Search Results - "Lauer, C"

Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair by Selig, Mischa, Lauer, Jasmin C, Hart, Melanie L, Rolauffs, Bernd

“…Since material stiffness controls many cell functions, we reviewed the currently available knowledge on stiffness sensing and elucidated what is known in the…”
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Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function by Lauer, Jasmin C, Selig, Mischa, Hart, Melanie L, Kurz, Bodo, Rolauffs, Bernd

“…Numerous studies have assembled a complex picture, in which extracellular stimuli and intracellular signaling pathways modulate the chondrocyte phenotype…”
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Therapeutic Modulation of Cell Morphology and Phenotype of Diseased Human Cells towards a Healthier Cell State Using Lignin by Selig, Mischa, Walz, Kathrin, Lauer, Jasmin C, Rolauffs, Bernd, Hart, Melanie L

“…Despite lignin's global abundance and its use in biomedical studies, our understanding of how lignin regulates disease through modulation of cell morphology…”
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Cell morphology as a biological fingerprint of chondrocyte phenotype in control and inflammatory conditions by Selig, Mischa, Azizi, Saman, Walz, Kathrin, Lauer, Jasmin C, Rolauffs, Bernd, Hart, Melanie L

“…Little is known how inflammatory processes quantitatively affect chondrocyte morphology and how single cell morphometric data could be used as a biological…”
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Characterization and In Vitro Cytotoxicity Safety Screening of Fractionated Organosolv Lignin on Diverse Primary Human Cell Types Commonly Used in Tissue Engineering by Menima-Medzogo, Jules A, Walz, Kathrin, Lauer, Jasmin C, Sivasankarapillai, Gopakumar, Gleuwitz, F Robert, Rolauffs, Bernd, Laborie, Marie-Pierre, Hart, Melanie L

“…There is limited data assessing the cytotoxic effects of organosolv lignin with cells commonly used in tissue engineering. Structural and physico-chemical…”
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Room-temperature operation of 3.26μm GaSb-based type-I lasers with quinternary AlGaInAsSb barriers by Grau, M., Lin, C., Dier, O., Lauer, C., Amann, M.-C.

“…Quinternary AlGaInAsSb is introduced as a new barrier material for GaSb-based type-I laser diodes. For wavelengths beyond 3μm, this material improves the…”
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Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo by Do, K. Q., Trabesinger, A. H., Kirsten-Krüger, M., Lauer, C. J., Dydak, U., Hell, D., Holsboer, F., Boesiger, P., Cuénod, M.

“…Schizophrenia is a major psychiatric disease, which affects the centre of the personality, with severe problems of perception, cognition as well as affective…”
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Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts by Lauer, Richard C, Barry, Marc, Smith, Tracey L, Thomas, Andrew Maltez, Wu, Jin, Du, Ruofei, Lee, Ji-Hyun, Rao, Arpit, Dobroff, Andrey S, Arap, Marco A, Nunes, Diana N, Silva, Israel T, Dias-Neto, Emmanuel, Chen, Isan, McCance, Dennis J, Cavenee, Webster K, Pasqualini, Renata, Arap, Wadih

“…We have previously shown that the long non-coding (lnc)RNA ( ; formerly ) functions as a trans-dominant negative oncogene by targeting the previously…”
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Host‐Guest Chemistry of Truncated Tetrahedral Imine Cages with Ammonium Ions by Lauer, Jochen C., Pang, Ziwei, Janßen, Paul, Rominger, Frank, Kirschbaum, Tobias, Elstner, Marcus, Mastalerz, Michael

“…Three shape‐persistent [4+4] imine cages with truncated tetrahedral geometry with different window sizes were studied as hosts for the encapsulation of…”
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PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3 by Salameh, Ahmad, Alessandro K. Lee, Marina Cardó-Vila, Diana N. Nunes, Eleni Efstathiou, Fernanda I. Staquicini, Andrey S. Dobroff, Serena MarchióoÌ, Nora M. Navone, Hitomi Hosoya, Richard C. Lauer, Sijin Wen, Carolina C. Salmeron, Anh Hoang, Irene Newsham, Leandro A. Lima, Dirce M. Carraro, Salvatore Oliviero, Mikhail G. Kolonin, Richard L. Sidman, Kim-Anh Do, Patricia Troncoso, Christopher J. Logothetis, Ricardo R. Brentani, George A. Calin, Webster K. Cavenee, Emmanuel Dias-Neto, Renata Pasqualini, Wadih Arap

