Search Results - "Laughlin, T."

Imaging the glycome by Laughlin, Scott T, Bertozzi, Carolyn R

“…Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are…”
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In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish by Laughlin, Scott T, Baskin, Jeremy M, Amacher, Sharon L, Bertozzi, Carolyn R

“…Glycans are attractive targets for molecular imaging but have been inaccessible because of their incompatibility with genetically encoded reporters. We…”
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Light-Activated Staudinger–Bertozzi Ligation within Living Animals by Shah, Lisa, Laughlin, Scott T, Carrico, Isaac S

“…The ability to regulate small molecule chemistry in vivo will enable new avenues of exploration in imaging and pharmacology. However, realization of these…”
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Copper-free click chemistry for dynamic in vivo imaging by Baskin, Jeremy M, Prescher, Jennifer A, Laughlin, Scott T, Agard, Nicholas J, Chang, Pamela V, Miller, Isaac A, Lo, Anderson, Codelli, Julian A, Bertozzi, Carolyn R

“…Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes…”
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Tuberactinomycin antibiotics: Biosynthesis, anti-mycobacterial action, and mechanisms of resistance by Laughlin, Zane T, Conn, Graeme L

“…The tuberactinomycins are a family of cyclic peptide ribosome-targeting antibiotics with a long history of use as essential second-line treatments for…”
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Caged cyclopropenes for controlling bioorthogonal reactivity by Kumar, Pratik, Jiang, Ting, Li, Sining, Zainul, Omar, Laughlin, Scott T

“…Bioorthogonal ligations have been designed and optimized to provide new experimental avenues for understanding biological systems. Generally, these…”
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Role of interleukin‐6 and endothelin‐1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid by Hakozaki, T., Wang, J., Laughlin, T., Jarrold, B., Zhao, W., Furue, M.

“…Background Hyperpigmented spots are common issues in all ethnicities with a hallmark characteristic of increased melanocyte dendricity. Objectives To determine…”
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The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes by Wang, J., Jarrold, B., Zhao, W., Deng, G., Moulton, L., Laughlin, T., Hakozaki, T.

“…Background Hyperpigmented spots are common issues in all ethnicities, involving multiple intrinsic and extrinsic factors such as UVB exposure, hormone balance,…”
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Visualizing enveloping layer glycans during zebrafish early embryogenesis by Baskin, Jeremy M, Dehnert, Karen W, Laughlin, Scott T, Amacher, Sharon L, Bertozzi, Carolyn R

“…Developmental events can be monitored at the cellular and molecular levels by using noninvasive imaging techniques. Among the biomolecules that might be…”
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Anthropomorphic Characterization of Ankle Joint by Gundapaneni, Dinesh, Tsatalis, James T, Laughlin, Richard T, Goswami, Tarun

“…Even though total ankle replacement has emerged as an alternative treatment to arthrodesis, the long-term clinical results are unsatisfactory. Proper design of…”
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Association Between Diabetes, Obesity, and Short-Term Outcomes Among Patients Surgically Treated for Ankle Fracture by Cavo, Matthew J., MD, Markert, Ronald, PhD, Laughlin, Richard T., MD, Fox, Justin P., MD, MHS

“…Background Although obesity is widely accepted as a risk factor for surgical complications following orthopaedic surgery, the literature is unclear with regard…”
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Recruitment Sources of Channel and Blue Catfishes Inhabiting the Middle Mississippi River by Laughlin, T. W., Whitledge, G. W., Oliver, D. C., Rude, N. P.

“…Insight into environments that contribute recruits to adult fish stocks in riverine systems is vital for effective population management and conservation…”
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A Chemical Reporter Strategy to Probe Glycoprotein Fucosylation by Rabuka, David, Hubbard, Sarah C, Laughlin, Scott T, Argade, Sulabha P, Bertozzi, Carolyn R

“…Fucosylated glycoproteins are involved in many cell−cell recognition events and are markers of embryonic and malignant tissue. Here we report a method for…”
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Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes by Laughlin, T., Tan, Y., Jarrold, B., Chen, J., Li, L., Fang, B., Zhao, W., Tamura, M., Matsubara, A., Deng, G., Wang, X., Hakozaki, T.

“…Background The accumulation of advanced glycation end products (AGEs) can impact cellular homoeostasis and protein structure, thus is implicated in numerous…”
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Morphological and transcriptional evaluation of multiple facial cutaneous hyperpigmented spots by Hakozaki, T., Jarrold, B., Zhao, W., Laughlin, T., Whittenbarger, D., Jewell‐Motz, E. A., Boissy, R. E.

“…Background Morphological characteristics of major facial hyperpigmented spots have been well documented. However, detailed alterations of respective…”
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Metabolic Labeling of Fucosylated Glycans in Developing Zebrafish by Dehnert, Karen W, Beahm, Brendan J, Huynh, Thinh T, Baskin, Jeremy M, Laughlin, Scott T, Wang, Wei, Wu, Peng, Amacher, Sharon L, Bertozzi, Carolyn R

“…Many developmental processes depend on proper fucosylation, but this post-translational modification is difficult to monitor in vivo. Here we applied a…”
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Preliminary Results and a Treatment Algorithm for Osteomyelitis of the Distal Tibia and Talus by Fernandez, Augusto Roca, Smith, Richard M., Bedoya, Federico Palacio, Laughlin, Richard T.

“…Category: Hindfoot; Ankle Introduction/Purpose: Management of hindfoot osteomyelitis involves eradication of infection, deformity correction, and bony…”
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Implementation of a Multidisciplinary Preoperative Protocol for Geriatric Hip Fractures Improves Time to Surgery at a Level III Trauma Center by Meyer, Jacob R., Earnest, Ryan E., Johnson, Brian M., Steffensmeier, Andrew M., Vyas, Dheer A., Laughlin, Richard T.

“…Introduction Hip fractures are common among the elderly, and delays in time to surgery (TTS) and length of stay (LOS) are known to increase mortality risk in…”
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Optimized low pH formulation of niacinamide enhances induction of autophagy marker ATG5 gene expression and protein levels in human epidermal keratinocytes by Oblong, J.E., DeAngelis, Y.M., Jarrold, B.B., Bierman, J.C., Rovito, H.A., Vires, L., Fang, B., Laughlin, T., Zhao, W., Hartman, S.M., Kainkaryam, R., Adams, R., Sherrill, J.D., Hakozaki, T.

“…Background Macromolecules in skin cells are damaged when exposed to environmental stressors, leading to disrupted cellular function and homeostasis. While…”
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Hospital-Based Acute Care After Total Hip and Knee Arthroplasty: Implications for Quality Measurement by Trimba, Roman, MD, Laughlin, Richard T., MD, Krishnamurthy, Anil, MD, Ross, Joseph S., MD, MHS, Fox, Justin P., MD, MHS

“…Abstract Background Although hospital readmissions are being adopted as a quality measure after total hip or knee arthroplasty, they may fail accurately…”
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