Search Results - "Lauri, Eklund"

Therapeutic targeting of the angiopoietin–TIE pathway by Saharinen, Pipsa, Eklund, Lauri, Alitalo, Kari

“…Key Points Angiopoietin ligands (ANG1–ANG4) and the TIE (TIE1 and TIE2) receptor tyrosine kinases form an endothelial signalling pathway that is necessary for…”
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VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling by Heinolainen, Krista, Karaman, Sinem, D’Amico, Gabriela, Tammela, Tuomas, Sormunen, Raija, Eklund, Lauri, Alitalo, Kari, Zarkada, Georgia

“…RATIONALE:Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas…”
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VEGF and angiopoietin signaling in tumor angiogenesis and metastasis by Saharinen, Pipsa, Eklund, Lauri, Pulkki, Kristina, Bono, Petri, Alitalo, Kari

“…Solid tumors require blood vessels for growth and dissemination, and lymphatic vessels as additional conduits for metastatic spread. The identification of…”
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Somatic Activating PIK3CA Mutations Cause Venous Malformation by Limaye, Nisha, Kangas, Jaakko, Mendola, Antonella, Godfraind, Catherine, Schlögel, Matthieu J., Helaers, Raphael, Eklund, Lauri, Boon, Laurence M., Vikkula, Miikka

“…Somatic mutations in TEK, the gene encoding endothelial cell tyrosine kinase receptor TIE2, cause more than half of sporadically occurring unifocal venous…”
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Development of Molecular Therapies for Venous Malformations by Kangas, Jaakko, Nätynki, Marjut, Eklund, Lauri

“…Vascular anomalies are localized defects of morphogenesis that can affect lymphatic and blood vessels. They are generally called birthmarks, typically observed…”
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Endothelial destabilization by angiopoietin-2 via integrin β1 activation by Hakanpaa, Laura, Sipila, Tuomas, Leppanen, Veli-Matti, Gautam, Prson, Nurmi, Harri, Jacquemet, Guillaume, Eklund, Lauri, Ivaska, Johanna, Alitalo, Kari, Saharinen, Pipsa

“…Angiopoietins regulate vascular homeostasis via the endothelial Tie receptor tyrosine kinases. Angiopoietin-1 (Ang1) supports endothelial stabilization via…”
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Mouse models for studying angiogenesis and lymphangiogenesis in cancer by Eklund, Lauri, Bry, Maija, Alitalo, Kari

“…The formation of new blood vessels (angiogenesis) is required for the growth of most tumors. The tumor microenvironment also induces lymphangiogenic factors…”
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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression by Korhonen, Emilia A, Murtomaki, Aino, Jha, Sawan Kumar, Anisimov, Andrey, Pink, Anne, Zhang, Yan, Stritt, Simon, Liaqat, Inam, Stanczuk, Lukas, Alderfer, Laura, Sun, Zhiliang, Kapiainen, Emmi, Singh, Abhishek, Sultan, Ibrahim, Lantta, Anni, Leppanen, Veli-Matti, Eklund, Lauri, He, Yulong, Augustin, Hellmut G, Vaahtomeri, Kari, Saharinen, Pipsa, Makinen, Taija, Alitalo, Kari

“…Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in…”
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VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications by Robciuc, Marius R., Kivelä, Riikka, Williams, Ian M., de Boer, Jan Freark, van Dijk, Theo H., Elamaa, Harri, Tigistu-Sahle, Feven, Molotkov, Dmitry, Leppänen, Veli-Matti, Käkelä, Reijo, Eklund, Lauri, Wasserman, David H., Groen, Albert K., Alitalo, Kari

“…Impaired angiogenesis has been implicated in adipose tissue dysfunction and the development of obesity and associated metabolic disorders. Here, we report the…”
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Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations by Limaye, Nisha, Uebelhoer, Melanie, Wirkkala, Riikka, Vikkula, Miikka, Tuominen, Marjut, Mulliken, John B, Wouters, Vinciane, Boon, Laurence M, Eklund, Lauri

“…Germline substitutions in the endothelial cell tyrosine kinase receptor TIE2 (encoded by TEK) cause a rare, inherited form of venous anomaly known as a…”
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Functional human cell-based vascularised cardiac tissue model for biomedical research and testing by Koivisto, Maria, Tolvanen, Tuomas A., Toimela, Tarja, Miinalainen, Ilkka, Kiviaho, Antti, Kesseli, Juha, Nykter, Matti, Eklund, Lauri, Heinonen, Tuula