“…Prostate cancer antigen 3 ( PCA3 ) is the most specific prostate cancer biomarker but its function remains unknown. Here we identify PRUNE2 , a target…”
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Going viral? Linking the etiology of human prostate cancer to the PCA3 long noncoding RNA and oncogenic viruses by Teixeira, Andre A, Marchiò, Serena, Dias‐Neto, Emmanuel, Nunes, Diana N, da Silva, Israel T, Chackerian, Bryce, Barry, Marc, Lauer, Richard C, Giordano, Ricardo J, Sidman, Richard L, Wheeler, Cosette M, Cavenee, Webster K, Pasqualini, Renata, Arap, Wadih

“…Graphical Abstract The hypothesis is discussed that prostate cancer marker lncRNA PCA3 was introduced into the human genome by an oncogenic virus, and that…”
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SeqSero2: Rapid and Improved Salmonella Serotype Determination Using Whole-Genome Sequencing Data by Zhang, Shaokang, den Bakker, Hendrik C, Li, Shaoting, Chen, Jessica, Dinsmore, Blake A, Lane, Charlotte, Lauer, A C, Fields, Patricia I, Deng, Xiangyu

“…SeqSero, launched in 2015, is a software tool for serotype determination from whole-genome sequencing (WGS) data. Despite its routine use in public health and…”
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[2+3] Amide Cages by Oxidation of [2+3] Imine Cages – Revisiting Molecular Hosts for Highly Efficient Nitrate Binding by Lauer, Jochen C., Bhat, Avinash S., Barwig, Chantal, Fritz, Nathalie, Kirschbaum, Tobias, Rominger, Frank, Mastalerz, Michael

“…The pollution of groundwater with nitrate is a serious issue because nitrate can cause several diseases such as methemoglobinemia or cancer. Therefore,…”
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The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands by Ising, M., Lauer, C.J., Holsboer, F., Modell, S.

“…One of the most characteristic alterations in depression is a disturbed regulation of the hypothalamic-pituitary-adrenocortical (HPA) system. A function test…”
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Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer by Ferrara, Fortunato, Staquicini, Daniela I., Driessen, Wouter H. P., D’Angelo, Sara, Dobroff, Andrey S., Barry, Marc, Lomo, Lesley C., Staquicini, Fernanda I., Cardó-Vila, Marina, Soghomonyan, Suren, Alauddin, Mian M., Flores, Leo G., Arap, Marco A., Lauer, Richard C., Mathew, Paul, Efstathiou, Eleni, Aparicio, Ana M., Troncoso, Patricia, Navone, Nora M., Logothetis, Christopher J., Marchiò, Serena, Gelovani, Juri G., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih

“…Aggressive variant prostate cancers (AVPC) are a clinically defined group of tumors of heterogeneous morphologies, characterized by poor patient survival and…”
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Transformation of Imine Cages into Hydrocarbon Cages by Schick, Tobias H. G., Lauer, Jochen C., Rominger, Frank, Mastalerz, Michael

“…In contrast to organic cages which are formed by exploiting dynamic covalent chemistry, such as boronic ester cages, imine cages, or disulfide cages, those…”
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A Hexagonal Shape‐Persistent Nanobelt of Elongated Rhombic Symmetry with Orthogonal π‐Planes by a One‐Pot Reaction by Lauer, Jochen C., Kohl, Bernd, Braun, Felix, Rominger, Frank, Mastalerz, Michael

“…Triptycenes with their predefined D3h‐symmetry are excellent molecular building blocks to construct shape‐persistent nanobelts having π‐orbitals orthogonal to…”
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Antibody Prevalence of Low-Pathogenicity Avian Influenza and Evaluation of Management Practices in Minnesota Backyard Poultry Flocks by Yendell, S. J., Rubinoff, I., Lauer, D. C., Bender, J. B., Scheftel, J. M.

“…Summary Low‐pathogenicity avian influenza (LPAI) viruses have caused illness in poultry and humans with poultry contact. To determine whether there is evidence…”
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Hormonal Response Pattern in the Combined DEX-CRH Test Is Stable over Time in Subjects at High Familial Risk for Affective Disorders by Modell, M.D, Sieglinde, Lauer, Ph.D, Christoph Johannes, Schreiber, M.D, Wolfgang, Huber, Johannes, Krieg, M.D, Jürgen-Christian, Holsboer, M.D., Ph.D, Florian

“…One of the major neurobiological alterations in depressive disorders consists in a disturbed regulation of the hypothalamic-pituitary-adrenocortical (HPA)…”
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Survival outcomes for advanced kidney cancer patients in the era of targeted therapies by Rao, Arpit, Wiggins, Charles, Lauer, Richard C

“…Advanced renal cell carcinoma (RCC) results in over 14,000 deaths each year in the United States alone. The therapeutic landscape for advanced RCC changed…”
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