Search Results - "Lau, Sally"

Squamous cell lung cancer: Current landscape and future therapeutic options by Lau, Sally C.M., Pan, Yuanwang, Velcheti, Vamsidhar, Wong, Kwok Kin

“…Squamous cell lung cancers (lung squamous cell carcinomas [LUSCs]) are associated with high mortality and a lack of therapies specific to this disease…”
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Immunotherapy in non-small cell lung cancer: Past, present, and future directions by Punekar, Salman R., Shum, Elaine, Grello, Cassandra Mia, Lau, Sally C., Velcheti, Vamsidhar

“…Many decades in the making, immunotherapy has demonstrated its ability to produce durable responses in several cancer types. In the last decade, immunotherapy…”
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The Value of Comprehensive Molecular Profiling in Early Stage Lung Cancer by Lau, Sally C M

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Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy by Boukhaled, Giselle M., Gadalla, Ramy, Elsaesser, Heidi J., Abd-Rabbo, Diala, Quevedo, Rene, Yang, S. Y. Cindy, Guo, Mengdi, Wang, Ben X., Noamani, Babak, Gray, Diana, Lau, Sally C. M., Taylor, Kirsty, Aung, Kyaw, Spreafico, Anna, Hansen, Aaron R., Saibil, Samuel D., Hirano, Naoto, Guidos, Cynthia, Pugh, Trevor J., McGaha, Tracy L., Ohashi, Pamela S., Sacher, Adrian G., Butler, Marcus O., Brooks, David G.

“…Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition…”
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition by Pan, Yuanwang, Han, Han, Hu, Hai, Wang, Hua, Song, Yueqiang, Hao, Yuan, Tong, Xinyuan, Patel, Ayushi S., Misirlioglu, Selim, Tang, Sittinon, Huang, Hsin-Yi, Geng, Ke, Chen, Ting, Karatza, Angeliki, Sherman, Fiona, Labbe, Kristen E., Yang, Fan, Chafitz, Alison, Peng, Chengwei, Guo, Chenchen, Moreira, Andre L., Velcheti, Vamsidhar, Lau, Sally C.M., Sui, Pengfei, Chen, Haiquan, Diehl, J. Alan, Rustgi, Anil K., Bass, Adam J., Poirier, John T., Zhang, Xiaoyang, Ji, Hongbin, Zhang, Hua, Wong, Kwok-Kin

“…Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with limited treatment options. KMT2D is one of the most frequently mutated genes…”
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Selpercatinib as the Guardian of the Central Nervous System for Patients With RET Fusion-Positive NSCLC? by Lau, Sally C M, Ou, Sai-Hong Ignatius

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Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model by Cheng, Connie, Lau, Sally K M, Doering, Laurie C

“…Astrocytes are key participants in various aspects of brain development and function, many of which are executed via secreted proteins. Defects in astrocyte…”
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Tobacco exposure and immunotherapy response in PD-L1 positive lung cancer patients by Li, Janice J.N., Karim, Khizar, Sung, Mike, Le, Lisa W., Lau, Sally C.M., Sacher, Adrian, Leighl, Natasha B.

“…•Smoking is associated with significantly better anti-PD-1 monotherapy response.•Smoking history is a significant factor even after adjusting for PD-L1…”
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Dacomitinib in the Management of Advanced Non-Small-Cell Lung Cancer by Lau, Sally C. M., Batra, Ullas, Mok, Tony S. K., Loong, Herbert H.

“…The use of targeted therapy in the management of epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer is an important milestone in the…”
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Is the Southern Ocean ecosystem primed for change or at the cliff edge? by Lau, Sally C. Y., Strugnell, Jan M.

“…The Southern Ocean is experiencing unprecedented environmental risks and consequences from current climate change. It is unclear how the benthic fauna, which…”
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Subtypes of EGFR- and HER2-Mutant Metastatic NSCLC Influence Response to Immune Checkpoint Inhibitors by Lau, Sally C.M., Fares, Aline Fusco, Le, Lisa W., Mackay, Kate M., Soberano, Spencer, Chan, Sze Wah, Smith, Elliot, Ryan, Malcolm, Tsao, Ming Sound, Bradbury, Penelope A., Pal, Prodipto, Shepherd, Frances A., Liu, Geoffrey, Leighl, Natasha B., Sacher, Adrian G.

