Search Results - "Lau, Derrick"

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis by Márquez, Chantal L, Lau, Derrick, Walsh, James, Shah, Vaibhav, McGuinness, Conall, Wong, Andrew, Aggarwal, Anupriya, Parker, Michael W, Jacques, David A, Turville, Stuart, Böcking, Till

“…Uncoating of the metastable HIV-1 capsid is a tightly regulated disassembly process required for release of the viral cDNA prior to nuclear import. To…”
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Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA by Yoh, Sunnie M., Mamede, João I., Lau, Derrick, Ahn, Narae, Sánchez-Aparicio, Maria T., Temple, Joshua, Tuckwell, Andrew, Fuchs, Nina V., Cianci, Gianguido C., Riva, Laura, Curry, Heather, Yin, Xin, Gambut, Stéphanie, Simons, Lacy M., Hultquist, Judd F., König, Renate, Xiong, Yong, García-Sastre, Adolfo, Böcking, Till, Hope, Thomas J., Chanda, Sumit K.

“…We have previously described polyglutamine-binding protein 1 (PQBP1) as an adapter required for the cyclic GMP-AMP synthase (cGAS)-mediated innate response to…”
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Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein by Leitão, André D. G., Rudolffi-Soto, Paulina, Chappard, Alexandre, Bhumkar, Akshay, Lau, Derrick, Hunter, Dominic J. B., Gambin, Yann, Sierecki, Emma

“…The aggregation of alpha-synuclein (α-SYN) follows a cascade of oligomeric, prefibrillar and fibrillar forms, culminating in the formation of Lewy Bodies (LB),…”
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Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A by Peng, Wang, Shi, Jiong, Márquez, Chantal L, Lau, Derrick, Walsh, James, Faysal, K M Rifat, Byeon, Chang H, Byeon, In-Ja L, Aiken, Christopher, Böcking, Till

“…Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to…”
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Negative Staining Transmission Electron Microscopy of HIV Viral Particles Permeabilized with PFO and Capsid Stabilized with IP6 by Lau, Derrick, Márquez, Chantal L, Parker, Michael W, Böcking, And Till

“…The human immunodeficiency virus 1 (HIV-1) consists of a viral membrane surrounding the conical capsid. The capsid is a protein container assembled from…”
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Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro by Márquez, Chantal L, Lau, Derrick, Walsh, James, Faysal, K M Rifat, Parker, Michael W, Turville, Stuart G, Böcking, Till

“…The stability of the HIV-1 capsid and the spatiotemporal control of its disassembly, a process called uncoating, need to be finely tuned for infection to…”
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Resection of multifocal non–small cell lung cancer when the bronchioloalveolar subtype is involved by Roberts, Peter F, Straznicka, Michaela, Lara, Primo N, Lau, Derrick H, Follette, David M, Gandara, David R, Benfield, John R

“…Bronchioloalveolar lung cancer is commonly multifocal and can also present with other non–small cell types. The staging and treatment of multifocal non–small…”
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Integration of Novel Therapeutics into Combined Modality Therapy of Locally Advanced Non–Small Cell Lung Cancer by Gandara, David, Narayan, Samir, Lara, Jr, Primo N, Goldberg, Zelanna, Davies, Angela, Lau, Derrick H M, Mack, Philip, Gumerlock, Paul, Vijayakumar, Srinivasan

“…Novel therapeutic agents (NTA) directed against a wide array of newly described molecular targets are now entering clinical investigation, many in the…”
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Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma : Carboplatin and gemcitabine followed by paclitaxel by EDELMAN, Martin J, GANDARA, David R, LAU, Derrick H. M, LARA, Primo, LAUDER, I. Jun, TRACY, Deborah

“…The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell lung…”
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A patient-centered evaluation of a novel medical student-based patient navigation program by Wilson, Jeremy, Lau, Derrick, Kristoferson, Eva, Ginzler, Ellen, Kabani, Naureen

“…Understand the patient experience of a pilot medical student-based patient navigator (PN) program. (2) Assess areas of improvement for further development as a…”
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Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients by Bhumkar, Akshay, Magnan, Chloe, Lau, Derrick, Jun, Eugene Soh Wei, Dzamko, Nicolas, Gambin, Yann, Sierecki, Emma

