Search Results - "Lau, Clara B.S."

Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms by Or, Penelope M.Y., Lam, Francis F.Y., Kwan, Y.W., Cho, C.H., Lau, C.P., Yu, H., Lin, G., Lau, Clara B.S., Fung, K.P., Leung, P.C., Yeung, John H.K.

“…The present study investigated the effects of Radix Astragali (RA) and Radix Rehmanniae (RR), the major components of an anti-diabetic foot ulcer herbal…”
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In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine by Wang, Wenyi, Hui, Patrick C.L., Wat, Elaine, Ng, Frency S.F., Kan, Chi-Wai, Wang, Xiaowen, Wong, Eric C.W., Hu, Huawen, Chan, Ben, Lau, Clara B.S., Leung, Ping-Chung

“…[Display omitted] •P407/CMCs composite was fabricated.•pH and temperature affect its in vitro drug release behavior.•Diffusional release from P407/CMCs follows…”
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Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase by Chan, Ben C.L., Ip, Margaret, Gong, H., Lui, S.L., See, Raymond H., Jolivalt, Claude, Fung, K.P., Leung, P.C., Reiner, Neil E., Lau, Clara B.S.

“…Increasing prevalence of methicillin-resistant Staphylococcus aureus (MRSA) worldwide with limited therapeutic options is a growing public health concern…”
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Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa by Yue, Grace G.L., Chan, Ben C.L., Hon, Po-Ming, Lee, Mavis Y.H., Fung, Kwok-Pui, Leung, Ping-Chung, Lau, Clara B.S.

“…The rhizome of Curcuma longa (CL) has been commonly used in Asia as a potential candidate for the treatment of different diseases, including inflammatory…”
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Palladium-Catalyzed Arylation of Carbasugars Enables the Discovery of Potent and Selective SGLT2 Inhibitors by Ng, Wai-Lung, Lau, Kit-Man, Lau, Clara B.-S., Shing, Tony K. M.

“…Selective inhibition of the transporter protein sodium‐glucose cotransporter 2 (SGLT2) has emerged as a promising way to control blood glucose level in…”
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Inhibition of intestinal and renal Na +-glucose cotransporter by naringenin by Li, Jian Mei, Che, Chun Tao, Lau, Clara B.S., Leung, Po Sing, Cheng, Christopher H.K.

“…Reduction in glucose uptake constitutes a possible means of controlling diabetic hyperglycemia. Using purified intestinal brush border membrane vesicles and…”
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The role of turmerones on curcumin transportation and P-glycoprotein activities in intestinal Caco-2 cells by Yue, Grace G L, Cheng, Sau-Wan, Yu, Hua, Xu, Zi-Sheng, Lee, Julia K M, Hon, Po-Ming, Lee, Mavis Y H, Kennelly, Edward J, Deng, Gary, Yeung, Simon K, Cassileth, Barrie R, Fung, Kwok-Pui, Leung, Ping-Chung, Lau, Clara B S

“…The rhizome of Curcuma longa (turmeric) is often used in Asia as a spice and as a medicine. Its most well-studied component, curcumin, has been shown to…”
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Design, Syntheses, and SAR Studies of Carbocyclic Analogues of Sergliflozin as Potent Sodium-Dependent Glucose Cotransporter 2 Inhibitors by Shing, Tony K. M., Ng, Wai-Lung, Chan, Judy Y.-W., Lau, Clara B.-S.

“…Combating diabetes: A small‐molecule carbohydrate mimic, pseudo‐sergliflozin, was synthesized effectively by a regio‐ and stereoselective allylic substitution…”
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Anti-tumor and anti-osteolysis effects of the metronomic use of zoledronic acid in primary and metastatic breast cancer mouse models by Luo, Ke-Wang, Ko, Chun-Hay, Yue, Grace G.L, Lee, Michelle Y.Y, Siu, Wing-Sum, Lee, Julia K.M, Shum, Wai-Ting, Fung, Kwok-Pui, Leung, Ping-Chung, Li, Gang, Evdokiou, Andreas, Lau, Clara B.S

“…Highlights • Metronomic ZOL on tumor growth and osteolysis in breast cancer mice were studied. • Metronomic ZOL (zoledronic acid) resulted in a significant…”
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Comparative studies on the immunomodulatory and antitumor activities of the different parts of fruiting body of Ganoderma lucidum and Ganoderma spores by Yue, Grace G.L, Fung, Kwok-Pui, Leung, Ping-Chung, Lau, Clara B.S

