Search Results - "Launer, J"

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression by van Sloten, Thomas T, Sedaghat, Sanaz, Carnethon, Mercedes R, Launer, Lenore J, Stehouwer, Coen D A

“…Adults with type 2 diabetes are at an increased risk of developing certain brain or mental disorders, including stroke, dementia, and depression. Although…”
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Cerebral small vessel disease and risk of incident stroke, dementia and depression, and all-cause mortality: A systematic review and meta-analysis by Rensma, Sytze P., van Sloten, Thomas T., Launer, Lenore J., Stehouwer, Coen D.A.

“…•Cerebral small vessel disease may lead to stroke, dementia, and depression.•We did a systematic review/meta-analysis of studies on these associations.•Strong…”
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Impact of Hypertension on Cognitive Function: A Scientific Statement From the American Heart Association by Iadecola, Costantino, Yaffe, Kristine, Biller, José, Bratzke, Lisa C, Faraci, Frank M, Gorelick, Philip B, Gulati, Martha, Kamel, Hooman, Knopman, David S, Launer, Lenore J, Saczynski, Jane S, Seshadri, Sudha, Zeki Al Hazzouri, Adina

“…BACKGROUND—Age-related dementia, most commonly caused by Alzheimer disease or cerebrovascular factors (vascular dementia), is a major public health threat…”
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Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan by Pomponio, Raymond, Erus, Guray, Habes, Mohamad, Doshi, Jimit, Srinivasan, Dhivya, Mamourian, Elizabeth, Bashyam, Vishnu, Nasrallah, Ilya M., Satterthwaite, Theodore D., Fan, Yong, Launer, Lenore J., Masters, Colin L., Maruff, Paul, Zhuo, Chuanjun, Völzke, Henry, Johnson, Sterling C., Fripp, Jurgen, Koutsouleris, Nikolaos, Wolf, Daniel H., Gur, Raquel, Gur, Ruben, Morris, John, Albert, Marilyn S., Grabe, Hans J., Resnick, Susan M., Bryan, R. Nick, Wolk, David A., Shinohara, Russell T., Shou, Haochang, Davatzikos, Christos

“…As medical imaging enters its information era and presents rapidly increasing needs for big data analytics, robust pooling and harmonization of imaging data…”
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Co-regulatory networks of human serum proteins link genetics to disease by Emilsson, Valur, Ilkov, Marjan, Lamb, John R, Finkel, Nancy, Gudmundsson, Elias F, Pitts, Rebecca, Hoover, Heather, Gudmundsdottir, Valborg, Horman, Shane R, Aspelund, Thor, Shu, Le, Trifonov, Vladimir, Sigurdsson, Sigurdur, Manolescu, Andrei, Zhu, Jun, Olafsson, Örn, Jakobsdottir, Johanna, Lesley, Scott A, To, Jeremy, Zhang, Jia, Harris, Tamara B, Launer, Lenore J, Zhang, Bin, Eiriksdottir, Gudny, Yang, Xia, Orth, Anthony P, Jennings, Lori L, Gudnason, Vilmundur

“…Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end,…”
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A genome-wide association study of serum proteins reveals shared loci with common diseases by Gudjonsson, Alexander, Gudmundsdottir, Valborg, Axelsson, Gisli T., Gudmundsson, Elias F., Jonsson, Brynjolfur G., Launer, Lenore J., Lamb, John R., Jennings, Lori L., Aspelund, Thor, Emilsson, Valur, Gudnason, Vilmundur

“…With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of…”
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MRI signatures of brain age and disease over the lifespan based on a deep brain network and 14 468 individuals worldwide by Bashyam, Vishnu M, Erus, Guray, Doshi, Jimit, Habes, Mohamad, Nasrallah, Ilya, Truelove-Hill, Monica, Srinivasan, Dhivya, Mamourian, Liz, Pomponio, Raymond, Fan, Yong, Launer, Lenore J, Masters, Colin L, Maruff, Paul, Zhuo, Chuanjun, Völzke, Henry, Johnson, Sterling C, Fripp, Jurgen, Koutsouleris, Nikolaos, Satterthwaite, Theodore D, Wolf, Daniel, Gur, Raquel E, Gur, Ruben C, Morris, John, Albert, Marilyn S, Grabe, Hans J, Resnick, Susan, Bryan, R Nick, Wolk, David A, Shou, Haochang, Davatzikos, Christos

“…Deep learning has emerged as a powerful approach to constructing imaging signatures of normal brain ageing as well as of various neuropathological processes…”
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Early Adult to Midlife Cardiovascular Risk Factors and Cognitive Function by Yaffe, Kristine, Vittinghoff, Eric, Pletcher, Mark J, Hoang, Tina D, Launer, Lenore J, Whitmer, Rachel, Coker, Laura H, Sidney, Stephen

“…BACKGROUND—Studies have linked midlife and late-life cardiovascular risk factors (CVRFs) to cognitive function, yet little is known about CVRF exposure in…”
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Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility - Reykjavik Study by Mitchell, Gary F., van Buchem, Mark A., Sigurdsson, Sigurdur, Gotal, John D., Jonsdottir, Maria K., Kjartansson, Ólafur, Garcia, Melissa, Aspelund, Thor, Harris, Tamara B., Gudnason, Vilmundur, Launer, Lenore J.

