Search Results - "Lauffenburger, Douglas A"

Correlates of protection against SARS-CoV-2 in rhesus macaques by McMahan, Katherine, Yu, Jingyou, Mercado, Noe B., Loos, Carolin, Tostanoski, Lisa H., Chandrashekar, Abishek, Liu, Jinyan, Peter, Lauren, Atyeo, Caroline, Zhu, Alex, Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Jacob-Dolan, Catherine, Li, Zhenfeng, Nampanya, Felix, Patel, Shivani, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Yalley-Ogunro, Jake, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Lauffenburger, Douglas A., Alter, Galit, Barouch, Dan H.

“…Recent studies have reported the protective efficacy of both natural 1 and vaccine-induced 2 – 7 immunity against challenge with severe acute respiratory…”
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Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics by Kumar, Manu P., Du, Jinyan, Lagoudas, Georgia, Jiao, Yang, Sawyer, Andrew, Drummond, Daryl C., Lauffenburger, Douglas A., Raue, Andreas

“…Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions (for instance,…”
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Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data by Holland, Christian H, Tanevski, Jovan, Perales-Patón, Javier, Gleixner, Jan, Kumar, Manu P, Mereu, Elisabetta, Joughin, Brian A, Stegle, Oliver, Lauffenburger, Douglas A, Heyn, Holger, Szalai, Bence, Saez-Rodriguez, Julio

“…Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell…”
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Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer by Miller, Miles A, Sullivan, Ryan J, Lauffenburger, Douglas A

“…Proteases known as sheddases cleave the extracellular domains of their substrates from the cell surface. The A Disintegrin and Metalloproteinases ADAM10 and…”
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Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation by Tape, Christopher J., Ling, Stephanie, Dimitriadi, Maria, McMahon, Kelly M., Worboys, Jonathan D., Leong, Hui Sun, Norrie, Ida C., Miller, Crispin J., Poulogiannis, George, Lauffenburger, Douglas A., Jørgensen, Claus

“…Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRASG12D) also regulates tumor…”
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Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition by Stopfer, Lauren E., Mesfin, Joshua M., Joughin, Brian A., Lauffenburger, Douglas A., White, Forest M.

“…Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an antitumor immune response…”
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Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility by Jørgensen, Hilde, M.D, Hill, Abby S., B.S, Beste, Michael T., Ph.D, Kumar, Manu P., B.S, Chiswick, Evan, Ph.D, Fedorcsak, Peter, M.D., Ph.D, Isaacson, Keith B., M.D, Lauffenburger, Douglas A., Ph.D, Griffith, Linda G., Ph.D, Qvigstad, Erik, M.D., Ph.D

“…Objective Our aim was to characterize peritoneal cytokine profiles in patients with infertility, with and without endometriosis, to illuminate potential…”
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Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology by Chung, Amy W., Kumar, Manu P., Arnold, Kelly B., Yu, Wen Han, Schoen, Matthew K., Dunphy, Laura J., Suscovich, Todd J., Frahm, Nicole, Linde, Caitlyn, Mahan, Alison E., Hoffner, Michelle, Streeck, Hendrik, Ackerman, Margaret E., McElrath, M. Juliana, Schuitemaker, Hanneke, Pau, Maria G., Baden, Lindsey R., Kim, Jerome H., Michael, Nelson L., Barouch, Dan H., Lauffenburger, Douglas A., Alter, Galit

“…While antibody titers and neutralization are considered the gold standard for the selection of successful vaccines, these parameters are often inadequate…”
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Intratumor heterogeneity alters most effective drugs in designed combinations by Zhao, Boyang, Hemann, Michael T., Lauffenburger, Douglas A.

“…The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with…”
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Logic-Based Models for the Analysis of Cell Signaling Networks by Morris, Melody K, Saez-Rodriguez, Julio, Sorger, Peter K, Lauffenburger, Douglas A

“…Computational models are increasingly used to analyze the operation of complex biochemical networks, including those involved in cell signaling networks. Here…”
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Polyfunctional responses by human T cells result from sequential release of cytokines by Han, Qing, Bagheri, Neda, Bradshaw, Elizabeth M., Hafler, David A., Lauffenburger, Douglas A., Love, J. Christopher

“…The release of cytokines by T cells defines a significant part of their functional activity in vivo, and their ability to produce multiple cytokines has been…”
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Artificial neural networks enable genome-scale simulations of intracellular signaling by Nilsson, Avlant, Peters, Joshua M., Meimetis, Nikolaos, Bryson, Bryan, Lauffenburger, Douglas A.

