Search Results - "Lauren Hong"

PAM-flexible genome editing with an engineered chimeric Cas9 by Zhao, Lin, Koseki, Sabrina R. T., Silverstein, Rachel A., Amrani, Nadia, Peng, Christina, Kramme, Christian, Savic, Natasha, Pacesa, Martin, Rodríguez, Tomás C., Stan, Teodora, Tysinger, Emma, Hong, Lauren, Yudistyra, Vivian, Ponnapati, Manvitha R., Jacobson, Joseph M., Church, George M., Jakimo, Noah, Truant, Ray, Jinek, Martin, Kleinstiver, Benjamin P., Sontheimer, Erik J., Chatterjee, Pranam

“…CRISPR enzymes require a defined protospacer adjacent motif (PAM) flanking a guide RNA-programmed target site, limiting their sequence accessibility for robust…”
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Development of a blocker of the universal phosphatidylserine- and phosphatidylethanolamine-dependent viral entry pathways by Song, Da-Hoon, Garcia, Gustavo, Situ, Kathy, Chua, Bernadette A., Hong, Madeline Lauren O., Do, Elyza A., Ramirez, Christina M., Harui, Airi, Arumugaswami, Vaithilingaraja, Morizono, Kouki

“…Envelope phosphatidylserine (PtdSer) and phosphatidylethanolamine (PtdEtr) have been shown to mediate binding of enveloped viruses. However, commonly used…”
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Catheter ablation for the management of atrial fibrillation: current technical perspectives by Hong, Kathryn Lauren, Borges, Jazlyn, Glover, Benedict

“…Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, with a prevalence that increases alongside the ageing population…”
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High-resolution mapping of the atria using the HD Grid catheter by Hong, Kathryn Lauren, Redfearn, Damien, Chacko, Sanoj, Baley, Jason, Baranchuk, Adrian, Glover, Benedict Martin

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The effects of poly(ethylene glycol) grafting density on the extensional solution flows of high molecular weight polyacrylamide by Linscott, Adam, Zhu, Rene, Hong, Lauren, Castellanos, Madison, Morozova, Svetlana

“…Controlling the extensional rheological properties of solutions is of great interest for a number of applications, such as printing and coatings, as polymeric…”
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Generative design of therapeutics that bind and modulate protein states by Chen, Tianlai, Hong, Lauren, Yudistyra, Vivian, Vincoff, Sophia, Chatterjee, Pranam

“…Numerous therapeutic approaches have been developed to enable interrogation and modulation of protein isoforms, but often require laborious experimental…”
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B-PO05-078 THE NOVEL USE OF OMNIPOLAR ELECTROGRAMS TO PERFORM VOLTAGE MAPPING IN PATIENTS UNDERGOING CATHETER ABLATION FOR ATRIAL FIBRILLATION by Glover, Benedict M., Massé, Stéphane, Nanthakumar, Kumaraswamy, Jiang, Yidi, Malaweera, Anura, Korogyi, Adam, Deno, D. Curtis, Lauren Hong, Kathryn

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PETA: Parameter-Efficient Trojan Attacks by Hong, Lauren, Wang, Ting

“…Parameter-efficient fine-tuning (PEFT) enables efficient adaptation of pre-trained language models (PLMs) to specific tasks. By tuning only a minimal set of…”
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Cannabis and Driving in Older Adults by Di Ciano, Patricia, Rajji, Tarek K, Hong, Lauren, Zhao, Sampson, Byrne, Patrick, Elzohairy, Yoassry, Brubacher, Jeffrey R, McGrath, Michael, Brands, Bruna, Chen, Sheng, Wang, Wei, Hasan, Omer S M, Wickens, Christine M, Kaduri, Pamela, Le Foll, Bernard

“…Epidemiological studies have found that cannabis increases the risk of a motor vehicle collision. Cannabis use is increasing in older adults, but laboratory…”
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SaLT&PepPr is an interface-predicting language model for designing peptide-guided protein degraders by Brixi, Garyk, Ye, Tianzheng, Hong, Lauren, Wang, Tian, Monticello, Connor, Lopez-Barbosa, Natalia, Vincoff, Sophia, Yudistyra, Vivian, Zhao, Lin, Haarer, Elena, Chen, Tianlai, Pertsemlidis, Sarah, Palepu, Kalyan, Bhat, Suhaas, Christopher, Jayani, Li, Xinning, Liu, Tong, Zhang, Sue, Petersen, Lillian, DeLisa, Matthew P., Chatterjee, Pranam

