Search Results - "Lau, Vivian W."

IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells by Mazet, Julie M., Mahale, Jagdish N., Tong, Orion, Watson, Robert A., Lechuga‐Vieco, Ana Victoria, Pirgova, Gabriela, Lau, Vivian W. C., Attar, Moustafa, Koneva, Lada A., Sansom, Stephen N., Fairfax, Benjamin P., Gérard, Audrey

“…IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to…”
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Induced Pluripotent Stem Cell-Derived Neural Stem Cell Therapy Enhances Recovery in an Ischemic Stroke Pig Model by Baker, Emily W., Platt, Simon R., Lau, Vivian W., Grace, Harrison E., Holmes, Shannon P., Wang, Liya, Duberstein, Kylee Jo, Howerth, Elizabeth W., Kinder, Holly A., Stice, Steve L., Hess, David C., Mao, Hui, West, Franklin D.

“…Induced pluripotent stem cell-derived neural stem cells (iNSCs) have significant potential as an autologous, multifunctional cell therapy for stroke, which is…”
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The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity by Helsen, Christopher W., Hammill, Joanne A., Lau, Vivian W. C., Mwawasi, Kenneth A., Afsahi, Arya, Bezverbnaya, Ksenia, Newhook, Lisa, Hayes, Danielle L., Aarts, Craig, Bojovic, Bojana, Denisova, Galina F., Kwiecien, Jacek M., Brain, Ian, Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.

“…Engineering T cells with chimeric antigen receptors (CARs) is an effective method for directing T cells to attack tumors, but may cause adverse side effects…”
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Evaluation of therapeutic phenobarbital concentrations and application of a classification system for seizures in cats: 30 cases (2004-2013) by Finnerty, Katherine E, Barnes Heller, Heidi L, Mercier, Miyu N, Giovanella, Carley J, Lau, Vivian W, Rylander, Helena

“…To determine the percentage of cats with a phenobarbital (PB) concentration between 15 and 45 μg/mL that had a ≥ 50% reduction in the number of seizures and to…”
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation by Senger, Kate, Pham, Victoria C, Varfolomeev, Eugene, Hackney, Jason A, Corzo, Cesar A, Collier, Jenna, Lau, Vivian W C, Huang, Zhiyu, Hamidzhadeh, Kajal, Caplazi, Patrick, Peng, Ivan, Setiadi, A Francesca, Francis, Ross, Paler-Martinez, Andres, Kwon, Youngsu C, Ramirez-Carrozzi, Vladimir, Sun, Yonglian, Grigg, Patricia W, Roose-Girma, Merone, Jeet, Surinder, Barck, Kai H, Pham, Anna, Ota, Naruhisa, Ha, Connie, Stinson, Jeremy, Guillory, Joseph, Tam, Lucinda, Modrusan, Zora, Emson, Claire, McKenzie, Brent S, Townsend, Michael J, Carano, Richard A D, Warming, Søren, Vucic, Domagoj, DeVoss, Jason, Lee, Wyne P, Lill, Jennie R, Zarrin, Ali A

“…Tumor progression locus 2 (TPL2; also known as MAP3K8) is a mitogen-activated protein kinase (MAPK) kinase kinase (MAP3K) that phosphorylates the MAPK kinases…”
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Human iNPC therapy leads to improvement in functional neurologic outcomes in a pig ischemic stroke model by Lau, Vivian W., Platt, Simon R., Grace, Harrison E., Baker, Emily W., West, Franklin D.

“…Introduction Stroke is the leading cause of disability in the United States but current therapies are limited with no regenerative potential. Previous…”
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Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons by Lau, V.W.Y, Journoud, M, Jones, P.J.H

“…Background: Because of hyperglycemia and hyperinsulinemia, diabetic persons have higher cholesterol synthesis and lower cholesterol absorption rates than do…”
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Immunotherapy for peanut allergy by Lee, T H, Chan, June, Lau, Vivian W Y, Lee, W L, Lau, P C, Lo, M H

“…Peanut allergy is one of the commonest food hypersensitivities causing fatal or near-fatal reactions. There is, currently, no preventive treatment and the…”
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Immunogenicity of Varicella Vaccine and Immunologic Predictors of Response in a Cohort of Elderly Nursing Home Residents by Lelic, Alina, Verschoor, Chris P., Lau, Vivian W. C., Parsons, Robin, Evelegh, Carole, Bowdish, Dawn M., Bramson, Jonathan L., Loeb, Mark B.

