Search Results - "Laurer, Helmut L."

Temporal window of vulnerability to repetitive experimental concussive brain injury by Longhi, Luca, Saatman, Kathryn E, Fujimoto, Scott, Raghupathi, Ramesh, Meaney, David F, Davis, Jason, McMillan B S, Asenia, Conte, Valeria, Laurer, Helmut L, Stein, Sherman, Stocchetti, Nino, McIntosh, Tracy K

“…Repetitive concussive brain injury (CBI) is associated with cognitive alterations and increased risk of neurodegenerative disease. To evaluate the temporal…”
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The duality of the inflammatory response to traumatic brain injury by Lenzlinger, P M, Morganti-Kossmann, M C, Laurer, H L, McIntosh, T K

“…One and a half to two million people sustain a traumatic brain injury (TBI) in the US each year, of which approx 70,000-90,000 will suffer from long-term…”
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Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury by Riess, Peter, Zhang, Chen, Saatman, Kathryn E, Laurer, Helmut L, Longhi, Luca G, Raghupathi, Ramesh, Lenzlinger, Philipp M, Lifshitz, Jonathan, Boockvar, John, Neugebauer, Edmund, Snyder, Evan Y, McIntosh, Tracy K

“…Using the neural stem cell (NSC) clone C17.2, we evaluated the ability of transplanted murine NSCs to attenuate cognitive and neurological motor deficits after…”
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Mild head injury increasing the brain's vulnerability to a second concussive impact by LAURER, Helmut L, BAREYRE, Florence M, MCINTOSH, Tracy K, LEE, Virginia M. Y. C, TROJANOWSKI, John Q, LONGHI, Luca, HOOVER, Rachel, SAATMAN, Kathryn E, RAGHUPATHI, Ramesh, HOSHINO, Shigeru, GRADY, M. Sean

“…Mild, traumatic repetitive head injury (RHI) leads to neurobehavioral impairment and is associated with the early onset of neurodegenerative disease. The…”
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Biphasic elevation in cerebrospinal fluid and plasma concentrations of endothelin 1 after traumatic brain injury in human patients by Maier, Bernd, Lehnert, Mark, Laurer, Helmut L, Marzi, Ingo

“…Severe traumatic brain injury (TBI) is characterized by a high mortality and poor outcome. The pathomechanisms involved are cytokine-mediated proinflammatory…”
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Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma by Maier, Bernd, Lefering, Rolf, Lehnert, Mark, Laurer, Helmut L, Steudel, Wolf I, Neugebauer, Edmund A, Marzi, Ingo

“…Although multiple organ failure (MOF) remains the leading cause of death after trauma, the pathogenic cellular and molecular mechanisms underlying MOF are…”
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Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA by Tomasevic, Gregor, Laurer, Helmut L, Mattiasson, Gustav, van Steeg, Harry, Wieloch, Tadeusz, McIntosh, Tracy K

“…This study investigates the outcome after traumatic brain injury (TBI) in mice lacking the essential DNA repair gene xeroderma pigmentosum group A (XPA). As…”
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Delayed neuromotor recovery and increased memory acquisition dysfunction following experimental brain trauma in mice lacking the DNA repair gene XPA: Laboratory investigation by TOMASEVIC, Gregor, LAURER, Helmut L, MATTIASSON, Gustav, VAN STEEG, Harry, WIELOCH, Tadeusz, MCINTOSH, Tracy K

“…Object This study investigates the outcome after traumatic brain injury (TBI) in mice lacking the essential DNA repair gene xeroderma pigmentosum group A (XPA)…”
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A Review and Rationale for the Use of Genetically Engineered Animals in the Study of Traumatic Brain Injury by Longhi, Luca, Saatman, Kathryn E., Raghupathi, Ramesh, Laurer, Helmut L., Lenzlinger, Philipp M., Riess, Peter, Neugebauer, Edmund, Trojanowski, John Q., Lee, Virginia M.-Y., Grady, M. Sean, Graham, David I., McIntosh, Tracy K.

