Search Results - "Lau, Wayne B"
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The alternative crosstalk between RAGE and nitrative thioredoxin inactivation during diabetic myocardial ischemia-reperfusion injury
Published in American journal of physiology: endocrinology and metabolism (01-10-2012)“…The receptor for advanced glycation end products (RAGE) and thioredoxin (Trx) play opposing roles in diabetic myocardial ischemia-reperfusion (MI/R) injury. We…”
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Nitrative inactivation of thioredoxin-1 and its role in postischemic myocardial apoptosis
Published in Circulation (New York, N.Y.) (26-09-2006)“…Intracellular proteins involved in oxidative stress and apoptosis are nitrated in diseased tissues but not in normal tissues; definitive evidence to support a…”
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Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity
Published in American journal of physiology: endocrinology and metabolism (01-08-2010)“…Diabetes mellitus (DM) is closely related to cardiovascular morbidity and mortality, but the specific molecular basis linking DM with increased vulnerability…”
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Association of maximum weight with hyperuricemia risk: a retrospective study of 21,414 Chinese people
Published in PloS one (30-11-2012)“…Obesity has been demonstrated to be associated with increased serum uric acid (SUA); however, little is known regarding the relationship between maximum…”
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Hypoadiponectinemia-induced upregulation of microRNA449b downregulating Nrf-1 aggravates cardiac ischemia-reperfusion injury in diabetic mice
Published in Journal of molecular and cellular cardiology (01-09-2023)“…Diabetes enhances myocardial ischemic/reperfusion (MI/R) injury via an incompletely understood mechanism. Adiponectin (APN) is a cardioprotective adipokine…”
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Dickkopf-3 attenuates pressure overload-induced cardiac remodelling
Published in Cardiovascular research (01-04-2014)“…Dickkopf-3 (DKK3), a secreted protein in the Dickkopf family, is expressed in various tissues, including the heart, and has been shown to play an important…”
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Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction
Published in Circulation research (05-02-2010)“…RATIONALE:Patients treated with peroxisome proliferator-activated receptor (PPAR)-γ agonist manifest favorable metabolic profiles associated with increased…”
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Advanced glycation end products accelerate ischemia/reperfusion injury through receptor of advanced end product/nitrative thioredoxin inactivation in cardiac microvascular endothelial cells
Published in Antioxidants & redox signaling (01-10-2011)“…The advanced glycation end products (AGEs) are associated with increased cardiac endothelial injury. However, no causative link has been established between…”
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Concomitant Retrograde Coronary Venous Infusion of Basic Fibroblast Growth Factor Enhances Engraftment and Differentiation of Bone Marrow Mesenchymal Stem Cells for Cardiac Repair after Myocardial Infarction
Published in Theranostics (01-01-2015)“…Basic fibroblast growth factor (bFGF) increases the migration and viability of bone marrow mesenchymal stem cells (MSCs) in vitro. Retrograde coronary venous…”
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HYDROGEN PEROXIDE ENHANCES OSTEOPONTIN EXPRESSION AND MATRIX METALLOPROTEINASE ACTIVITY IN AORTIC VASCULAR SMOOTH MUSCLE CELLS
Published in Clinical and experimental pharmacology & physiology (01-07-2009)“…SUMMARY 1 Restenosis after percutaneous coronary intervention (PCI) is a major clinical complication. However, the underlying mechanisms remain poorly…”
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Abstract 12746: Impaired Autophagic Flux in Ischemic/Reperfused Diabetic Heart and Its Reversal by a Novel Orally Active Adiponectin Receptor Agonist via AMPK-Mediated Autophagosome Formation and AMPK-Independent Autophagosome Clearance
Published in Circulation (New York, N.Y.) (10-11-2015)“…Autophagy is increasingly recognized as an important regulator of myocardial ischemia/reperfusion (MI/R) injury. However, whether and how autophagy is altered…”
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The interaction of HAb18G/CD147 with integrin α6β1 and its implications for the invasion potential of human hepatoma cells
Published in BMC cancer (23-09-2009)“…Abstract Background HAb18G/CD147 plays pivotal roles in invasion by hepatoma cells, but the underlying mechanism remains unclear. Our previous study…”
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Abstract 13467: Ctrp9 Regulates Mitophagic Degradation Against Myocardial Ischemia/rRperfusion Injury Through Modulating Cathepsin Activity
Published in Circulation (New York, N.Y.) (19-11-2019)“…BackgroundMitochondrial dysfunction and associated mitophagic flux disturbance contribute to myocardial ischemia/reperfusion (MI/R) injury. Cardiokine CTRP9…”
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Chief complaints associated with mortality involving civilian transport after Wen-chuan earthquake
Published in European journal of emergency medicine (01-10-2014)“…OBJECTIVESPrevious studies have reported that civilian transport is a mortality risk factor in low-resource communities. Few studies have analyzed the chief…”
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Abstract 212: Globular Domain of Adiponectin Attenuates Post-Ischemia Myocardial Oxidative/Nitrative Stress in an AMPK-Independent Fashion
Published in Circulation (New York, N.Y.) (28-10-2008)“…Abstract only Reduced plasma adiponectin (APN) level not only contributes to the increased incidence of MI in diabetic patients, but also plays a causative…”
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Abstract 15793: N-Cadherin Overexpression in Adipocyte Derived Mesenchymal Stem Cells Enhances Its Cardioprotective Effects
Published in Circulation (New York, N.Y.) (06-11-2018)“…IntroductionToxic microenvironment restricted the engrafted mesenchymal stem cells survival and reparative effects on ischemic heart failure (IHF). We recently…”
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