Search Results - "Laudermilch, Ethan"

Torsin ATPases: structural insights and functional perspectives by Laudermilch, Ethan, Schlieker, Christian

“…Torsin ATPases are the only members of the AAA+ ATPase family that localize to the endoplasmic reticulum and contiguous perinuclear space. Accordingly, they…”
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Broad neutralization of SARS-related viruses by human monoclonal antibodies by Wec, Anna Z, Wrapp, Daniel, Herbert, Andrew S, Maurer, Daniel P, Haslwanter, Denise, Sakharkar, Mrunal, Jangra, Rohit K, Dieterle, M Eugenia, Lilov, Asparouh, Huang, Deli, Tse, Longping V, Johnson, Nicole V, Hsieh, Ching-Lin, Wang, Nianshuang, Nett, Juergen H, Champney, Elizabeth, Burnina, Irina, Brown, Michael, Lin, Shu, Sinclair, Melanie, Johnson, Carl, Pudi, Sarat, Bortz, 3rd, Robert, Wirchnianski, Ariel S, Laudermilch, Ethan, Florez, Catalina, Fels, J Maximilian, O'Brien, Cecilia M, Graham, Barney S, Nemazee, David, Burton, Dennis R, Baric, Ralph S, Voss, James E, Chandran, Kartik, Dye, John M, McLellan, Jason S, Walker, Laura M

“…Broadly protective vaccines against known and preemergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing…”
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A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition by Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.

“…There is an urgent need for vaccines and therapeutics to prevent and treat COVID-19. Rapid SARS-CoV-2 countermeasure development is contingent on the…”
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Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study by Laudermilch, Ethan, Tsai, Pei-Ling, Graham, Morven, Turner, Elizabeth, Zhao, Chenguang, Schlieker, Christian

“…The human genome encodes four Torsin ATPases, the functions of which are poorly understood. In this study, we use CRISPR/Cas9 engineering to delete all four…”
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Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1 by Chase, Anna R, Laudermilch, Ethan, Wang, Jimin, Shigematsu, Hideki, Yokoyama, Takeshi, Schlieker, Christian

“…TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous…”
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A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants by Haslwanter, Denise, Dieterle, M Eugenia, Wec, Anna Z, O'Brien, Cecilia M, Sakharkar, Mrunal, Florez, Catalina, Tong, Karen, Rappazzo, C Garrett, Lasso, Gorka, Vergnolle, Olivia, Wirchnianski, Ariel S, Bortz, 3rd, Robert H, Laudermilch, Ethan, Fels, J Maximilian, Mengotto, Amanda, Malonis, Ryan J, Georgiev, George I, Quiroz, Jose A, Wrapp, Daniel, Wang, Nianshuang, Dye, Kathryn E, Barnhill, Jason, Dye, John M, McLellan, Jason S, Daily, Johanna P, Lai, Jonathan R, Herbert, Andrew S, Walker, Laura M, Chandran, Kartik, Jangra, Rohit K

“…Most known SARS-CoV-2 neutralizing antibodies (nAbs), including those approved by the FDA for emergency use, inhibit viral infection by targeting the…”
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The Torsin Activator LULL1 Is Required for Efficient Growth of Herpes Simplex Virus 1 by Turner, Elizabeth M, Brown, Rebecca S H, Laudermilch, Ethan, Tsai, Pei-Ling, Schlieker, Christian

“…TorsinA is a membrane-tethered AAA+ ATPase implicated in nuclear envelope dynamics as well as the nuclear egress of herpes simplex virus 1 (HSV-1). The…”
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CRISPR-Cas System: The Current and Emerging Translational Landscape by Bhokisham, Narendranath, Laudermilch, Ethan, Traeger, Lindsay L, Bonilla, Tonya D, Ruiz-Estevez, Mercedes, Becker, Jordan R