“…The mechanisms underlying secondary cell death after traumatic brain injury (TBI) are poorly understood. Animal models of TBI recapitulate many clinical and…”
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Outcome after operative treatment of Vancouver type B1 and C periprosthetic femoral fractures: open reduction and internal fixation versus revision arthroplasty by Laurer, Helmut L., Wutzler, Sebastian, Possner, Susann, Geiger, Emanuel V., El Saman, André, Marzi, Ingo, Frank, Johannes

“…Introduction The rate of periprosthetic femoral fractures after hip arthroplasty is rising and the estimated current lifetime incidence is 0.4–2.1%. While most…”
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Periprosthetic humeral fractures after shoulder arthroplasty: operative management and functional outcome by Wutzler, Sebastian, Laurer, Helmut L., Huhnstock, Stefan, Geiger, Emanuel V., Buehren, Volker, Marzi, Ingo

“…Background Currently, little information is available on functional outcome of periprosthetic humeral fractures after shoulder arthroplasty. This investigation…”
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Predictors of pulmonary failure following severe trauma: a trauma registry-based analysis by Geiger, Emanuel V, Lustenberger, Thomas, Wutzler, Sebastian, Lefering, Rolf, Lehnert, Mark, Walcher, Felix, Laurer, Helmut L, Marzi, Ingo

“…The incidence of pulmonary failure in trauma patients is considered to be influenced by several factors such as liver injury. We intended to assess the…”
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Delayed elevation of soluble tumor necrosis factor receptors p75 and p55 in cerebrospinal fluid and plasma after traumatic brain injury by MAIER, Bernd, LEHNERT, Mark, LAURER, Helmut L, MAUTES, Angela E, STEUDEL, Wolf-Ingo, MARZI, Ingo

“…Recent studies have reported a significant inflammatory reaction in the brain and the systemic circulation after traumatic brain injury (TBI). Although there…”
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Prehospital and Early Clinical Care of Infants, Children, and Teenagers Compared to an Adult Cohort: Analysis of 2,961 Children in Comparison to 21,435 Adult Patients from the Trauma Registry of DGU in a 15-Year Period by Wyen, Hendrik, Jakob, Heike, Wutzler, Sebastian, Lefering, Rolf, Laurer, Helmut L., Marzi, Ingo, Lehnert, Mark

“…Background: Although the incidence of pediatric patients in emergency services is as low as 5–10%, trauma remains one of the leading causes of death during…”
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Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice by Huh, Jimmy W, Raghupathi, Ramesh, Laurer, Helmut L, Helfaer, Mark A, Saatman, Kathryn E

“…Microtubule-associated protein 2 (MAP2) is important for microtubule stability and neural plasticity and appears to be among the most vulnerable of the…”
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The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment After Experimental Brain Injury by Cheney, Jessica A., Weisser, Justin D., Bareyre, Florence M., Laurer, Helmut L., Saatman, Kathryn E., Raghupathi, Ramesh, Gribkoff, Valentin, Starrett, John E., McIntosh, Tracy K.

“…Large-conductance, calcium-activated potassium (maxi-K) channels regulate neurotransmitter release and neuronal excitability, and openers of these channels…”
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Fracture and retrosternal dislocation of the medial clavicle in a 12-year-old child—case report, options for diagnosis, and treatment in children by Lehnert, Mark, Maier, Bernd, Jakob, Heike, Maier, Marcus, Laurer, Helmut L., Marzi, Ingo

“…We report a retrosternally displaced epiphysiolysis in a 12-year-old child and discuss options for the most appropriate diagnostic and therapeutic approach. If…”
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Changes in cortical and subcortical energy metabolism after repetitive and single controlled cortical impact injury in the mouse by Manville, Jérôme, Laurer, Helmut L, Steudel, Wolf-Ingo, Mautes, Angelika E M

“…In the present investigation we examined regional ATP, glucose, and lactate content in the cortical and subcortical region, in a mouse model of controlled…”
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Rapid Loss and Partial Recovery of Neurofilament Immunostaining Following Focal Brain Injury in Mice by Huh, Jimmy W., Laurer, Helmut L., Raghupathi, Ramesh, Helfaer, Mark A., Saatman, Kathryn E.

“…Neurofilaments (NF), the intermediate filaments of the neuronal cytoskeleton, provide mechanical stability to the cell. High-molecular-weight NF (NFH)…”
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Transplanted Neural Stem Cells Survive, Differentiate, and Improve Neurological Motor Function after Experimental Traumatic Brain Injury by Riess, Peter, Zhang, Chen, Saatman, Kathryn E., Laurer, Helmut L., Longhi, Luca G., Raghupathi, Ramesh, Lenzlinger, Philipp M., Lifshitz, Jonathan, Boockvar, John, Neugebauer, Edmund, Snyder, Evan Y., McIntosh, Tracy K.

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