Search Results - "Lau, Keith"

Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma by D'souza, Simmone, Lau, Keith Ck, Coffin, Carla S, Patel, Trushar R

“…Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis, cancer, and liver failure. Liver cancer is the…”
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Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA by Meier-Stephenson, Vanessa, Badmalia, Maulik D., Mrozowich, Tyler, Lau, Keith C.K., Schultz, Sarah K., Gemmill, Darren L., Osiowy, Carla, van Marle, Guido, Coffin, Carla S., Patel, Trushar R.

“…Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing cirrhosis and…”
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VSV∆M51 drives CD8+ T cell-mediated tumour regression through infection of both cancer and non-cancer cells by Rajwani, Jahanara, Vishnevskiy, Daniil, Turk, Madison, Naumenko, Victor, Gafuik, Chris, Kim, Dae-Sun, Mah, Laura K., Snelling, Shannon, Gonzales, Gerone A., Xue, Jingna, Chanda, Ayan, Potts, Kyle G., Todesco, Hayley M., Lau, Keith C. K., Hildebrand, Karys M., Chan, Jennifer A., Liao, Shan, Monument, Michael J., Hyrcza, Martin, Bose, Pinaki, Jenne, Craig N., Canton, Johnathan, Zemp, Franz J., Mahoney, Douglas J.

“…Oncolytic viruses (OV) are designed to selectively infect and kill cancer cells, while simultaneously eliciting antitumour immunity. The mechanism is expected…”
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Impact of Hepatitis B Virus Genetic Variation, Integration, and Lymphotropism in Antiviral Treatment and Oncogenesis by Lau, Keith C K, Burak, Kelly W, Coffin, Carla S

“…Chronic Hepatitis B Virus (HBV) infection poses a significant global health burden. Although, effective treatment and vaccinations against HBV are available,…”
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Pathogenesis of Henoch-Schönlein purpura nephritis by Lau, Keith K., Suzuki, Hitoshi, Novak, Jan, Wyatt, Robert J.

“…The severity of renal involvement is the major factor determining the long-term outcome of children with Henoch-Schönlein purpura (HSP) nephritis (HSPN)…”
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Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants by Lau, Keith C K, Joshi, Shivali S, Mahoney, Douglas J, Mason, Andrew L, van Marle, Guido, Osiowy, Carla, Coffin, Carla S

“…Chronic hepatitis B virus (HBV) infection is the leading cause of hepatocellular carcinoma (HCC) world-wide. HBV variants, particularly the G1896A pre-core…”
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Analysis of serum hepatitis B virus RNA levels in a multiethnic cohort of pregnant chronic hepatitis B carriers by Patel, Nishi H., Joshi, Shivali S., Lau, Keith C.K., Castillo, Eliana, Coffin, Carla S.

“…•Increasing research suggesting that HBV serum RNA levels may serve as a new serum biomarker, reflecting intrahepatic HBV cccDNA activity in chronic HBV…”
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Prognostic Value of Controlled Attenuation Parameter by Transient Elastography by Liu, Ken, Wong, Vincent Wai-Sun, Lau, Keith, Liu, Sienna Du, Tse, Yee-Kit, Yip, Terry Cheuk-Fung, Kwok, Raymond, Chan, Alex Yiu-Wa, Chan, Henry Lik-Yuen, Wong, Grace Lai-Hung

“…Liver stiffness measurement (LSM) by transient elastography (TE) has been shown to predict outcomes in patients with liver disease. While controlled…”
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Hepatitis B virus (HBV) genome detection and genotyping in virally suppressed patients using nested polymerase chain reaction-based Sanger sequencing by Lau, Keith CK, Osiowy, Carla, Coffin, Carla S

“…Hepatitis B virus (HBV) genotypes have important clinical implications. Current genotyping methods are less sensitive in patients with ultra-low HBV viral…”
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Relief of keloid-associated symptoms by topical application of thin plastic sheets by Ing, Todd, Tang, Hon-Lok, Lau, Keith

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Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms by Kim, Dae-Sun, Dastidar, Himika, Zhang, Chunfen, Zemp, Franz J., Lau, Keith, Ernst, Matthias, Rakic, Andrea, Sikdar, Saif, Rajwani, Jahanara, Naumenko, Victor, Balce, Dale R., Ewanchuk, Ben W., Tailor, Pankaj, Yates, Robin M., Jenne, Craig, Gafuik, Chris, Mahoney, Douglas J.