“…CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA sequences has transformative…”
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Treatment of severe COVID-19 with convalescent plasma in Bronx, NYC by Yoon, Hyun Ah, Bartash, Rachel, Gendlina, Inessa, Rivera, Johanna, Nakouzi, Antonio, Bortz, 3rd, Robert H, Wirchnianski, Ariel S, Paroder, Monika, Fehn, Karen, Serrano-Rahman, Leana, Babb, Rachelle, Sarwar, Uzma N, Haslwanter, Denise, Laudermilch, Ethan, Florez, Catalina, Dieterle, M Eugenia, Jangra, Rohit K, Fels, J Maximilian, Tong, Karen, Mariano, Margarette C, Vergnolle, Olivia, Georgiev, George I, Herrera, Natalia G, Malonis, Ryan J, Quiroz, Jose A, Morano, Nicholas C, Krause, Gregory J, Sweeney, Joseph M, Cowman, Kelsie, Allen, Stephanie, Annam, Jayabhargav, Applebaum, Ariella, Barboto, Daniel, Khokhar, Ahmed, Lally, Brianna J, Lee, Audrey, Lee, Max, Malaviya, Avinash, Sample, Reise, Yang, Xiuyi A, Li, Yang, Ruiz, Rafael, Thota, Raja, Barnhill, Jason, Goldstein, Doctor Y, Uehlinger, Joan, Garforth, Scott J, Almo, Steven C, Lai, Jonathan R, Gil, Morayma Reyes, Fox, Amy S, Chandran, Kartik, Wang, Tao, Daily, Johanna P, Pirofski, Liise-Anne

“…Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for coronavirus disease…”
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Single-Dilution COVID-19 Antibody Test with Qualitative and Quantitative Readouts by Bortz, 3rd, Robert H, Florez, Catalina, Laudermilch, Ethan, Wirchnianski, Ariel S, Lasso, Gorka, Malonis, Ryan J, Georgiev, George I, Vergnolle, Olivia, Herrera, Natalia G, Morano, Nicholas C, Campbell, Sean T, Orner, Erika P, Mengotto, Amanda, Dieterle, M Eugenia, Fels, J Maximilian, Haslwanter, Denise, Jangra, Rohit K, Celikgil, Alev, Kimmel, Duncan, Lee, James H, Mariano, Margarette C, Nakouzi, Antonio, Quiroz, Jose, Rivera, Johanna, Szymczak, Wendy A, Tong, Karen, Barnhill, Jason, Forsell, Mattias N E, Ahlm, Clas, Stein, Daniel T, Pirofski, Liise-Anne, Goldstein, D Yitzchak, Garforth, Scott J, Almo, Steven C, Daily, Johanna P, Prystowsky, Michael B, Faix, James D, Fox, Amy S, Weiss, Louis M, Lai, Jonathan R, Chandran, Kartik

“…The coronavirus disease 2019 (COVID-19) global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to place an immense…”
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MAVERICC: Marker-free Vaccinia Virus Engineering of Recombinants through in vitro CRISPR/Cas9 Cleavage by Laudermilch, Ethan, Chandran, Kartik

“…[Display omitted] •Current methods for engineering recombinant vaccinia viruses (rVACVs) are inefficient.•MAVERICC uses CRISPR/Cas9 to engineer a wide variety…”
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Torsin ATPases: Harnessing Dynamic Instability for Function by Chase, Anna R, Laudermilch, Ethan, Schlieker, Christian

“…Torsins are essential, disease-relevant AAA+ (ATPases associated with various cellular activities) proteins residing in the endoplasmic reticulum and…”
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TNF-α Limits Serological Memory by Disrupting the Bone Marrow Niche by Aaron, Tonya, Laudermilch, Ethan, Benet, Zachary, Ovando, Luis Jose, Chandran, Kartik, Fooksman, David

“…Both infection and autoimmune disease can disrupt pre-existing Ab titers leading to diminished serological memory, yet the underlying mechanisms are not well…”
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Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2 by Rampello, Anthony J, Laudermilch, Ethan, Vishnoi, Nidhi, Prophet, Sarah M, Shao, Lin, Zhao, Chenguang, Lusk, C Patrick, Schlieker, Christian

