Search Results - "Lauer, Matthias E."

Cryo-EM structure of alpha-synuclein fibrils by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Mona, Daniel, Ringler, Philippe, Lauer, Matthias E, Riek, Roland, Britschgi, Markus, Stahlberg, Henning

“…Parkinson's disease is a progressive neuropathological disorder that belongs to the class of synucleinopathies, in which the protein alpha-synuclein is found…”
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Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy by Guerrero-Ferreira, Ricardo, Taylor, Nicholas Mi, Arteni, Ana-Andreea, Kumari, Pratibha, Mona, Daniel, Ringler, Philippe, Britschgi, Markus, Lauer, Matthias E, Makky, Ali, Verasdonck, Joeri, Riek, Roland, Melki, Ronald, Meier, Beat H, Böckmann, Anja, Bousset, Luc, Stahlberg, Henning

“…Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological diseases including Parkinson's disease (PD). Previously, we…”
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Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody by Geiger, Martina, Stubenrauch, Kay-Gunnar, Sam, Johannes, Richter, Wolfgang F., Jordan, Gregor, Eckmann, Jan, Hage, Carina, Nicolini, Valeria, Freimoser-Grundschober, Anne, Ritter, Mirko, Lauer, Matthias E., Stahlberg, Henning, Ringler, Philippe, Patel, Jigar, Sullivan, Eric, Grau-Richards, Sandra, Endres, Stefan, Kobold, Sebastian, Umaña, Pablo, Brünker, Peter, Klein, Christian

“…T-cell bispecific antibodies (TCBs) crosslink tumor and T-cells to induce tumor cell killing. While TCBs are very potent, on-target off-tumor toxicity remains…”
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Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs by Plath, Friederike, Ringler, Philippe, Graff-Meyer, Alexandra, Stahlberg, Henning, Lauer, Matthias E, Rufer, Arne C, Graewert, Melissa A, Svergun, Dmitri, Gellermann, Gerald, Finkler, Christof, Stracke, Jan O, Koulov, Atanas, Schnaible, Volker

“…The formation of undesired high molecular weight species such as dimers is an important quality attribute for therapeutic monoclonal antibody formulations…”
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Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress Conditions by Paul, Rajsekhar, Graff-Meyer, Alexandra, Stahlberg, Henning, Lauer, Matthias E., Rufer, Arne C., Beck, Hermann, Briguet, Alexandre, Schnaible, Volker, Buckel, Thomas, Boeckle, Sabine

“…ABSTRACT Purpose To investigate structure and function of different monoclonal antibody (MAb) dimers. Methods MAb dimers were induced by process-related, low…”
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The Contorsbody, an antibody format for agonism: Design, structure, and function by Georges, Guy J., Dengl, Stefan, Bujotzek, Alexander, Hesse, Friederike, Fischer, Jens A.A., Gärtner, Achim, Benz, Jörg, Lauer, Matthias E., Ringler, Philippe, Stahlberg, Henning, Plath, Friederike, Brinkmann, Ulrich, Imhof-Jung, Sabine

“…Contorsbodyis an IgG-derived format which has both Fab arms tethered in close proximity to the carboxy-terminus of the CH3 domain of the Fc. Contorsbodiescan…”
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Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations by Pratsinis, Anna, Fan, Yuchen, Portmann, Michaela, Hammel, Michal, Kou, Ponien, Sarode, Apoorva, Ringler, Philippe, Kovacik, Lubomir, Lauer, Matthias E., Lamerz, Jens, Hura, Greg L., Yen, Chun-Wan, Keller, Michael

“…[Display omitted] Lipid nanoparticles (LNPs) have been widely investigated for nucleic acid therapeutic delivery, and demonstrated their potential in enabling…”
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Investigations into mRNA Lipid Nanoparticles Shelf-Life Stability under Nonfrozen Conditions by Reinhart, Anne-Gaëlle, Osterwald, Anja, Ringler, Philippe, Leiser, Yael, Lauer, Matthias E., Martin, Rainer E., Ullmer, Christoph, Schumacher, Felix, Korn, Claudia, Keller, Michael

“…mRNA LNPs can experience a decline in activity over short periods (ranging from weeks to months). As a result, they require frozen storage and transportation…”
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Highly flexible, IgG-shaped, trivalent antibodies effectively target tumor cells and induce T cell-mediated killing by Dickopf, Steffen, Lauer, Matthias E, Ringler, Philippe, Spick, Christian, Kern, Peter, Brinkmann, Ulrich

