Cardiovascular risk factors in pre-pubertal Malays: Effects of diabetic parentage

Abstract Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children...

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Bibliographic Details
Published in:	Diabetes research and clinical practice Vol. 76; no. 1; pp. 119 - 125
Main Authors:	Choo, Keng Ee, Lau, Kim Bee, Davis, Wendy A, Chew, Peng Hong, Jenkins, Alicia J, Davis, Timothy M.E
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-04-2007
Subjects:	Adult Blood Glucose - analysis Blood Pressure Body Mass Index Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular risk factors Case-Control Studies Child Cholesterol, HDL - blood Creatinine - blood Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Endocrinology & Metabolism Ethnicity Familial clustering Family Fasting Glycated Hemoglobin A - analysis Humans Insulin - blood Malaysia - epidemiology Middle Aged Pedigree Pre-pubertal Principal Component Analysis - methods Risk Factors Triglycerides - blood Type 2 diabetes Urban Population - statistics & numerical data Uric Acid - blood Waist-Hip Ratio Type 2 diabetes Ethnicity Familial clustering Cardiovascular risk factors Pre-pubertal
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Summary:	Abstract Diabetes prevalence is increasing rapidly in Asian populations but the influence of a family history of diabetes on cardiovascular risk is unknown. To assess this relationship, 120 urban-dwelling Malays were recruited to a cross-sectional case-control study. Sixty were pre-pubertal children, 30 of diabetic parentage (Group 1) and 30 with no diabetes family history (Group 2). Group 1 and 2 subjects were the offspring of adults with (Group 3) or without (Group 4) type 2 diabetes. Subjects were assessed for clinical and biochemical variables defining cardiovascular risk. Principal component analysis assessed clustering of variables in the children. Group 1 subjects had a higher mean waist:hip ratio, diastolic blood pressure and HbA1c than those in Group 2, and a lower HDL:total cholesterol ratio ( P < 0.03). Although there were no correlations between Group 1 and 3 subjects for cardiovascular risk variables, significant associations were found in Groups 2 and 4, especially HbA1c and insulin sensitivity ( P ≤ 0.004). Of five separate clusters of variables (factors) identified amongst the children, the strongest comprised diabetic parentage, HbA1c , insulin sensitivity and blood pressure. Features of the metabolic syndrome are becoming evident in the young non-obese children of diabetic Malays, suggesting that lifestyle factors merit particular attention in this group.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2006.08.006