Search Results - "Lau, Thomas"
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Transition metal atom doping of the basal plane of MoS2 monolayer nanosheets for electrochemical hydrogen evolution
Published in Chemical science (Cambridge) (2018)“…Surface sites of extensively exposed basal planes of MoS2 monolayer nanosheets, prepared via BuLi exfoliation of MoS2, have been doped with transition metal…”
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Engineering Monolayer 1T-MoS2 into a Bifunctional Electrocatalyst via Sonochemical Doping of Isolated Transition Metal Atoms
Published in ACS catalysis (02-08-2019)“…There has been an intense research effort to develop 2-H MoS2 based catalysts to reduce or eliminate the use of Pt/C at higher metal loading for the hydrogen…”
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3
Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses
Published in Immunity (Cambridge, Mass.) (13-10-2020)“…The SARS-CoV-2 pandemic has resulted in millions of infections, yet the role of host immune responses in early COVID-19 pathogenesis remains unclear. By…”
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Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways
Published in European journal of nutrition (01-02-2014)“…PURPOSE: To investigate the protective mechanisms of an 85 % pure extract of (−) epigallocatechin gallate (EGCG) in the development of fibrosis, oxidative…”
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Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
Published in Molecular cancer research (02-05-2024)“…NDC80 complex (NDC80C) is composed of four subunits (SPC24, SPC25, NDC80, and NUF2) and is vital for kinetochore-microtubule (KT-MT) attachment during mitosis…”
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6
Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase
Published in Proceedings of the National Academy of Sciences - PNAS (29-09-2015)“…Characterization of the proteome of organelles and subcellular domains is essential for understanding cellular organization and identifying protein complexes…”
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Platelets promote epileptic seizures by modulating brain serotonin level, enhancing neuronal electric activity, and contributing to neuroinflammation and oxidative stress
Published in Progress in neurobiology (01-05-2020)“…[Display omitted] •Platelets substantially contribute to the severity of epileptic seizures.•During epileptic seizures, platelets enter CNS and secrete…”
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Longitudinal change of quality of life in the first five years of survival among disease-free Chinese breast cancer survivors
Published in Quality of life research (01-06-2021)“…Purpose This study aimed to investigate changes of QoL during the first 5 years of survival among disease-free Chinese breast cancer survivors. Methods A…”
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Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4 )-induced liver injury in mice
Published in Toxicology (Amsterdam) (29-06-2010)“…Abstract The anti-inflammatory and antioxidant effects of epigallocatechin-3-gallate (EGCG) are considered important forces in attenuate liver injury and…”
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Quality of Life Associated with Nausea and Vomiting from Anthracycline‐Based Chemotherapy: A Pooled Data Analysis from Three Prospective Trials
Published in The oncologist (Dayton, Ohio) (01-12-2021)“…Background There is limited work on the impact of chemotherapy‐induced nausea and vomiting (CINV) on quality of life (QoL) in adriamycin‐cyclophosphamide…”
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Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease
Published in Neurobiology of aging (01-05-2019)“…Although it was suggested that gangliosides play an important role in the binding of amyloid fragments to neuronal cells, the exact role of gangliosides in…”
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12
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies
Published in Cell host & microbe (14-04-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a burst in the upper respiratory portal for high transmissibility. To…”
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Dynamic Changes of Post-Radiotherapy Plasma Epstein-Barr Virus DNA in a Randomized Trial of Adjuvant Chemotherapy Versus Observation in Nasopharyngeal Cancer
Published in Clinical cancer research (15-05-2021)“…To study the dynamic changes in plasma Epstein-Barr virus (pEBV) DNA after radiotherapy in nasopharyngeal cancer (NPC). We conducted a randomized controlled…”
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Risk Factors Associated with Chemotherapy-Induced Nausea and Vomiting Among Women with Breast Cancer Receiving Highly Emetogenic Chemotherapy: Individual Patient-Based Analysis of Three Prospective Antiemetic Trials
Published in Cancer management and research (01-01-2024)“…Although risk factors related to chemotherapy-induced nausea and vomiting (CINV) have been identified in previous studies, only a few studies have evaluated…”
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Leveraging nonstructural data to predict structures and affinities of protein–ligand complexes
Published in Proceedings of the National Academy of Sciences - PNAS (21-12-2021)“…Over the past five decades, tremendous effort has been devoted to computational methods for predicting properties of ligands—i.e., molecules that bind…”
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In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier
Published in Drug metabolism and disposition (01-04-2019)“…Understanding the quantitative implications of P-glycoprotein and breast cancer resistance protein efflux is a key hurdle in the design of effective, centrally…”
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Contributions of a Disulfide Bond and a Reduced Cysteine Side Chain to the Intrinsic Activity of the High-Density Lipoprotein Receptor SR-BI
Published in Biochemistry (Easton) (18-12-2012)“…The high-density lipoprotein (HDL) receptor scavenger receptor class B, type I (SR-BI), binds HDL and mediates selective cholesteryl ester uptake. SR-BI’s…”
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Absolute Quantification of Toxicological Biomarkers via Mass Spectrometry
Published in Methods in molecular biology (Clifton, N.J.) (2017)“…With the advent of "-omics" technologies there has been an explosion of data generation in the field of toxicology, as well as many others. As new candidate…”
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Kinesins regulate the heterogeneity in centrosome clustering after whole-genome duplication
Published in Life science alliance (01-10-2024)“…After whole-genome duplication (WGD), tetraploid cells can undergo multipolar mitosis or pseudo-bipolar mitosis with clustered centrosomes. Kinesins play a…”
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Cyclooxygenase inhibitors protect d-galactosamine/lipopolysaccharide induced acute hepatic injury in experimental mice model
Published in Food and chemical toxicology (01-03-2012)“…► COX inhibitors ameliorated LPS/Gal induced acute liver damage. ► Hepatic oxidative stress and inflammation induced by LPS/Gal were attenuated. ► C/EBP-α and…”
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