Search Results - "Laufer, A."

Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology by Gehringer, Matthias, Laufer, Stefan A

“…Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by means of reactive groups, the so-called warheads. Currently, targeting…”
Get full text

Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors by Juchum, Michael, Günther, Marcel, Laufer, Stefan A

“…Abstract Multiple mutations in the EGFR gene are a major cause for the failure of Erlotinib and Gefitinib in the treatment of patients harboring non-small-cell…”
Get full text

Inhibitors of c‑Jun N‑Terminal Kinases: An Update by Koch, Pierre, Gehringer, Matthias, Laufer, Stefan A.

“…The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of…”
Get full text

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors by Pantsar, Tatu, Kaiser, Philipp D., Kudolo, Mark, Forster, Michael, Rothbauer, Ulrich, Laufer, Stefan A.

“…Target residence time plays a crucial role in the pharmacological activity of small molecule inhibitors. Little is known, however, about the underlying causes…”
Get full text

Quantifying inter-individual anatomical variability in the subcortex using 7T structural MRI by Keuken, M.C., Bazin, P.-L., Crown, L., Hootsmans, J., Laufer, A., Müller-Axt, C., Sier, R., van der Putten, E.J., Schäfer, A., Turner, R., Forstmann, B.U.

“…Functional magnetic resonance imaging (MRI) data are usually registered into standard anatomical space. However, standard atlases, such as LPBA40, the…”
Get full text

Cryptic sub-ice geology revealed by a U-Pb zircon study of glacial till in Dronning Maud Land, East Antarctica by Jacobs, J., Opås, B., Elburg, M.A., Läufer, A., Estrada, S., Ksienzyk, A.K., Damaske, D., Hofmann, M.

“…•U-Pb zircon data of glacial drift reveal nature of East Antarcticás cryptic interior.•Evidence of significant extension of the TOAST southward.•TOAST has a…”
Get full text

Post-Campylobacter Guillain Barré Syndrome in the USA: secondary analysis of surveillance data collected during the 2009–2010 novel Influenza A (H1N1) vaccination campaign by Halpin, A. Laufer, Gu, W., Wise, M.E., Sejvar, J. J., Hoekstra, R. M., Mahon, B. E.

“…Guillain Barré syndrome (GBS), which is triggered by autoantibodies produced in response to antigenic stimuli such as certain infections and vaccinations, is…”
Get full text

Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket by Forster, Michael, Chaikuad, Apirat, Bauer, Silke M, Holstein, Julia, Robers, Matthew B, Corona, Cesear R, Gehringer, Matthias, Pfaffenrot, Ellen, Ghoreschi, Kamran, Knapp, Stefan, Laufer, Stefan A

“…Janus kinases (JAKs) are a family of cytoplasmatic tyrosine kinases that are attractive targets for the development of anti-inflammatory drugs given their…”
Get more information

Quantifying inter-individual anatomical variability in the subcortex using 7 T structural MRI by KEUKEN, M. C, BAZIN, P.-L, FORSTMANN, B. U, CROWN, L, HOOTSMANS, J, LAUFER, A, MÜLLER-AXT, C, SIER, R, VAN DER PUTTEN, E. J, SCHAFER, A, TURNER, R

“…Functional magnetic resonance imaging (MRI) data are usually registered into standard anatomical space. However, standard atlases, such as LPBA40, the…”
Get full text

p38 MAPK inhibitors: a patent review (2012 - 2013) by Bühler, Stefanie, Laufer, Stefan A

“…The p38 MAPK is a ubiquitous target in the research-based pharmaceutical industry. It plays a decisive role in the regulation of the production of…”
Get more information

Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19 by Krüger, Nadine, Kronenberger, Thales, Xie, Hang, Rocha, Cheila, Pöhlmann, Stefan, Su, Haixia, Xu, Yechun, Laufer, Stefan A., Pillaiyar, Thanigaimalai

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease…”
Get full text

Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding by Koeberle, Andreas, Shindou, Hideo, Koeberle, Solveigh C., Laufer, Stefan A., Shimizu, Takao, Werz, Oliver

“…The activity of protein kinase B (Akt)—a major kinase promoting cell proliferation and survival—oscillates during the cell cycle. To investigate whether…”
Get full text

The band alignment of Cu2O/ZnO and Cu2O/GaN heterostructures by Kramm, B., Laufer, A., Reppin, D., Kronenberger, A., Hering, P., Polity, A., Meyer, B. K.

“…Using photoelectron spectroscopy, we investigate the band alignments of the Cu2O/ZnO heterointerface and compare the findings with the corresponding values for…”
Get full text

The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma by Spahn, Stephan, Kleinhenz, Fabian, Shevchenko, Ekaterina, Stahl, Aaron, Rasen, Yvonne, Geisler, Christine, Ruhm, Kristina, Klaumuenzer, Marion, Kronenberger, Thales, Laufer, Stefan A., Sundberg-Malek, Holly, Bui, Khac Cuong, Horger, Marius, Biskup, Saskia, Schulze-Osthoff, Klaus, Templin, Markus, Malek, Nisar P., Poso, Antti, Bitzer, Michael

“…Fibroblast growth factor receptor (FGFR)−2 can be inhibited by FGFR-selective or non-selective tyrosine kinase inhibitors (TKIs). Selective TKIs are approved…”
Get full text

Stimulating Effect of Sclareol on Suicidal Death of Human Erythrocytes by Signoretto, Elena, Laufer, Stefan A., Lang, Florian

“…Background/Aims: The diterpene alcohol Sclareol has been proposed for the treatment of malignancy. In analogy to apoptosis of nucleated cells, erythrocytes may…”
Get full text

Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands by Zlotos, Darius P, Kronenberger, Thales, Laufer, Stefan A

“…Hormone-dependent cancers, such as certain types of breast cancer are characterized by over-expression of estrogen receptors (ERs). Anticancer drug conjugates…”
Get full text

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor by Koeberle, Solveigh C, Romir, Johannes, Fischer, Stefan, Koeberle, Andreas, Schattel, Verena, Albrecht, Wolfgang, Grütter, Christian, Werz, Oliver, Rauh, Daniel, Stehle, Thilo, Laufer, Stefan A

“…Studies elucidating the role of p38α MAPK in diverse biological processes are limited by the lack of a specific inhibitor. Skepinone-L is a highly selective…”
Get full text

Outbreaks of Salmonella infections attributed to beef – United States, 1973–2011 by LAUFER, A. S., GRASS, J., HOLT, K., WHICHARD, J. M., GRIFFIN, P. M., GOULD, L. H.

“…Non-typhoidal Salmonella is estimated to be the most common bacterial cause of foodborne illness in the United States, causing an estimated one million…”
Get full text

Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors by Andreev, Stanislav, Pantsar, Tatu, Ansideri, Francesco, Kudolo, Mark, Forster, Michael, Schollmeyer, Dieter, Laufer, Stefan A., Koch, Pierre

“…Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer’s disease. We…”
Get full text

HLA-C Peptide Repertoires as Predictors of Clinical Response during Early SARS-CoV-2 Infection by Olp, Michael D, Laufer, Vincent A, Valesano, Andrew L, Zimmerman, Andrea, Woodside, Kenneth J, Lu, Yee, Lauring, Adam S, Cusick, Matthew F

“…The human leukocyte antigen (HLA) system plays a pivotal role in the immune response to viral infections, mediating the presentation of viral peptides to T…”
Get full text