Search Results - "Laufer, M"
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Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation
Published in Immunity (Cambridge, Mass.) (17-04-2014)“…How commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understood. Lamina propria (LP) T helper 17 (Th17) cells…”
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Beyond migration—Chemokines in lymphocyte priming, differentiation, and modulating effector functions
Published in Journal of leukocyte biology (01-08-2018)“…Chemokines and their receptors coordinate the positioning of leukocytes, and lymphocytes in particular, in space and time. Discrete lymphocyte subsets,…”
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Role of Mechanotransduction and Tension in T Cell Function
Published in Frontiers in immunology (15-11-2018)“…T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell…”
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4
Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype
Published in PloS one (29-08-2012)“…Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal…”
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Distinct CCR7 glycosylation pattern shapes receptor signaling and endocytosis to modulate chemotactic responses
Published in Journal of leukocyte biology (01-06-2016)“…N‐glycosylation of CCR7 is a determinant of CCR7 signaling and T cell migratory capacity which is modulated by glycosidases released from DCs. The homeostatic…”
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6
Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation
Published in Cell reports (Cambridge) (22-10-2019)“…Chemokine-guided cell migration is pivotal for many immunological and developmental processes. How chemokine receptor signaling persists to guarantee sustained…”
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CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity
Published in Haematologica (Roma) (01-08-2021)“…Adhesive properties of leukemia cells shape the degree of organ infiltration and the extent of leukocytosis. CD44 and the integrin VLA-4, a CD49d/CD29…”
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Benign Uterine Neoplasm as a Cause of Prepubertal Bleeding
Published in Journal of pediatric & adolescent gynecology (01-02-2022)“…Vaginal bleeding in the prepubertal child has several etiologies, including structural anomalies, endocrinologic dysfunction, infection, trauma, foreign body,…”
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CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70
Published in Frontiers in immunology (14-01-2019)“…The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that…”
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Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signaling and Antigen Presentation to CD4+ T Cells
Published in Immunity (Cambridge, Mass.) (25-05-2012)“…Effective major histocompatibility complex-II (MHC-II) antigen presentation from phagocytosed particles requires phagosome-intrinsic Toll-like receptor (TLR)…”
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11
Asymmetric B Cell Division in the Germinal Center Reaction
Published in Science (American Association for the Advancement of Science) (20-01-2012)“…Lifelong antibody responses to vaccination require reorganization of lymphoid tissue and dynamic intercellular communication called the germinal center…”
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Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus
Published in The Journal of experimental medicine (22-12-2008)“…Although the importance of cytotoxic T lymphocytes and neutralizing antibodies for antiviral defense is well known, the antiviral mechanism of Th1 remains…”
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T follicular helper cells in human efferent lymph retain lymphoid characteristics
Published in The Journal of clinical investigation (01-08-2019)“…T follicular helper cells (Tfh), a subset of CD4+ T cells, provide requisite help to B cells in the germinal centers (GC) of lymphoid tissue. GC Tfh are…”
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14
Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?
Published in Nature reviews. Immunology (01-11-2014)“…Key Points Understanding the function of dendritic cells (DCs) forms the basis of the characterization of professional antigen-presenting cells (APCs). DCs…”
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The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies
Published in Frontiers in immunology (04-04-2022)“…The authors of this article, all women who have been deeply committed to the Federation of Clinical Immunology Societies (FOCIS), performed a retrospective…”
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Differentiating mouse embryonic stem cells express markers of human endometrium
Published in Reproductive biology and endocrinology (17-07-2017)“…Modeling early endometrial differentiation is a crucial step towards understanding the divergent pathways between normal and ectopic endometrial development as…”
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The Identity of Human Tissue-Emigrant CD8+ T Cells
Published in Cell (23-12-2020)“…Lymphocyte migration is essential for adaptive immune surveillance. However, our current understanding of this process is rudimentary, because most human…”
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Regulatory T cells occupy an isolated niche in the intestine that is antigen independent
Published in Cell reports (Cambridge) (11-12-2014)“…Regulatory T cells (Tregs) are CD4(+) T cells that maintain immune homeostasis and prevent autoimmunity. Like all CD4(+) T cells, Tregs require…”
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Synthesis of 7-hydroxycoumarins by Pechmann reaction using Nafion resin/silica nanocomposites as catalysts
Published in Journal of catalysis (10-09-2003)“…The reaction of resorcinol with ethyl acetoacetate (Pechmann reaction) or with acrylic acid over novel Nafion resin/silica composite materials with 40 and…”
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War, weapons and watchdogs: an assessment of the legality of new weapons under international human rights law
Published in Cambridge international law journal (01-06-2017)“…This paper will critically analyse the International Committee of the Red Cross' new weapons review and emphasise the importance of considering human rights in…”
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