Search Results - "Laurence, Arian"

BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency by Afzali, Behdad, Grönholm, Juha, Vandrovcova, Jana, O'Brien, Charlotte, Sun, Hong-Wei, Vanderleyden, Ine, Davis, Fred P, Khoder, Ahmad, Zhang, Yu, Hegazy, Ahmed N, Villarino, Alejandro V, Palmer, Ira W, Kaufman, Joshua, Watts, Norman R, Kazemian, Majid, Kamenyeva, Olena, Keith, Julia, Sayed, Anwar, Kasperaviciute, Dalia, Mueller, Michael, Hughes, Jason D, Fuss, Ivan J, Sadiyah, Mohammed F, Montgomery-Recht, Kim, McElwee, Joshua, Restifo, Nicholas P, Strober, Warren, Linterman, Michelle A, Wingfield, Paul T, Uhlig, Holm H, Roychoudhuri, Rahul, Aitman, Timothy J, Kelleher, Peter, Lenardo, Michael J, O'Shea, John J, Cooper, Nichola, Laurence, Arian D J

“…BACH2 is required for lymphocyte differentiation. Afzali et al . describe mutations that cause BACH2 disruption, immunodeficiency and autoinflammatory disease…”
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Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells by Mallett, Grace, Laurence, Arian, Amarnath, Shoba

“…Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or…”
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The Human GP130 Cytokine Receptor and Its Expression—an Atlas and Functional Taxonomy of Genetic Variants by Chen, Yin-Huai, van Zon, Sarah, Adams, Alex, Schmidt-Arras, Dirk, Laurence, Arian D. J., Uhlig, Holm H.

“…Genetic variants in IL6ST encoding the shared cytokine receptor for the IL-6 cytokine family GP130 have been associated with a diverse number of clinical…”
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The Role of PTEN in Innate and Adaptive Immunity by Taylor, Henry, Laurence, Arian D J, Uhlig, Holm H

“…The lipid and protein phosphatase and tensin homolog (PTEN) controls the differentiation and activation of multiple immune cells. PTEN acts downstream from T-…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Janus kinases in immune cell signaling by Ghoreschi, Kamran, Laurence, Arian, O'Shea, John J

“…The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non-receptor protein tyrosine kinases. They are involved in cell growth,…”
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Selectivity, efficacy and safety of JAKinibs: new evidence for a still evolving story by Bonelli, Michael, Kerschbaumer, Andreas, Kastrati, Kastriot, Ghoreschi, Kamran, Gadina, Massimo, Heinz, Leonhard X, Smolen, Josef S, Aletaha, Daniel, O'Shea, John, Laurence, Arian

“…Fundamental insight gained over the last decades led to the discovery of cytokines as pivotal drivers of inflammatory diseases such as rheumatoid arthritis,…”
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Translational and clinical advances in JAK‐STAT biology: The present and future of jakinibs by Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.

“…In this era, it is axiomatic that cytokines have critical roles in cellular development and differentiation, immune homeostasis, and host defense. Equally,…”
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TH-17 differentiation: of mice and men by Laurence, Arian, O'Shea, John J

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Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease by Kontzias, Apostolos, Kotlyar, Alexander, Laurence, Arian, Changelian, Paul, O'Shea, John J

“…Highlights ► Cytokines are critical contributors to autoimmune disease, cancer, and other diseases. ► Janus kinases (Jaks) selectively associate with type I…”
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Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells by Chauss, Daniel, Freiwald, Tilo, McGregor, Reuben, Yan, Bingyu, Wang, Luopin, Nova-Lamperti, Estefania, Kumar, Dhaneshwar, Zhang, Zonghao, Teague, Heather, West, Erin E., Vannella, Kevin M., Ramos-Benitez, Marcos J., Bibby, Jack, Kelly, Audrey, Malik, Amna, Freeman, Alexandra F., Schwartz, Daniella M., Portilla, Didier, Chertow, Daniel S., John, Susan, Lavender, Paul, Kemper, Claudia, Lombardi, Giovanna, Mehta, Nehal N., Cooper, Nichola, Lionakis, Michail S., Laurence, Arian, Kazemian, Majid, Afzali, Behdad

“…The molecular mechanisms governing orderly shutdown and retraction of CD4 + type 1 helper T (T H 1) cell responses remain poorly understood. Here we show that…”
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Selective Regulatory Function of Socs3 in the Formation of IL-17-Secreting T Cells by Chen, Zhi, Laurence, Arian, Kanno, Yuka, Pacher-Zavisin, Margit, Zhu, Bing-Mei, Tato, Cristina, Yoshimura, Akihiko, Hennighausen, Lothar, O'Shea, John J.