“…Aortic stiffness increases with age and vascular risk factor exposure and is associated with increased risk for structural and functional abnormalities in the…”
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Smoking mediates the relationship between SES and brain volume: The CARDIA study by Dougherty, Ryan J, Moonen, Justine, Yaffe, Kristine, Sidney, Stephen, Davatzikos, Christos, Habes, Mohamad, Launer, Lenore J

“…Investigate whether socioeconomic status (SES) was related to brain volume in aging related regions, and if so, determine whether this relationship was…”
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Association between arterial stiffness, cerebral small vessel disease and cognitive impairment: A systematic review and meta-analysis by van Sloten, Thomas T, Protogerou, Athanase D, Henry, Ronald M A, Schram, Miranda T, Launer, Lenore J, Stehouwer, Coen D A

“…Arterial stiffness may be a cause of cerebral small vessel disease and cognitive impairment. We therefore performed a systematic review and meta-analysis of…”
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The Honolulu-Asia Aging Study: epidemiologic and neuropathologic research on cognitive impairment by Gelber, Rebecca P, Launer, Lenore J, White, Lon R

“…The Honolulu-Asia Aging Study (HAAS) is a longitudinal epidemiologic investigation of rates, risk factors, and neuropathologic abnormalities associated with…”
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Space and location of cerebral microbleeds, cognitive decline, and dementia in the community by Ding, Jie, Sigurðsson, Sigurður, Jónsson, Pálmi V, Eiriksdottir, Gudny, Meirelles, Osorio, Kjartansson, Olafur, Lopez, Oscar L, van Buchem, Mark A, Gudnason, Vilmundur, Launer, Lenore J

“…OBJECTIVE:To assess the association of the number and anatomic location of cerebral microbleeds (CMBs), visible indicators of microvascular damage on MRI, with…”
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Microinfarcts, brain atrophy, and cognitive function: The Honolulu Asia Aging Study Autopsy Study by Launer, Lenore J., Hughes, Timothy M., White, Lon R.

“…Objective: This study was untaken to investigate the association of micro brain infarcts (MBIs) with antemortem global cognitive function (CF), and whether…”
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The Brain Chart of Aging: Machine‐learning analytics reveals links between brain aging, white matter disease, amyloid burden, and cognition in the iSTAGING consortium of 10,216 harmonized MR scans by Habes, Mohamad, Pomponio, Raymond, Shou, Haochang, Doshi, Jimit, Mamourian, Elizabeth, Erus, Guray, Nasrallah, Ilya, Launer, Lenore J., Rashid, Tanweer, Bilgel, Murat, Fan, Yong, Toledo, Jon B., Yaffe, Kristine, Sotiras, Aristeidis, Srinivasan, Dhivya, Espeland, Mark, Masters, Colin, Maruff, Paul, Fripp, Jurgen, Völzk, Henry, Johnson, Sterling C., Morris, John C., Albert, Marilyn S., Miller, Michael I., Bryan, R. Nick, Grabe, Hans J., Resnick, Susan M., Wolk, David A., Davatzikos, Christos

“…Introduction Relationships between brain atrophy patterns of typical aging and Alzheimer's disease (AD), white matter disease, cognition, and AD neuropathology…”
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Prevalence and prognosis of ischaemic and non-ischaemic myocardial fibrosis in older adults by Shanbhag, Sujata M, Greve, Anders M, Aspelund, Thor, Schelbert, Erik B, Cao, J Jane, Danielsen, Ragnar, þorgeirsson, Guðmundur, Sigurðsson, Sigurður, Eiríksdóttir, Guðný, Harris, Tamara B, Launer, Lenore J, Guðnason, Vilmundur, Arai, Andrew E

“…Abstract Aims Non-ischaemic cardiomyopathies (NICM) can cause heart failure and death. Cardiac magnetic resonance (CMR) detects myocardial scar/fibrosis…”
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Batch effects removal for microbiome data via conditional quantile regression by Ling, Wodan, Lu, Jiuyao, Zhao, Ni, Lulla, Anju, Plantinga, Anna M., Fu, Weijia, Zhang, Angela, Liu, Hongjiao, Song, Hoseung, Li, Zhigang, Chen, Jun, Randolph, Timothy W., Koay, Wei Li A., White, James R., Launer, Lenore J., Fodor, Anthony A., Meyer, Katie A., Wu, Michael C.

“…Batch effects in microbiome data arise from differential processing of specimens and can lead to spurious findings and obscure true signals. Strategies…”
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Heterogeneity in white blood cells has potential to confound DNA methylation measurements by Adalsteinsson, Bjorn T, Gudnason, Haukur, Aspelund, Thor, Harris, Tamara B, Launer, Lenore J, Eiriksdottir, Gudny, Smith, Albert V, Gudnason, Vilmundur

“…Epigenetic studies are commonly conducted on DNA from tissue samples. However, tissues are ensembles of cells that may each have their own epigenetic profile,…”
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Current Developments in Dementia Risk Prediction Modelling: An Updated Systematic Review by Tang, Eugene Y H, Harrison, Stephanie L, Errington, Linda, Gordon, Mark F, Visser, Pieter Jelle, Novak, Gerald, Dufouil, Carole, Brayne, Carol, Robinson, Louise, Launer, Lenore J, Stephan, Blossom C M

“…Accurate identification of individuals at high risk of dementia influences clinical care, inclusion criteria for clinical trials and development of…”
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Sleep Duration and White Matter Quality in Middle-Aged Adults by Yaffe, Kristine, Nasrallah, Ilya, Hoang, Tina D, Lauderdale, Diane S, Knutson, Kristen L, Carnethon, Mercedes R, Launer, Lenore J, Lewis, Cora E, Sidney, Stephen

“…Sleep duration has been associated with risk of dementia and stroke, but few studies have investigated the relationship between sleep duration and brain MRI…”
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