“…Protein-protein interactions (PPIs) are critical for biological processes and predicting the sites of these interactions is useful for both computational and…”
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SaLT PepPr is an interface-predicting language model for designing peptide-guided protein degraders by Garyk Brixi, Tianzheng Ye, Lauren Hong, Tian Wang, Connor Monticello, Natalia Lopez-Barbosa, Sophia Vincoff, Vivian Yudistyra, Lin Zhao, Elena Haarer, Tianlai Chen, Sarah Pertsemlidis, Kalyan Palepu, Suhaas Bhat, Jayani Christopher, Xinning Li, Tong Liu, Sue Zhang, Lillian Petersen, Matthew P. DeLisa, Pranam Chatterjee

“…Abstract Protein-protein interactions (PPIs) are critical for biological processes and predicting the sites of these interactions is useful for both…”
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B-PO03-029 CONVENTIONAL ABLATION WITH HALF NORMAL SALINE IS EQUIVALENT TO HIGH POWER SHORT DURATION ABLATION WITH NORMAL SALINE by Glover, Benedict M., Malaweera, Anura, Hong, Kathryn Lauren, Lee, Thea, Huang, Grace, Park, Joy Sumin, Sanhueza, Eduardo, Terricabras, Maria

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Monitoring and Adapting ML Models on Mobile Devices by Hao, Wei, Wang, Zixi, Hong, Lauren, Li, Lingxiao, Karayanni, Nader, Mao, Chengzhi, Yang, Junfeng, Cidon, Asaf

“…ML models are increasingly being pushed to mobile devices, for low-latency inference and offline operation. However, once the models are deployed, it is hard…”
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ToolLLM: Facilitating Large Language Models to Master 16000+ Real-world APIs by Qin, Yujia, Liang, Shihao, Ye, Yining, Zhu, Kunlun, Yan, Lan, Lu, Yaxi, Lin, Yankai, Cong, Xin, Tang, Xiangru, Qian, Bill, Zhao, Sihan, Hong, Lauren, Tian, Runchu, Xie, Ruobing, Zhou, Jie, Gerstein, Mark, Li, Dahai, Liu, Zhiyuan, Sun, Maosong

“…Despite the advancements of open-source large language models (LLMs), e.g., LLaMA, they remain significantly limited in tool-use capabilities, i.e., using…”
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PepMLM: Target Sequence-Conditioned Generation of Therapeutic Peptide Binders via Span Masked Language Modeling by Chen, Tianlai, Dumas, Madeleine, Watson, Rio, Vincoff, Sophia, Peng, Christina, Zhao, Lin, Hong, Lauren, Pertsemlidis, Sarah, Shaepers-Cheu, Mayumi, Wang, Tian Zi, Srijay, Divya, Monticello, Connor, Vure, Pranay, Pulugurta, Rishab, Kholina, Kseniia, Goel, Shrey, DeLisa, Matthew P, Truant, Ray, Aguilar, Hector C, Chatterjee, Pranam

“…Target proteins that lack accessible binding pockets and conformational stability have posed increasing challenges for drug development. Induced proximity…”
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Catheter Ablation of Symptomatic Atrial Fibrillation: Impact on Physical Activity, Health-related Quality of Life, and Burden of Arrhythmia by Hong, Kathryn Lauren

“…Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting more than 33 million individuals worldwide. AF may lead to severe…”
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Canada-wide mixed methods analysis evaluating the reasons for inappropriate emergency department presentation in patients with a history of atrial fibrillation: the multicentre AF-ED trial by Hong, Kathryn Lauren, Babiolakis, Corinne, Zile, Brigita, Bullen, Milena, Haseeb, Sohaib, Halperin, Frank, Hohl, Corinne M, Magee, Kirk, Sandhu, Roopinder K, Tian, Simon Yu, Kennedy, Ashley, Lobban, Trudie, Mariano, Zana, Dorian, Paul, Angaran, Paul, Evans, Marilyn, Leong-Sit, Peter, Glover, Benedict M

“…ObjectivesThe primary objective of this study was to ascertain the reasons for emergency department (ED) attendance among patients with a history of atrial…”
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Evolution of occupational choices in young adults from 1960 to 2010 by Hong, Vanessa Lauren

“…Across time, the roles of women and men in the workforce have evolved. Crossing traditional gender barriers in occupational choice has become more commonplace,…”
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High-resolution mapping of the atria using the HD Grid catheter by Hong, Kathryn Lauren, Redfearn, Damien, Chacko, Sanoj, Baley, Jason, Baranchuk, Adrian, Glover, Benedict Martin

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