“…Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency of Socs3…”
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Inborn errors of IL-6 family cytokine responses by Chen, Yin-Huai, Spencer, Sarah, Laurence, Arian, Thaventhiran, James ED, Uhlig, Holm H

“…The IL-6 family of cytokines mediates functions in host protective immunity, development of multiple organs, tissue regeneration and metabolism. Inborn errors…”
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Effect of Huaier granule on recurrence after curative resection of HCC: a multicentre, randomised clinical trial by Chen, Qian, Shu, Chang, Laurence, Arian D, Chen, Yan, Peng, Bao-Gang, Zhen, Zuo-Jun, Cai, Jian-Qiang, Ding, Yi-Tao, Li, Le-Qun, Zhang, Yu-Bao, Zheng, Qi-Chang, Xu, Ge-Liang, Li, Bo, Zhou, Wei-Ping, Cai, Shou-Wang, Wang, Xi-Yan, Wen, Hao, Peng, Xin-Yu, Zhang, Xue-Wen, Dai, Chao-Liu, Bie, Ping, Xing, Bao-Cai, Fu, Zhi-Ren, Liu, Lian-Xin, Mu, Yi, Zhang, Ling, Zhang, Qi-Shun, Jiang, Bin, Qian, Hai-Xin, Wang, Yi-Jun, Liu, Jing-Feng, Qin, Xi-Hu, Li, Qiang, Yin, Ping, Zhang, Zhi-Wei, Chen, Xiao-Ping

“…There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or…”
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Retinoic Acid Receptor Alpha Represses a Th9 Transcriptional and Epigenomic Program to Reduce Allergic Pathology by Schwartz, Daniella M., Farley, Taylor K., Richoz, Nathan, Yao, Chen, Shih, Han-Yu, Petermann, Franziska, Zhang, Yuan, Sun, Hong-Wei, Hayes, Erika, Mikami, Yohei, Jiang, Kan, Davis, Fred P., Kanno, Yuka, Milner, Joshua D., Siegel, Richard, Laurence, Arian, Meylan, Françoise, O’Shea, John J.

“…CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to…”
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TIF1γ and SMAD4 regulation in colorectal cancer: impact on cell proliferation and liver metastasis by Wu, Yanhui, Yu, Bin, Ai, Xi, Zhang, Wei, Chen, Weixun, Laurence, Arian, Zhang, Mingzhi, Chen, Qian, Shao, Yajie, Zhang, Bixiang

“…We investigated the effects of transcriptional intermediary factor 1γ (TIF1γ) and SMAD4 on the proliferation and liver metastasis of colorectal cancer (CRC)…”
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IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner by Wei, Lai, Laurence, Arian, Elias, Kevin M., O'Shea, John J.

“…CD4+ helper T cells can differentiate into several possible fates including: Th1, Th2, T regulatory, and Th17 cells. Although, cytokine production by non-T…”
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PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells by Stathopoulou, Chaido, Gangaplara, Arunakumar, Mallett, Grace, Flomerfelt, Francis A., Liniany, Lukasz P., Knight, David, Samsel, Leigh A., Berlinguer-Palmini, Rolando, Yim, Joshua J., Felizardo, Tania C., Eckhaus, Michael A., Edgington-Mitchell, Laura, Martinez-Fabregas, Jonathan, Zhu, Jinfang, Fowler, Daniel H., van Kasteren, Sander I., Laurence, Arian, Bogyo, Matthew, Watts, Colin, Shevach, Ethan M., Amarnath, Shoba

“…CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic…”
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Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation by Bigley, Venetia, Maisuria, Sheetal, Cytlak, Urszula, Jardine, Laura, Care, Matthew A., Green, Kile, Gunawan, Merry, Milne, Paul, Dickinson, Rachel, Wiscombe, Sarah, Parry, David, Doffinger, Rainer, Laurence, Arian, Fonseca, Claudia, Stoevesandt, Oda, Gennery, Andrew, Cant, Andrew, Tooze, Reuben, Simpson, A. John, Hambleton, Sophie, Savic, Sinisa, Doody, Gina, Collin, Matthew

“…The homozygous K108E mutation of interferon regulatory factor 8 (IRF8) is reported to cause dendritic cell (DC) and monocyte deficiency. However, more…”
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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 by Laurence, Arian, Yang, Xiang-Ping, Ghoreschi, Kamran, Steward-Tharp, Scott M, Rodriguez-Canales, Jaime, Zhu, Jinfang, Grainger, John R, Hirahara, Kiyoshi, Sun, Hong-Wei, Wei, Lai, Vahedi, Golnaz, Kanno, Yuka, O'Shea, John J

“…Loss of IL-2 signaling results in autoimmunity. Laurence and colleagues show that the IL-2–STAT5 axis counteracts STAT3 activation of Il17 to dampen IL-17…”
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