Search Results - "Laurence F. Morton"

Identification in Collagen Type I of an Integrin α2β1-binding Site Containing an Essential GER Sequence by Knight, C. Graham, Morton, Laurence F., Onley, David J., Peachey, Anthony R., Messent, Anthea J., Smethurst, Peter A., Tuckwell, Danny S., Farndale, Richard W., Barnes, Michael J.

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Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue by Saklatvala, J, Rawlinson, L, Waller, R J, Sarsfield, S, Lee, J C, Morton, L F, Barnes, M J, Farndale, R W

“…p38 mitogen-activated protein kinase (MAPK) was identified in platelets on the basis of ( a ) its reactivity with antibodies to C-terminal and N-terminal…”
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The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens by Knight, C. Graham, Morton, Laurence F., Peachey, Anthony R., Tuckwell, Danny S., Farndale, Richard W., Barnes, Michael J.

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Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen by Knight, C G, Morton, L F, Onley, D J, Peachey, A R, Ichinohe, T, Okuma, M, Farndale, R W, Barnes, M J

“…Peptides consisting of a repeat Gly-Pro-Hyp sequence are potent platelet agonists. The aim of this study was: (1) to examine the specificity of this sequence…”
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A collagen-like peptide stimulates tyrosine phosphorylation of syk and phospholipase Cγ2 in platelets independent of the integrin α2β1 by ASSELIN, J, GIBBINS, J. M, ACHISON, M, YOUNG HAN LEE, MORTON, L. F, FARNDALE, R. W, BARNES, M. J, WATSON, S. P

“…Activation of platelets by collagen is mediated through a tyrosine kinase-dependent pathway that is associated with phosphorylation of the Fc receptor γ chain,…”
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Simple Collagen-Like Peptides Support Platelet Adhesion Under Static But Not Under Flow Conditions: Interaction Via α2β1 and von Willebrand Factor With Specific Sequences in Native Collagen Is a Requirement to Resist Shear Forces by Verkleij, Marilyn W., Morton, Laurence F., Knight, C. Graham, de Groot, Philip G., Barnes, Michael J., Sixma, Jan J.

“…The aim of this study was to define the need for specific collagen sequences and the role of their conformation in platelet adhesion to collagen under both…”
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The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens by C. Graham Knight, Laurence F. Morton, Anthony R. Peachey, Danny S. Tuckwell, Richard W. Farndale, Michael J. Barnes

“…We have previously assigned an integrin α 2 β 1 -recognition site in collagen I to the sequence, GFOGERGVEGPOGPA (O = Hyp), corresponding to residues…”
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The Platelet Reactivity of Synthetic Peptides Based on the Collagen III Fragment α1(III)CB4 by Laurence F. Morton, Anthony R. Peachey, C. Graham Knight, Richard W. Farndale, Michael J. Barnes

“…The platelet-reactive collagen III-derived fragment α1(III)CB4 has been synthesized as seven overlapping peptides, each as a homotrimeric triple-helical…”
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The Platelet Reactivity of Synthetic Peptides Based on the Collagen III Fragment α1(III)CB4 by Morton, Laurence F., Peachey, Anthony R., Knight, C. Graham, Farndale, Richard W., Barnes, Michael J.

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Identification in Collagen Type I of an Integrin α2β1-binding Site Containing an Essential GER Sequence by C. Graham Knight, Laurence F. Morton, David J. Onley, Anthony R. Peachey, Anthea J. Messent, Peter A. Smethurst, Danny S. Tuckwell, Richard W. Farndale, Michael J. Barnes

“…The collagen type I-derived fragment α 1 (I)CB3 is known to recognize the platelet collagen receptor integrin α 2 β 1 as effectively as the parent collagen,…”
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Simple collagen-like peptides support platelet adhesion under static but not under flow conditions : Interaction via α2β1 and von Willebrand factor with specific sequences in native collagen is a requirement to resist shear forces by VERKLEIJ, M. W, MORTON, L. F, KNIGHT, C. G, DE GROOT, P. G, BARNES, M. J, SIXMA, J. J

“…The aim of this study was to define the need for specific collagen sequences and the role of their conformation in platelet adhesion to collagen under both…”
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Platelet aggregation by a collagen-like synthetic peptide by Morton, L F, McCulloch, I Y, Barnes, M J

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The platelet reactivity of collagen type VI by Morton, L F, Young, R D, Barnes, M J

“…Collagen type VI in native (undenatured or triple-helical) form has been shown, like collagen types I-V, alpha 1(I) trimer and alpha 2(I) trimer, to possess…”
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