“…A novel bispecific antibody format was applied to generate T cell-engaging antibodies. The TriFab format is a trivalent IgG-shaped entity composed of two Fab…”
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Rapid Assessment of Homogeneity and Stability of Amorphous Solid Dispersions by Atomic Force Microscopy—From Bench to Batch by Lauer, Matthias E., Siam, Monira, Tardio, Joseph, Page, Susanne, Kindt, Johannes H., Grassmann, Olaf

“…ABSTRACT Purpose To verify the robustness and fundamental value of Atomic Force Microscopy (AFM) and AFM-based assays to rapidly examine the molecular…”
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Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies by Dickopf, Steffen, Buldun, Can, Vasic, Vedran, Georges, Guy, Hage, Carina, Mayer, Klaus, Forster, Matthias, Wessels, Uwe, Stubenrauch, Kay-Gunnar, Benz, Jörg, Ehler, Andreas, Lauer, Matthias E, Ringler, Philippe, Kobold, Sebastian, Endres, Stefan, Klein, Christian, Brinkmann, Ulrich

“…Driven by the potential to broaden the target space of conventional monospecific antibodies, the field of multi-specific antibody derivatives is growing…”
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Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides by Grossen, Philip, Portmann, Michaela, Koller, Erich, Duschmalé, Martina, Minz, Tanja, Sewing, Sabine, Pandya, Nikhil Janak, van Geijtenbeek, Sabine Kux, Ducret, Axel, Kusznir, Eric-André, Huber, Sylwia, Berrera, Marco, Lauer, Matthias E., Ringler, Philippe, Nordbo, Bettina, Jensen, Marianne Lerbech, Sladojevich, Filippo, Jagasia, Ravi, Alex, Rainer, Gamboni, Remo, Keller, Michael

“…[Display omitted] The natural capacity of extracellular vesicles (EVs) to transport their payload to recipient cells has raised big interest to repurpose EVs…”
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Cholesteryl ester transfer between lipoproteins does not require a ternary tunnel complex with CETP by Lauer, Matthias E., Graff-Meyer, Alexandra, Rufer, Arne C., Maugeais, Cyrille, von der Mark, Elisabeth, Matile, Hugues, D’Arcy, Brigitte, Magg, Christine, Ringler, Philippe, Müller, Shirley A., Scherer, Sebastian, Dernick, Gregor, Thoma, Ralf, Hennig, Michael, Niesor, Eric J., Stahlberg, Henning

“…The cholesteryl ester transfer protein (CETP) enables the transfer of cholesteryl ester (CE) from high-density lipoproteins (HDL) to low-density lipoproteins…”
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Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles by Navarro, Paula P., Genoud, Christel, Castaño-Díez, Daniel, Graff-Meyer, Alexandra, Lewis, Amanda J., de Gier, Yvonne, Lauer, Matthias E., Britschgi, Markus, Bohrmann, Bernd, Frank, Stephan, Hench, Jürgen, Schweighauser, Gabriel, Rozemuller, Annemieke J. M., van de Berg, Wilma D. J., Stahlberg, Henning, Shahmoradian, Sarah H.

“…Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward,…”
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity by Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T, Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J, Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E, Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian

“…High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we…”
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A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion by Lauer, Matthias E, Maurer, Reto, Paepe, Anne T De, Stillhart, Cordula, Jacob, Laurence, James, Rajesh, Kojima, Yuki, Rietmann, Rene, Kissling, Tom, van den Ende, Joost A, Schwarz, Sabine, Grassmann, Olaf, Page, Susanne

“…Hot-melt extrusion is an option to fabricate amorphous solid dispersions and to enhance oral bioavailability of poorly soluble compounds. The selection of…”
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DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity by Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T., Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J., Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E., Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian

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Formation and Healing of Micrometer-Sized Channel Networks on Highly Mobile Au(111) Surfaces by Lauer, Matthias E, Jungmann, Ralf, Kindt, Johannes H, Magonov, Sergei, Fuhrhop, Jurgen-H, Oroudjev, Emin, Hansma, Helen G

“…Practical protocols are presented to reproducibly prepare micrometer-sized Au(111) substrates. Au(111) terraces of micrometer dimensions and atomic smoothness…”
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Porphyrinphosphonate Fibers on Mica and Molecular Rows on Graphite by Lauer, Matthias E, Fuhrhop, Jurgen-Hinrich

“…meso-Tetra(phenyl-p-phosphonate) porphyrin forms rigid and well-separated fibers of monomolecular thickness (2.8 nm) and lengths of several micrometers on mica…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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