“…Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC) are widely used in in vitro biomedical research and testing. However, fully matured,…”
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Common and specific effects of TIE2 mutations causing venous malformations by Nätynki, Marjut, Kangas, Jaakko, Miinalainen, Ilkka, Sormunen, Raija, Pietilä, Riikka, Soblet, Julie, Boon, Laurence M, Vikkula, Miikka, Limaye, Nisha, Eklund, Lauri

“…Venous malformations (VMs) are localized defects in vascular morphogenesis frequently caused by mutations in the gene for the endothelial tyrosine kinase…”
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Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell-Cell Junctions and Lung Metastasis by HOLOPAINEN, Tanja, SAHARINEN, Pipsa, TAMMELA, Tuomas, BENJAMIN, Laura E, YLÄ-HERTTUALA, Seppo, CHING CHING LEOW, GOU YOUNG KOH, ALITALO, Kari, D'AMICO, Gabriela, LAMPINEN, Anita, EKLUND, Lauri, SORMUNEN, Raija, ANISIMOV, Andrey, ZARKADA, Georgia, LOHELA, Marja, HELOTERÄ, Hanna

“…Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it promotes tumor…”
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EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity by Frye, Maike, Stritt, Simon, Ortsäter, Henrik, Hernandez Vasquez, Magda, Kaakinen, Mika, Vicente, Andres, Wiseman, John, Eklund, Lauri, Martínez-Torrecuadrada, Jorge L, Vestweber, Dietmar, Mäkinen, Taija

“…Endothelial integrity is vital for homeostasis and adjusted to tissue demands. Although fluid uptake by lymphatic capillaries is a critical attribute of the…”
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Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner by Richards, Mark, Nwadozi, Emmanuel, Pal, Sagnik, Martinsson, Pernilla, Kaakinen, Mika, Gloger, Marleen, Sjöberg, Elin, Koltowska, Katarzyna, Betsholtz, Christer, Eklund, Lauri, Nordling, Sofia, Claesson-Welsh, Lena

“…Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC) barrier accompanies numerous diseases. The EC barrier is…”
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Angiopoietin-4-dependent venous maturation and fluid drainage in the peripheral retina by Elamaa, Harri, Kihlström, Minna, Kapiainen, Emmi, Kaakinen, Mika, Miinalainen, Ilkka, Ragauskas, Symantas, Cerrada-Gimenez, Marc, Mering, Satu, Nätynki, Marjut, Eklund, Lauri

“…The maintenance of fluid homeostasis is necessary for function of the neural retina; however, little is known about the significance of potential fluid…”
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Synchronous functional magnetic resonance eye imaging, video ophthalmoscopy, and eye surface imaging reveal the human brain and eye pulsation mechanisms by Ebrahimi, Seyed-Mohsen, Tuunanen, Johanna, Saarela, Ville, Honkamo, Marja, Huotari, Niko, Raitamaa, Lauri, Korhonen, Vesa, Helakari, Heta, Järvelä, Matti, Kaakinen, Mika, Eklund, Lauri, Kiviniemi, Vesa

“…The eye possesses a paravascular solute transport pathway that is driven by physiological pulsations, resembling the brain glymphatic pathway. We developed…”
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PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis by Elamaa, Harri, Kaakinen, Mika, Nätynki, Marjut, Szabo, Zoltan, Ronkainen, Veli-Pekka, Äijälä, Ville, Mäki, Joni M., Kerkelä, Risto, Myllyharju, Johanna, Eklund, Lauri

“…Hypoxia plays an important regulatory role in the vasculature to adjust blood flow to meet metabolic requirements. At the level of gene transcription, the…”
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Blood pressure lowering enhances cerebrospinal fluid efflux to the systemic circulation primarily via the lymphatic vasculature by Jukkola, Jari, Kaakinen, Mika, Singh, Abhishek, Moradi, Sadegh, Ferdinando, Hany, Myllylä, Teemu, Kiviniemi, Vesa, Eklund, Lauri

“…Inside the incompressible cranium, the volume of cerebrospinal fluid is directly linked to blood volume: a change in either will induce a compensatory change…”
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VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart by Kivelä, Riikka, Bry, Maija, Robciuc, Marius R, Räsänen, Markus, Taavitsainen, Miia, Silvola, Johanna MU, Saraste, Antti, Hulmi, Juha J, Anisimov, Andrey, Mäyränpää, Mikko I, Lindeman, Jan H, Eklund, Lauri, Hellberg, Sanna, Hlushchuk, Ruslan, Zhuang, Zhen W, Simons, Michael, Djonov, Valentin, Knuuti, Juhani, Mervaala, Eero, Alitalo, Kari

“…Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain‐ and loss‐of function models to elucidate the effects and…”
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