Search Results - "Laurent Le Cam"

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53 by Riscal, Romain, Schrepfer, Emilie, Arena, Giuseppe, Cissé, Madi Y., Bellvert, Floriant, Heuillet, Maud, Rambow, Florian, Bonneil, Eric, Sabourdy, Frédérique, Vincent, Charles, Ait-Arsa, Imade, Levade, Thierry, Thibaut, Pierre, Marine, Jean-Christophe, Portais, Jean-Charles, Sarry, Jean-Emmanuel, Le Cam, Laurent, Linares, Laetitia K.

“…The mouse double minute 2 (MDM2) oncoprotein is recognized as a major negative regulator of the p53 tumor suppressor, but growing evidence indicates that its…”
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The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions by Rodier, Geneviève, Kirsh, Olivier, Baraibar, Martín, Houlès, Thibault, Lacroix, Matthieu, Delpech, Hélène, Hatchi, Elodie, Arnould, Stéphanie, Severac, Dany, Dubois, Emeric, Caramel, Julie, Julien, Eric, Friguet, Bertrand, Le Cam, Laurent, Sardet, Claude

“…Recent data support the notion that a group of key transcriptional regulators involved in tumorigenesis, including MYC, p53, E2F1, and BMI1, share an…”
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Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer by Lacroix, Matthieu, Riscal, Romain, Arena, Giuseppe, Linares, Laetitia Karine, Le Cam, Laurent

“…The TP53 gene is one of the most commonly inactivated tumor suppressors in human cancers. p53 functions during cancer progression have been linked to a variety…”
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Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis by Lacroix, Matthieu, Caramel, Julie, Goguet-Rubio, Perrine, Linares, Laetitia K., Estrach, Soline, Hatchi, Elodie, Rodier, Geneviève, Lledo, Gwendaline, de Bettignies, Carine, Thépot, Amélie, Deraison, Céline, Chébli, Karim, Hovnanian, Alain, Hainaut, Pierre, Dubus, Pierre, Sardet, Claude, Le Cam, Laurent, Weinberg, Robert A.

“…A growing body of evidence suggests that the multifunctional protein E4F1 is involved in signaling pathways that play essential roles during normal development…”
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MDM2 controls gene expression independently of p53 in both normal and cancer cells by Arena, Giuseppe, Riscal, Romain, Linares, Laetitia K., Le Cam, Laurent

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The MEK5-ERK5 Kinase Axis Controls Lipid Metabolism in Small-Cell Lung Cancer by Cristea, Sandra, Coles, Garry L, Hornburg, Daniel, Gershkovitz, Maya, Arand, Julia, Cao, Siqi, Sen, Triparna, Williamson, Stuart C, Kim, Jun W, Drainas, Alexandros P, He, Andrew, Cam, Laurent Le, Byers, Lauren Averett, Snyder, Michael P, Contrepois, Kévin, Sage, Julien

“…Small-cell lung cancer (SCLC) is an aggressive form of lung cancer with dismal survival rates. While kinases often play key roles driving tumorigenesis, there…”
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Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia by Stuani, Lucille, Sabatier, Marie, Saland, Estelle, Cognet, Guillaume, Poupin, Nathalie, Bosc, Claudie, Castelli, Florence A, Gales, Lara, Turtoi, Evgenia, Montersino, Camille, Farge, Thomas, Boet, Emeline, Broin, Nicolas, Larrue, Clément, Baran, Natalia, Cissé, Madi Y, Conti, Marc, Loric, Sylvain, Kaoma, Tony, Hucteau, Alexis, Zavoriti, Aliki, Sahal, Ambrine, Mouchel, Pierre-Luc, Gotanègre, Mathilde, Cassan, Cédric, Fernando, Laurent, Wang, Feng, Hosseini, Mohsen, Chu-Van, Emeline, Le Cam, Laurent, Carroll, Martin, Selak, Mary A, Vey, Norbert, Castellano, Rémy, Fenaille, François, Turtoi, Andrei, Cazals, Guillaume, Bories, Pierre, Gibon, Yves, Nicolay, Brandon, Ronseaux, Sébastien, Marszalek, Joseph R, Takahashi, Koichi, DiNardo, Courtney D, Konopleva, Marina, Pancaldi, Véra, Collette, Yves, Bellvert, Floriant, Jourdan, Fabien, Linares, Laetitia K, Récher, Christian, Portais, Jean-Charles, Sarry, Jean-Emmanuel

“…Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells…”
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Numb is required to prevent p53-dependent senescence following skeletal muscle injury by Le Roux, Isabelle, Konge, Julie, Le Cam, Laurent, Flamant, Patricia, Tajbakhsh, Shahragim

“…Regeneration relies on coordinated action of multiple cell types to reconstitute the damaged tissue. Here we inactivate the endocytic adaptor protein Numb in…”
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E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis by Caramel, Julie, Lacroix, Matthieu, Le Cam, Laurent O., Sardet, Claude

“…Comment on: Lacroix M, et al. Proc Natl Acad Sci USA 2010; 107:21076-81…”
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DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks by Rodríguez-Mier, Pablo, Poupin, Nathalie, de Blasio, Carlo, Le Cam, Laurent, Jourdan, Fabien