“…α‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect…”
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Updates on the Molecular Basis of Photoaging in All Skin Types by Gollogly, Jessica Mineroff, Nguyen, Julie K, Lau, Derrick, Austin, Evan, Jagdeo, Jared

“…Photoaging is a complex, ongoing process that clinically manifests as cutaneous rhytides, atrophy, laxity, dyspigmentation, telangiectasias, roughness, and…”
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Single Molecule Fingerprinting Reveals Different Amplification Properties of α‑Synuclein Oligomers and Preformed Fibrils in Seeding Assay by Lau, Derrick, Magnan, Chloé, Hill, Kathryn, Cooper, Antony, Gambin, Yann, Sierecki, Emma

“…The quantification of α-synuclein aggregates has emerged as a promising biomarker for synucleinopathies. Assays that amplify and detect such aggregates have…”
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Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders by Lau, Derrick, Walsh, James C, Mousapasandi, Amir, Ariotti, Nicholas, Shah, Vaibhav B, Turville, Stuart, Jacques, David A, Böcking, Till

“…The human immunodeficiency virus (HIV) capsid is a cone-shaped capsule formed from the viral capsid protein (CA), which is arranged into a lattice of hexamers…”
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Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV‑1 Capsid Tubes by Lau, Derrick, Walsh, James C, Peng, Wang, Shah, Vaibhav B, Turville, Stuart, Jacques, David A, Böcking, Till

“…The human immunodeficiency virus 1 (HIV-1) capsid serves as a binding platform for proteins and small molecules from the host cell that regulate various steps…”
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Single-Molecule Fingerprinting Reveals Different Growth Mechanisms in Seed Amplification Assays for Different Polymorphs of α‑Synuclein Fibrils by Lau, Derrick, Tang, Yuan, Kenche, Vijaya, Copie, Thomas, Kempe, Daryan, Jary, Eve, Graves, Noah J., Biro, Maté, Masters, Colin L., Dzamko, Nicolas, Gambin, Yann, Sierecki, Emma

“…α-Synuclein (αSyn) aggregates, detected in the biofluids of patients with Parkinson’s disease (PD), have the ability to catalyze their own aggregation, leading…”
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Rapid HIV‑1 Capsid Interaction Screening Using Fluorescence Fluctuation Spectroscopy by Lau, Derrick, Walsh, James C, Dickson, Claire F, Tuckwell, Andrew, Stear, Jeffrey H, Hunter, Dominic J. B, Bhumkar, Akshay, Shah, Vaibhav, Turville, Stuart G, Sierecki, Emma, Gambin, Yann, Böcking, Till, Jacques, David A

“…The HIV capsid is a multifunctional protein capsule that mediates the delivery of the viral genetic material into the nucleus of the target cell. Host cell…”
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Single‐Molecule Counting Coupled to Rapid Amplification Enables Detection of α‐Synuclein Aggregates in Cerebrospinal Fluid of Parkinson's Disease Patients by Bhumkar, Akshay, Magnan, Chloe, Lau, Derrick, Jun, Eugene Soh Wei, Dzamko, Nicolas, Gambin, Yann, Sierecki, Emma

“…α‐Synuclein aggregation is a hallmark of Parkinson's disease and a promising biomarker for early detection and assessment of disease progression. The prospect…”
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Prion ‐ like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ? by O'Carroll, Ailis, Ve, Thomas, Lau, Derrick, Giles, Nichole, Moustaqil, Mehdi, Bhumkar, Akshay, Hunter, Dominic, Kobe, Bostjan, Boecking, Till, Sierecki, Emma, Gambin, Yann

“…Abstract only The innate immune system uses a multitude of receptors such as Toll‐like Receptors and Nod‐like Receptors to sense pathogens and danger signals…”
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Sequential combination chemotherapy in patients with advanced nonsmall cell lung carcinoma by Edelman, Martin J., Gandara, David R., Lau, Derrick H. M., Lara, Primo, Lauder, I. Jun, Tracy, Deborah

“…BACKGROUND The objective of this Phase II study was to evaluate the concept of sequential chemotherapy in the treatment of patients with advanced nonsmall cell…”
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