“…Mammalian cells adapt their functional state in response to external signals in form of ligands that bind receptors on the cell-surface. Mechanistically, this…”
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Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding by Kleiman, Laura B., Maiwald, Thomas, Conzelmann, Holger, Lauffenburger, Douglas A., Sorger, Peter K.

“…Epidermal growth factor receptors (ErbB1–4) are oncogenic receptor tyrosine kinases (RTKs) that regulate diverse cellular processes. In this study, we combine…”
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Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution by Zhao, Boyang, Sedlak, Joseph C., Srinivas, Raja, Creixell, Pau, Pritchard, Justin R., Tidor, Bruce, Lauffenburger, Douglas A., Hemann, Michael T.

“…The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature…”
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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme by Nagel, Zachary D, Kitange, Gaspar J, Gupta, Shiv K, Joughin, Brian A, Chaim, Isaac A, Mazzucato, Patrizia, Lauffenburger, Douglas A, Sarkaria, Jann N, Samson, Leona D

“…Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC)…”
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Multiple Reaction Monitoring for Robust Quantitative Proteomic Analysis of Cellular Signaling Networks by Wolf-Yadlin, Alejandro, Hautaniemi, Sampsa, Lauffenburger, Douglas A., White, Forest M.

“…Although recent developments in MS have enabled the identification and quantification of hundreds of phosphorylation sites from a given biological sample,…”
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Migration of Tumor Cells in 3D Matrices Is Governed by Matrix Stiffness along with Cell-Matrix Adhesion and Proteolysis by Zaman, Muhammad H., Trapani, Linda M., Siemeski, Alisha, MacKellar, Drew, Gong, Haiyan, Kamm, Roger D., Wells, Alan, Lauffenburger, Douglas A., Matsudaira, Paul

“…Cell migration on 2D surfaces is governed by a balance between counteracting tractile and adhesion forces. Although biochemical factors such as adhesion…”
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Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis by Nicholas, Dequina, Proctor, Elizabeth A, Raval, Forum M, Ip, Blanche C, Habib, Chloe, Ritou, Eleni, Grammatopoulos, Tom N, Steenkamp, Devin, Dooms, Hans, Apovian, Caroline M, Lauffenburger, Douglas A, Nikolajczyk, Barbara S

“…Numerous studies show that mitochondrial energy generation determines the effectiveness of immune responses. Furthermore, changes in mitochondrial function may…”
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Defining principles of combination drug mechanisms of action by Pritchard, Justin R, Bruno, Peter M, Gilbert, Luke A, Capron, Kelsey L, Lauffenburger, Douglas A, Hemann, Michael T

“…Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many…”
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Discrete SARS-CoV-2 antibody titers track with functional humoral stability by Bartsch, Yannic C., Fischinger, Stephanie, Siddiqui, Sameed M., Chen, Zhilin, Yu, Jingyou, Gebre, Makda, Atyeo, Caroline, Gorman, Matthew J., Zhu, Alex Lee, Kang, Jaewon, Burke, John S., Slein, Matthew, Gluck, Matthew J., Beger, Samuel, Hu, Yiyuan, Rhee, Justin, Petersen, Eric, Mormann, Benjamin, Aubin, Michael de St, Hasdianda, Mohammad A., Jambaulikar, Guruprasad, Boyer, Edward W., Sabeti, Pardis C., Barouch, Dan H., Julg, Boris D., Musk, Elon R., Menon, Anil S., Lauffenburger, Douglas A., Nilles, Eric J., Alter, Galit

“…Antibodies serve as biomarkers of infection, but if sustained can confer long-term immunity. Yet, for most clinically approved vaccines, binding antibody…”
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