“…Second mitochondrial activator of caspase (Smac)-mimetic compounds and oncolytic viruses were developed to kill cancer cells directly. However, Smac-mimetic…”
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Feed for Thought: Factors Predicting Public Support for Funding and Labeling Preferences of Alternative Aquafeed by Ho, Shirley S., Tan, Wenqi, Chuah, Agnes S. F., Chua, Pearlyn Y. Y., Lau, Keith X. L., Chan, Joshua Z. A.

“…Alternative aquafeed is currently being researched as a sustainable and environmentally friendly way to bolster aquaculture production, which plays an integral…”
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Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients by Lau, Keith CK, Joshi, Shivali S., Gao, Shan, Giles, Elizabeth, Swidinsky, Ken, van Marle, Guido, Bathe, Oliver F., Urbanski, Stefan J., Terrault, Norah A., Burak, Kelly W., Osiowy, Carla, Coffin, Carla S.

“…The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly driven by viral integration and specific oncogenic HBV variants…”
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Immune-Based Therapy for Hospitalized Patients With COVID-19 and Risk of Secondary Infections: A Systematic Review and Meta-analysis by Kabbani, Dima, Sonpar, Ashlesha, Weyant, Benson, Lau, Keith C K, Robbins, Mark, Campbell, Sandra, Doucette, Karen, Abraldes, Juan G, Lotfi, Tamara, Chaktoura, Marlene, Akl, Elie A, Cervera, Carlos

“…Immune-based therapies are standard-of-care treatment for coronavirus disease 2019 (COVID-19) patients requiring hospitalization. However, safety concerns…”
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Severe Ethanol Poisoning Among United States College Fraternity Pledges by Ing, Todd S, Sam, Armen, Tang, Hon-Lok, Lau, Keith K

“…Hazing is a longstanding tradition in university and college fraternities. This practice often uses alcohol as a penalty during hazing rituals, resulting in…”
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Chinese pediatricians face a crisis: reform is coming by Lau, Keith K, Chow, Chun-Bong, Chiu, Man-Chun

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Transition care in Hong Kong by Lau, K K

“…The main objective of the transition from paediatric to adult health care services is to ensure that all adolescents continue to receive coordinated care after…”
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Reversal of New, Factor-specific Oral Anticoagulants by rFVIIa, Prothrombin Complex Concentrate and Activated Prothrombin Complex Concentrate: A Review of Animal and Human Studies by Lee, Frank M.H, Chan, Anthony K.C, Lau, Keith K, Chan, Howard H

“…Abstract Introduction Recombinant activated factor VII (rFVIIa), prothrombin complex concentrate (PCC) and activated PCC (aPCC) are three non-specific…”
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Neonatal Renal Vein Thrombosis: Review of the English-Language Literature Between 1992 and 2006 by Lau, Keith K, Stoffman, Jayson M, Williams, Suzane, McCusker, Patricia, Brandao, Leonardo, Patel, Sanjay, Chan, Anthony K.C, Canadian Pediatric Thrombosis and Hemostasis Network

“…Renal vein thrombosis is a complication that occurs in neonates with various underlying risk factors. It carries a grave prognosis for affected kidneys…”
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Neonatal renal vein thrombosis by Brandão, Leonardo R, Simpson, Ewurabena A, Lau, Keith K

“…Summary Neonatal renal vein thrombosis (RVT) continues to pose significant challenges for pediatric hematologists and nephrologists. The precise mechanism for…”
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