Search Results - "Laurent, Christophe V. F. P"
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Multiplicity of enzymatic functions in the CAZy AA3 family
Published in Applied microbiology and biotechnology (01-03-2018)“…The CAZy auxiliary activity family 3 (AA3) comprises enzymes from the glucose-methanol-choline (GMC) family of oxidoreductases, which assist the activity of…”
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Interaction between Cellobiose Dehydrogenase and Lytic Polysaccharide Monooxygenase
Published in Biochemistry (Easton) (05-03-2019)“…Lytic polysaccharide monooxygenases (LPMOs) are ubiquitous oxidoreductases, facilitating the degradation of polymeric carbohydrates in biomass. Cellobiose…”
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Direct Electron-Transfer Anisotropy of a Site-Specifically Immobilized Cellobiose Dehydrogenase
Published in ACS catalysis (02-08-2019)“…To study the direct electron transfer (DET) of the multicofactor enzyme cellobiose dehydrogenase (CDH) in regard to its orientation on an electrode surface, a…”
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Regioselective C4 and C6 Double Oxidation of Cellulose by Lytic Polysaccharide Monooxygenases
Published in ChemSusChem (21-01-2022)“…Lytic polysaccharide monooxygenases (LPMOs) play a key role in enzymatic degradation of hard‐to‐convert polysaccharides, such as chitin and cellulose. It is…”
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5
Graph transformation for enzymatic mechanisms
Published in Bioinformatics (Oxford, England) (12-07-2021)“…Abstract Motivation The design of enzymes is as challenging as it is consequential for making chemical synthesis in medical and industrial applications more…”
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Protein Conformational Change Is Essential for Reductive Activation of Lytic Polysaccharide Monooxygenase by Cellobiose Dehydrogenase
Published in ACS catalysis (01-05-2020)“…Large-scale protein domain dynamics and electron transfer are often associated. However, as protein motions span a broad range of time and length scales, it is…”
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Oxidized Product Profiles of AA9 Lytic Polysaccharide Monooxygenases Depend on the Type of Cellulose
Published in ACS sustainable chemistry & engineering (25-10-2021)“…Lytic polysaccharide monooxygenases (LPMOs) are essential for enzymatic conversion of lignocellulose-rich biomass in the context of biofuels and platform…”
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Configuration of active site segments in lytic polysaccharide monooxygenases steers oxidative xyloglucan degradation
Published in Biotechnology for biofuels (29-05-2020)“…Lytic polysaccharide monooxygenases (LPMOs) are powerful enzymes that oxidatively cleave plant cell wall polysaccharides. LPMOs classified as fungal Auxiliary…”
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Interdomain Linker of the Bioelecrocatalyst Cellobiose Dehydrogenase Governs the Electron Transfer
Published in ACS catalysis (16-06-2023)“…Direct bioelectrocatalysis applied in biosensors, biofuel cells, and bioelectrosynthesis is based on an efficient electron transfer between enzymes and…”
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Influence of Lytic Polysaccharide Monooxygenase Active Site Segments on Activity and Affinity
Published in International journal of molecular sciences (10-12-2019)“…In past years, new lytic polysaccharide monooxygenases (LPMOs) have been discovered as distinct in their substrate specificity. Their unconventional,…”
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AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila
Published in ACS catalysis (07-04-2023)“…Copper-dependent lytic polysaccharide monooxygenases (LPMOs) classified in Auxiliary Activity (AA) families are considered indispensable as synergistic…”
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Chimeric Cellobiose Dehydrogenases Reveal the Function of Cytochrome Domain Mobility for the Electron Transfer to Lytic Polysaccharide Monooxygenase
Published in ACS catalysis (15-01-2021)“…The natural function of cellobiose dehydrogenase (CDH) to donate electrons from its catalytic flavodehydrogenase (DH) domain via its cytochrome (CYT) domain to…”
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13
Redox thermodynamics of B-class dye-decolorizing peroxidases
Published in Journal of inorganic biochemistry (01-10-2019)“…With >5000 annotated genes dye-decolorizing peroxidases (DyPs) represent a heme b peroxidase family of broad functional diversity. Bacterial B-class DyPs are…”
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Representing Catalytic Mechanisms with Rule Composition
Published in Journal of chemical information and modeling (28-11-2022)“…An “imaginary transition structure” overlays the molecular graphs of the educt and product sides of an elementary chemical reaction in a single graph to…”
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Structural Dynamics of Lytic Polysaccharide Monooxygenase during Catalysis
Published in Biomolecules (Basel, Switzerland) (05-02-2020)“…Lytic polysaccharide monooxygenases (LPMOs) are industrially important oxidoreductases employed in lignocellulose saccharification. Using advanced…”
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Automated Inference of Graph Transformation Rules
Published 03-04-2024“…The explosion of data available in life sciences is fueling an increasing demand for expressive models and computational methods. Graph transformation is a…”
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Efficient Modular Graph Transformation Rule Application
Published 12-01-2022“…Graph transformation formalisms have proven to be suitable tools for the modelling of chemical reactions. They are well established in theoretical studies and…”
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Representing catalytic mechanisms with rule composition
Published 12-01-2022“…Reaction mechanisms are often presented as sequences of elementary steps, such as codified by arrow pushing. We propose an approach for representing such…”
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Graph Transformation for Enzymatic Mechanisms
Published 05-02-2021“…Motivation: The design of enzymes is as challenging as it is consequential for making chemical synthesis in medical and industrial applications more efficient,…”
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