“…Background. Little is known about the immunogenicity of live-attenuated Oka/Merck varicella zoster virus (VZV)–containing vaccine (hereafter, "varicella…”
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Pharmacokinetic evaluation of novel midazolam gel formulations following buccal administration to healthy dogs by Aldawsari, Mohammed F, Lau, Vivian W, Babu, Ramapuram J, Arnold, Robert D, Platt, Simon R

“…OBJECTIVE To determine the physiochemical properties and pharmacokinetics of 3 midazolam gel formulations following buccal administration to dogs. ANIMALS 5…”
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A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity by Hammill, Joanne A., Kwiecien, Jacek M., Dvorkin-Gheva, Anna, Lau, Vivian W.C., Baker, Christopher, Wu, Ying, Bezverbnaya, Ksenia, Aarts, Craig, Heslen, Christopher W., Denisova, Galina F., Derocher, Heather, Milne, Katy, Nelson, Brad H., Bramson, Jonathan L.

“…Tumor-targeted chimeric antigen receptor (CAR)-engineered T lymphocytes (CAR-T cells) have demonstrated striking clinical success, but their use has been…”
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Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model by Platt, Simon R, Holmes, Shannon P, Howerth, Elizabeth W, Duberstein, Kylee Jo J, Dove, C Robert, Kinder, Holly A, Wyatt, Emily L, Linville, Amie V, Lau, Vivian W, Stice, Steven L, Hill, William D, Hess, David C, West, Franklin D

“…Efforts to develop stroke treatments have met with limited success despite an intense need to produce novel treatments. The failed translation of many of these…”
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Perception of safe robot speed in virtual and real industrial environments by Duffy, Vincent G., Or, Calvin K.L., Lau, Vivian W.M.

“…The purpose of this project was to study the influences of dynamic virtual objects in an Internet‐based virtual industrial environment. The main objectives of…”
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Abstract WP115: Transplanted Induced Neural Stem Cells Differentiate and Integrate Into the Brain Parenchyma of Ischemic Stroke Pigs Leading to Improved Tissue Recovery by Baker, Emily W, Platt, Simon R, Holmes, Shannon P, Wang, Liya, Lau, Vivian W, Grace, Harrison E, Kinder, Holly A, Howerth, Elizabeth W, Duberstein, Kylee Jo J, Stice, Steven L, Hess, David C, Mao, Hui, West, Franklin D

“…Abstract only Studies in rodents have provided evidence that induced pluripotent stem cell derived neural stem cells (iNSCs) have a multifunctional role in…”
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Abstract TP109: Quantitative Gait Analysis Demonstrates Significant Changes in Motor Function Post-ischemic Stroke and Simulated Intraparenchymal Therapeutic Delivery in a Porcine Model by Kaiser, Erin E, Duberstein, Kylee J, Platt, Simon R, Lau, Vivian W, Nguyen, Trinh, Baker, Emily W, Grace, Harrison E, Howerth, Elizabeth W, Holmes, Shannon P, Wang, Liya, Stice, Steve L, Mao, Hui, West, Franklin D

“…Abstract only Severity of stroke and subsequent recovery can be measured through gait changes of affected individuals. Recent failures of therapies tested in…”
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Abstract 130: Induced Neural Stem Cell Treated Stroke Pigs Show Improved White Matter Integrity and Brain Metabolism Post-ischemic Stroke by West, Franklin D, Platt, Simon R, Holmes, Shannon P, Wang, Liya, Lau, Vivian W, Baker, Emily W, Grace, Harrison E, Howerth, Elizabeth W, Duberstein, Kylee J, Stice, Steven L, Hess, David C, Mao, Hui

“…Abstract only Recent studies in rodent stroke models have shown that induced pluripotent stem cell derived neural stem cells (iNSCs) can lead to a significant…”
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Plant sterols are efficacious in lowering plasma LDL and non-HDL cholesterol in hypercholesterolemic type 2 diabetic and nondiabetic persons2–3 by Lau, Vivian WY, Journoud, Mélanie, Jones, Peter JH

“…Background: Because of hyperglycemia and hyperinsulinemia, diabetic persons have higher cholesterol synthesis and lower cholesterol absorption rates than do…”
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