Search Results - "Lau, Yau Yi"

Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor by Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R

“…A highly potent and selective DGAT-1 inhibitor was identified and used in rodent models of obesity and postprandial chylomicron excursion to validate DGAT-1…”
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Solid phase extraction as a faster alternative to HPLC: application to MS analysis of metabolic stability samples by Inman, Brittany L, Chovan, Linda E, Dandliker, Peter J, Lau, Yau Yi

“…Due to recent advances in high throughput organic synthesis, discovery teams now need to profile increased numbers of analogs in vitro for their absorption,…”
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Semi-automatic high-throughput determination of plasma protein binding using a 96-well plate filtrate assembly and fast liquid chromatography–tandem mass spectrometry by Fung, Eliza N, Chen, Yung-Hsiang, Lau, Yau Yi

“…A semi-automatic, high-throughput method has been developed to rapidly assess plasma protein binding of new chemical entities in drug discovery phase. New…”
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Development of a Novel in Vitro Model to Predict Hepatic Clearance Using Fresh, Cryopreserved, and Sandwich-Cultured Hepatocytes by Lau, Yau Yi, Sapidou, Elpida, Cui, Xiaoming, White, Ronald E, Cheng, K-C

“…Sixty-four compounds with diverse structures were used in evaluation of intrinsic clearance by various hepatocyte preparations from rats, dogs, monkeys, and…”
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EVALUATION OF A NOVEL IN VITRO CACO-2 HEPATOCYTE HYBRID SYSTEM FOR PREDICTING IN VIVO ORAL BIOAVAILABILITY by Lau, Yau Yi, Chen, Yung-Hsiang, Liu, Tong-Tong, Li, Cheng, Cui, Xiaoming, White, Ronald E, Cheng, K-C

“…A novel in vitro Caco-2 hepatocyte hybrid system was set up and tested for its ability to predict the oral bioavailability ( F ) in humans of 24 randomly…”
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Characterization of glucose microsensors for intracellular measurements by Abe, Takayuki, Lau, Yau Yi, Ewing, Andrew G

“…Ultrasmall glucose sensors have been constructed by using platinum-deposited carbon ring microelectrodes with glucose oxidase. Response times as low as 270 ms…”
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Pulse voltammetry in single cells using platinum microelectrodes by Chen, Ta Kung, Lau, Yau Yi, Wong, Danny K. Y, Ewing, Andrew G

“…Multiple pulse voltammetry at platinum microelectrodes is described for intracellular measurements…”
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Rapid hit to lead evaluation of pyrazolo[3,4- d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists by Wang, Xueqing, Kolasa, Teodozyi, El Kouhen, Odile F., Chovan, Linda E., Black-Shaefer, Candace L., Wagenaar, Frank L., Garton, Jennifer A., Moreland, Robert B., Honore, Prisca, Lau, Yau Yi, Dandliker, Peter J., Brioni, Jorge D., Stewart, Andrew O.

“…Hit to lead study of a series of novel and subtype-selective mGluR1 antagonists was discussed. Early ADME evaluation was key to guiding the SAR and generating…”
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Analytical chemistry in microenvironments: single nerve cells by Ewing, Andrew G, Strein, Timothy G, Lau, Yau Yi

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Voltammetric measurement of oxygen in single neurons using platinized carbon ring electrodes by Lau, Yau Yi, Abe, Takayuki, Ewing, Andrew G

“…Naflon-coated ultrasmall platinum ring electrodes have been implanted in the giant dopamine neuron of the pond snail Planorbis corneus, and the oxygen…”
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Determination of pramipexole (U-98,528) in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry by Yau, Yi Lau, Selenka, Jeffrey M., Hanson, Glenn D., Talaat, Rasmy, Ichhpurani, Nita

“…A highly sensitive and selective HPLC-MS-MS method was developed for the determination of pramipexole in human plasma. The analytes, pramipexole and BHT-920…”
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Determination of pramipexole (U-98,528) in human plasma and urine by high-performance liquid chromatography with electrochemical and ultraviolet detection by Yau, Yi Lau, Hanson, Glenn D., Ichhpurani, Nita

“…A sensitive and selective high-performance liquid chromatographic (HPLC) method was developed for the determination of pramipexole in human plasma and urine…”
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Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport by Sulzer, D, Chen, TK, Lau, YY, Kristensen, H, Rayport, S, Ewing, A

“…Whether amphetamine acts principally at the plasma membrane or at synaptic vesicles is controversial. We find that d-amphetamine injection into the Planorbis…”
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Automatic mass spectrometry method development for drug discovery: application in metabolic stability assays by Chovan, Linda E., Black-Schaefer, Candace, Dandliker, Peter J., Lau, Yau Yi

“…High‐throughput metabolic screening has been requested routinely to keep pace with high‐throughput organic synthesis. Liquid chromatography/tandem mass…”
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Semi-automated determination of plasma stability of drug discovery compounds using liquid chromatography–tandem mass spectrometry by Wang, Gangfeng, Hsieh, Yunsheng, Lau, YauYi, Cheng, K.-C, Ng, Kwokei, Korfmacher, Walter A, White, Ronald E

“…A simple procedure for the measurement of stability of drug candidates in plasma was developed to eliminate the traditional labor-intensive and time-consuming…”
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Determination of rifampin in human plasma by high-performance liquid chromatography with ultraviolet detection by Lau, Yau Yi, Hanson, Glenn D., Carel, Barbara J.

“…A simple, specific and sensitive high-performance liquid chromatographic (HPLC) method was developed for the determination of rifampin in human plasma…”
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A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction by Cui, Xiaoming, Palamanda, Jairam, Norton, Laura, Thomas, Ann, Lau, Yau Yi, White, Ronald E., Cheng, K.-C.

“…Introduction: Enzyme induction is undesirable in new drug discovery process, with consequences spanning from auto-induction to toxicity. Cytochrome P450 (CYP)…”
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Electrochemical detection of neurochemicals in and at single neurons by Lau, Yau Yi

“…Electrochemical and separation methods have been found very useful for in vivo measurements of a few easily oxidized neurotransmitters in the nervous system…”
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The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios by YAU YI LAU, KRISHNA, Gopal, YUMIBE, Nathan P, GROTZ, Diane E, SAPIDOU, Elpida, NORTON, Laura, INHOU CHU, CHEN, Cliff, SOARES, A. D, LIN, Chin-Chung

“…The in vivo hepatic extraction ratio of cynomolgus monkeys was correlated with the corresponding in vitro extraction ratios that were determined in monkey…”
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Determination of rifabutin in human plasma by high-performance liquid chromatography with ultraviolet detection by Yau Yi Lau, Hanson, Glenn D., Carel, Barbara J.

“…A simple, specific and sensitive high-performance liquid chromatographic (HPLC) method was developed for the determination of rifabutin in human plasma…”
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