“…The efficacy of immune checkpoint inhibitors (ICIs) is low among EGFR-mutated non–small-cell lung cancer (NSCLC), although prolonged responses have…”
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Genomic insights of evolutionary divergence and life history innovations in Antarctic brittle stars by Lau, Sally C. Y., Strugnell, Jan M., Sands, Chester J., Silva, Catarina N. S., Wilson, Nerida G.

“…Understanding the drivers of evolutionary innovation provides a crucial perspective of how evolutionary processes unfold across taxa and ecological systems. It…”
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Detecting glacial refugia in the Southern Ocean by Lau, Sally C. Y., Wilson, Nerida G., Silva, Catarina N. S., Strugnell, Jan M.

“…Throughout the Quaternary, the continental‐based Antarctic ice sheets expanded and contracted repeatedly. Evidence suggests that during glacial maxima,…”
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Emerging biological archives can reveal ecological and climatic change in Antarctica by Strugnell, Jan M., McGregor, Helen V., Wilson, Nerida G., Meredith, Karina T., Chown, Steven L., Lau, Sally C. Y., Robinson, Sharon A., Saunders, Krystyna M.

“…Anthropogenic climate change is causing observable changes in Antarctica and the Southern Ocean including increased air and ocean temperatures, glacial melt…”
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Genomic evidence for West Antarctic Ice Sheet collapse during the Last Interglacial by Lau, Sally C Y, Wilson, Nerida G, Golledge, Nicholas R, Naish, Tim R, Watts, Phillip C, Silva, Catarina N S, Cooke, Ira R, Allcock, A Louise, Mark, Felix C, Linse, Katrin, Strugnell, Jan M

“…The marine-based West Antarctic Ice Sheet (WAIS) is considered vulnerable to irreversible collapse under future climate trajectories, and its tipping point may…”
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Restoration potential of Asian oysters on heavily developed coastlines by Lau, Sally C. Y., Thomas, Marine, Hancock, Boze, Russell, Bayden D.

“…Reef‐building oysters historically provided the main structural and ecological component of temperate and subtropical coastal waters globally. While the loss…”
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To Crush or Not to Crush: Administering Dabrafenib and Trametinib Through a Nasogastric Tube in a Critically Ill Patient With Nonsmall Cell Lung Cancer - A Case Report and Review of Literature of Targeted Therapies Given Through Enteral Feeding Tubes by Jang, Charley, Lau, Sally Cm, Velcheti, Vamsidhar

“…Up to 71% of lung cancer patients admitted to the ICU are newly diagnosed. The decision to initiate cancer directed treatments in lung cancer patients admitted…”
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Outcome Differences Between First- and Second-generation EGFR Inhibitors in Advanced EGFR Mutated NSCLC in a Large Population-based Cohort by Lau, Sally C., Chooback, Negar, Ho, Cheryl, Melosky, Barbara

“…Second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) appear superior to first-generation TKIs in clinical trials, but at…”
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Chromosome-scale genome assembly of the tropical abalone (Haliotis asinina) by Barkan, Roy, Cooke, Ira, Watson, Sue-Ann, Lau, Sally C. Y., Strugnell, Jan M.

“…Abalone (family Haliotidae) are an ecologically and economically significant group of marine gastropods that can be found in tropical and temperate waters. To…”
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Something old, something new: Historical perspectives provide lessons for blue growth agendas by Caswell, Bryony A., Klein, Emily S., Alleway, Heidi K., Ball, Johnathan E., Botero, Julián, Cardinale, Massimiliano, Eero, Margit, Engelhard, Georg H., Fortibuoni, Tomaso, Giraldo, Ana‐Judith, Hentati‐Sundberg, Jonas, Jones, Peter, Kittinger, John N., Krause, Gesche, Lajus, Dmitry L., Lajus, Julia, Lau, Sally C.Y., Lescrauwaet, Ann‐Katrien, MacKenzie, Brian R., McKenzie, Matthew, Ojaveer, Henn, Pandolfi, John M., Raicevich, Saša, Russell, Bayden D., Sundelöf, Andreas, Thorpe, Robert B., zu Ermgassen, Philine S.E., Thurstan, Ruth H.

“…The concept of “blue growth,” which aims to promote the growth of ocean economies while holistically managing marine socioecological systems, is emerging…”
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