, Reija

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Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells by Laurila, Kirsti, Autio, Reija, Kong, Lingjia, Närvä, Elisa, Hussein, Samer, Otonkoski, Timo, Lahesmaa, Riitta, Lähdesmäki, Harri

“…Human genomic variations, including single nucleotide polymorphisms (SNPs) and copy number variations (CNVs), are associated with several phenotypic traits…”
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Continuous Hypoxic Culturing of Human Embryonic Stem Cells Enhances SSEA-3 and MYC Levels: e78847 by Naervae, Elisa, Pursiheimo, Juha-Pekka, Laiho, Asta, Rahkonen, Nelly, Emani, Maheswara Reddy, Viitala, Miro, Laurila, Kirsti, Sahla, Roosa, Lund, Riikka, Laehdesmaeki, Harri

“…Low oxygen tension (hypoxia) contributes critically to pluripotency of human embryonic stem cells (hESCs) by preventing spontaneous differentiation and…”
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