“…Nuclear envelope herniations (blebs) containing FG-nucleoporins and ubiquitin are the phenotypic hallmark of Torsin ATPase manipulation. Both the dynamics of…”
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Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes by Lasso, Gorka, Khan, Saad, Allen, Stephanie A, Mariano, Margarette, Florez, Catalina, Orner, Erika P, Quiroz, Jose A, Quevedo, Gregory, Massimi, Aldo, Hegde, Aditi, Wirchnianski, Ariel S, Bortz, 3rd, Robert H, Malonis, Ryan J, Georgiev, George I, Tong, Karen, Herrera, Natalia G, Morano, Nicholas C, Garforth, Scott J, Malaviya, Avinash, Khokhar, Ahmed, Laudermilch, Ethan, Dieterle, M Eugenia, Fels, J Maximilian, Haslwanter, Denise, Jangra, Rohit K, Barnhill, Jason, Almo, Steven C, Chandran, Kartik, Lai, Jonathan R, Kelly, Libusha, Daily, Johanna P, Vergnolle, Olivia

“…The clinical outcome of SARS-CoV-2 infection varies widely between individuals. Machine learning models can support decision making in healthcare by assessing…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative Immunoglobulin G Assays: The Value of Numeric Reporting by Forest, Stefanie K, Orner, Erika P, Goldstein, D. Yitzchak, Wirchnianski, Ariel S, Bortz, Robert H., III, Laudermilch, Ethan, Florez, Catalina, Malonis, Ryan J, Georgiev, George I, Vergnolle, Olivia, Lo, Yungtai, Campbell, Sean T, Barnhill, Jason, Cadoff, Evan M, Lai, Jonathan R, Chandran, Kartik, Weiss, Louis M, Fox, Amy S, Prystowsky, Michael B, Wolgast, Lucia R

“…Context.— Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to…”
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Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis by Herrera, Natalia G, Morano, Nicholas C, Celikgil, Alev, Georgiev, George I, Malonis, Ryan J, Lee, James H, Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B, Yen, Laura Y, Noble, Alex J, Kopylov, Mykhailo, Bonanno, Jeffrey B, Garrett-Thomson, Sarah C, Hayes, David B, Bortz, 3rd, Robert H, Wirchnianski, Ariel S, Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J Maximilian, Dieterle, M Eugenia, Jangra, Rohit K, Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P, Pirofski, Liise-Anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J, Eng, Edward T, Lai, Jonathan R, Almo, Steven C

“…Coronavirus disease 2019 (COVID-19) is a global health crisis caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and there is a…”
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Elucidating Torsin ATPase Function and Regulation at the Nuclear Envelope by Laudermilch, Ethan Michael

“…Torsins are the only members of the AAA+ protein family that localize to the endoplasmic reticulum and the contiguous perinuclear space of the nuclear…”
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Severe Acute Respiratory Syndrome Coronavirus 2 by Campbell, Sean T, Georgiev, George I, Lo, Yungtai, Prystowsky, Michael B, Vergnolle, Olivia, Fox, Amy S, Weiss, Louis M, Barnhill, Jason, Cadoff, Evan M, Lai, Jonathan R, Forest, Stefanie K, Bortz, Robert H., III, Laudermilch, Ethan, Orner, Erika P, Chandran, Kartik, Wolgast, Lucia R, Malonis, Ryan J, Goldstein, D. Yitzchak, Wirchnianski, Ariel S, Florez, Catalina

“…Context.--Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) testing is used for serosurveillance and will be important to…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Qualitative IgG Assays: The Value of Numeric Reporting by Forest, Stefanie K, Orner, Erika P, Goldstein, D Yitzchak, Wirchnianski, Ariel S, Bortz, Robert H, Laudermilch, Ethan, Florez, Catalina, Malonis, Ryan J, Georgiev, George I, Vergnolle, Olivia, Lo, Yungtai, Campbell, Sean T, Barnhill, Jason, Cadoff, Evan M, Lai, Jonathan R, Chandran, Kartik, Weiss, Louis M, Fox, Amy S, Prystowsky, Michael B, Wolgast, Lucia R

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG testing is used for serosurveillance and will be important to evaluate vaccination status…”
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