“…Ganoderma lucidum (GL, Lingzhi) has been suggested as a candidate for immunomodulation and cancer treatment. The present study aimed at comparing the different…”
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A bio-activity guided in vitro pharmacokinetic method to improve the quality control of Chinese medicines, application to Si Wu Tang by Wang, Ling, Wang, Zhijun, Wo, Siukwan, Lau, Clara B.S., Chen, Xiao, Huang, Min, Lee, Vincent H.L., Chow, Moses S.S., Zuo, Zhong

“…The purpose of this study was to demonstrate the feasibility of using a bio-activity guided in vitro pharmacokinetic (BAPK) method in identifying relevant…”
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Synthesis of chiral hydroxylated enones as potential anti-tumor agents by Shing, Tony K.M., Wu, Ho T., Kwok, H.F., Lau, Clara B.S.

“…A series of chiral hydroxylated enones were synthesized as COTC ether analogues to investigate the structural features required for optimal and selective…”
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Search for antimycobacterial constituents from a Tibetan medicinal plant, Gentianopsis paludosa by Yeung, Ming-Fai, Lau, Clara B.S, Chan, Raphael C.Y, Zong, Yuying, Che, Chun-Tao

“…From the whole plant of Gentianopsis paludosa seven compounds were isolated and identified to be 1,7-dihydroxy-3,8-dimethoxyxanthone (1),…”
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Differential effect of Coriolus versicolor (Yunzhi) extract on cytokine production by murine lymphocytes in vitro by Ho, C.Y., Lau, Clara B.S., Kim, C.F., Leung, K.N., Fung, K.P., Tse, T.F., Chan, Helen H.L., Chow, Moses S.S.

“…Being one of the commonly used Chinese medicinal herbs, Coriolus versicolor (CV), also named as Yunzhi, was known to possess both anti-tumor and…”
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An outcomes-based approach to curriculum development in pharmacy by Ho, Susan S S, Kember, David, Lau, Clara B S, Au Yeung, Mary Y M, Leung, Doris Y P, Chow, Moses S S

“…To implement an outcomes-based approach to pharmacy curriculum development. Desired learning outcomes were identified; course content, learning activities, and…”
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Dual-functional transdermal drug delivery system with controllable drug loading based on thermosensitive poloxamer hydrogel for atopic dermatitis treatment by Wang, Wenyi, Wat, Elaine, Hui, Patrick C. L., Chan, Ben, Ng, Frency S. F., Kan, Chi-Wai, Wang, Xiaowen, Hu, Huawen, Wong, Eric C. W., Lau, Clara B. S., Leung, Ping-Chung

“…The treatment of atopic dermatitis (AD) has long been viewed as a problematic issue by the medical profession. Although a wide variety of complementary…”
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Development of thermosensitive hydrogel containing methylene blue for topical antimicrobial photodynamic therapy by Leung, Brian, Dharmaratne, Priyanga, Yan, Wei, Chan, Ben C.L., Lau, Clara B.S., Fung, Kwok-Pui, Ip, Margaret, Leung, Sharon S.Y.

“…Due to the emergence of antibiotic resistance, antimicrobial photodynamic therapy (aPDT) has recently been demonstrated as a promising alternative to…”
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Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin Inflammation by Tsang, Miranda S M, Jiao, Delong, Chan, Ben C L, Hon, Kam-Lun, Leung, Ping C, Lau, Clara B S, Wong, Eric C W, Cheng, Ling, Chan, Carmen K M, Lam, Christopher W K, Wong, Chun K

“…Atopic dermatitis (AD) is a common allergic skin disease, characterized by dryness, itchiness, thickening and inflammation of the skin. Infiltration of…”
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Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase by Chan, Ben C.L., Ip, Margaret, Lau, Clara B.S., Lui, S.L., Jolivalt, Claude, Ganem-Elbaz, Carine, Litaudon, Marc, Reiner, Neil E., Gong, Huansheng, See, Raymond H., Fung, K.P., Leung, P.C.

“…Baicalein (a) could reverse the ciprofloxacin resistance of MRSA possibly by inhibiting the NorA efflux pump in vitro (b). The inhibition of MRSA PK (c) by…”
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Jaboticabin and Related Polyphenols from Jaboticaba (Myrciaria cauliflora) with Anti-inflammatory Activity for Chronic Obstructive Pulmonary Disease by Zhao, Da-Ke, Shi, Ya-Na, Petrova, Vanya, Yue, Grace G. L, Negrin, Adam, Wu, Shi-Biao, D’Armiento, Jeanine M, Lau, Clara B. S, Kennelly, Edward J

“…Myrciaria cauliflora (jaboticaba) is an edible fruit common in Brazil that has been used for treating respiratory diseases, including chronic tonsillitis and…”
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