“…The correct identification of metabolic activity in tissues or cells under different conditions can be extremely elusive due to mechanisms such as…”
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Computational Model of Heterogeneity in Melanoma: Designing Therapies and Predicting Outcomes by Hodgkinson, Arran, Trucu, Dumitru, Lacroix, Matthieu, Le Cam, Laurent, Radulescu, Ovidiu

“…Cutaneous melanoma is a highly invasive tumor and, despite the development of recent therapies, most patients with advanced metastatic melanoma have a poor…”
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The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes by Lacroix, Matthieu, Linares, Laetitia K., Rueda-Rincon, Natalia, Bloch, Katarzyna, Di Michele, Michela, De Blasio, Carlo, Fau, Caroline, Gayte, Laurie, Blanchet, Emilie, Mairal, Aline, Derua, Rita, Cardona, Fernando, Beuzelin, Diane, Annicotte, Jean-Sebastien, Pirot, Nelly, Torro, Adeline, Tinahones, Francisco J., Bernex, Florence, Bertrand-Michel, Justine, Langin, Dominique, Fajas, Lluis, Swinnen, Johannes V., Le Cam, Laurent

“…Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain…”
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Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer by Batnini, Kalil, Houles, Thibault, Kirsh, Olivier, Du Manoir, Stanislas, Zaroual, Mehdi, Delpech, Hélène, Fallet, Chloé, Lacroix, Matthieu, Le Cam, Laurent, Theillet, Charles, Sardet, Claude, Rodier, Geneviève

“…E4F1 is essential for early embryonic mouse development and for controlling the balance between proliferation and survival of actively dividing cells. We…”
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Meeting report of the 4th biennial Metabolism and Cancer symposium by Abdel Hadi, Nadine, Boet, Emeline, Lahalle, Airelle, Lauture, Laura, Refeyton, Alice, Reyes‐Castellanos, Gabriela, Caplet, Nathalie, Carrier, Alice, Le Cam, Laurent, Mazure, Nathalie M., Ricci, Jean‐Ehrland, Rocchi, Stéphane, Sarry, Jean‐Emmanuel, Vasseur, Sophie, Vlaski‐Lafarge, Marija, Rossignol, Rodrigue, Bost, Frédéric

“…The 4th International meeting Metabolism and Cancer initially programed to take place in Bordeaux (France) was held virtually on May 27–29, 2021. The three‐day…”
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E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity by Lacroix, Matthieu, Rodier, Geneviève, Kirsh, Olivier, Houles, Thibault, Delpech, Hélène, Seyran, Berfin, Gayte, Laurie, Casas, Francois, Pessemesse, Laurence, Heuillet, Maud, Bellvert, Floriant, Portais, Jean-Charles, Berthet, Charlene, Bernex, Florence, Brivet, Michele, Boutron, Audrey, Le Cam, Laurent, Sardet, Claude

“…The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic acid…”
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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis by Goguet-Rubio, Perrine, Seyran, Berfin, Gayte, Laurie, Bernex, Florence, Sutter, Anne, Delpech, Hélène, Linares, Laetitia Karine, Riscal, Romain, Repond, Cendrine, Rodier, Geneviève, Kirsh, Olivier, Touhami, Jawida, Noel, Jean, Vincent, Charles, Pirot, Nelly, Pavlovic, Guillaume, Herault, Yann, Sitbon, Marc, Pellerin, Luc, Sardet, Claude, Lacroix, Matthieu, Le Cam, Laurent

“…The multifunctional protein E4 transcription factor 1 (E4F1) is an essential regulator of epidermal stem cell (ESC) maintenance. Here, we found that E4F1…”
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Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2 by Coux, Olivier, Lacroix, Matthieu, Benkirane, Monsef, Kiernan, Rosemary, Triboulet, Robinson, Cuvier, Olivier, Le Cam, Laurent, Latreille, Daniel, Chable-Bessia, Christine, Linares, Laëtitia K

“…The p300-CBP-associated factor (PCAF) is a histone acetyltransferase (HAT) involved in the reversible acetylation of various transcriptional regulators,…”
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The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G1 is controlled by a deacetylase- and E2F-associated bipartite repressor element by POLANOWSKA, Jolanta, FABBRIZIO, Eric, LE CAM, Laurent, TROUCHE, Didier, EMILIANI, Stephane, HERRERA, Raphael, SARDET, Claude

“…The expression of cyclin E and that of a few other bona fide cell cycle regulatory genes periodically oscillates every cycle in proliferating cells. Although…”
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High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New “Histo3D” System by Wendling, Olivia, Hentsch, Didier, Jacobs, Hugues, Lemercier, Nicolas, Taubert, Serge, Pertuy, Fabien, Vonesch, Jean-Luc, Sorg, Tania, Di Michele, Michela, Le Cam, Laurent, Rosahl, Thomas, Carballo-Jane, Ester, Liu, Mindy, Mu, James, Mark, Manuel, Herault, Yann

“…3D imaging in animal models, during development or in adults, facilitates the identification of structural morphological changes that cannot be achieved with…”
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E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells by Hatchi, Elodie, Rodier, Geneviève, Sardet, Claude, Le Cam, Laurent

“…The multifunctional E4F1 protein was originally identified as a cellular target of the E1A adenoviral oncoprotein. Although E4F1 is implicated in several key…”
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