Search Results - "Lau, Alice L"

Potential function for the Huntingtin protein as a scaffold for selective autophagy by Ochaba, Joseph, Lukacsovich, Tamás, Csikos, George, Zheng, Shuqiu, Margulis, Julia, Salazar, Lisa, Mao, Kai, Lau, Alice L., Yeung, Sylvia Y., Humbert, Sandrine, Saudou, Frédéric, Klionsky, Daniel J., Finkbeiner, Steven, Zeitlin, Scott O., Marsh, J. Lawrence, Housman, David E., Thompson, Leslie M., Steffan, Joan S.

“…Significance The normal function of the Huntingtin (HTT) protein is emerging. Here we report that selective autophagy requires an intact HTT protein in…”
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TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease by Zhao, Xiaobei, Chen, Xu-Qiao, Han, Eugene, Hu, Yue, Paik, Paul, Ding, Zhiyong, Overman, Julia, Lau, Alice L., Shahmoradian, Sarah H., Chiu, Wah, Thompson, Leslie M., Wu, Chengbiao, Mobley, William C.

“…Corticostriatal atrophy is a cardinal manifestation of Huntington’s disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein…”
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Calcium Dynamics in Astrocytes During Cell Injury by Wakida, Nicole M., Gomez-Godinez, Veronica, Li, Huayan, Nguyen, Jessica, Kim, Edward K., Dynes, Joseph L., Othy, Shivashankar, Lau, Alice L., Ding, Peng, Shi, Linda, Carmona, Christopher, Thompson, Leslie M., Cahalan, Michael D., Berns, Michael W.

“…The changes in intracellular calcium concentration ([Ca 2+ ]) following laser-induced cell injury in nearby cells were studied in primary mouse astrocytes…”
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice by Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, Alice L, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Kedaigle, Amanda J, Gipson, Theresa A, Yildirim, Ferah, Ng, Christopher W, Milani, Pamela, Housman, David E, Fraenkel, Ernest, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N

“…The Huntington's disease (HD) induced pluripotent stem cell (iPSC) consortium describe the combined use of differentiated patient-derived iPSCs and systems…”
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Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization by Sanchez, Isabella I, Nguyen, Thai B, England, Whitney E, Lim, Ryan G, Vu, Anthony Q, Miramontes, Ricardo, Byrne, Lauren M, Markmiller, Sebastian, Lau, Alice L, Orellana, Iliana, Curtis, Maurice A, Faull, Richard Lewis Maxwell, Yeo, Gene W, Fowler, Christie D, Reidling, Jack C, Wild, Edward J, Spitale, Robert C, Thompson, Leslie M

“…Chronic cellular stress associated with neurodegenerative disease can result in the persistence of stress granule (SG) structures, membraneless organelles that…”
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IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome by Thompson, Leslie Michels, Aiken, Charity T, Kaltenbach, Linda S, Agrawal, Namita, Illes, Katalin, Khoshnan, Ali, Martinez-Vincente, Marta, Arrasate, Montserrat, O'Rourke, Jacqueline Gire, Khashwji, Hasan, Lukacsovich, Tamas, Zhu, Ya-Zhen, Lau, Alice L, Massey, Ashish, Hayden, Michael R, Zeitlin, Scott O, Finkbeiner, Steven, Green, Kim N, LaFerla, Frank M, Bates, Gillian, Huang, Lan, Patterson, Paul H, Lo, Donald C, Cuervo, Ana Maria, Marsh, J. Lawrence, Steffan, Joan S

“…Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and…”
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Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins by Fote, Gianna M, Eapen, Vinay V, Lim, Ryan G, Yu, Clinton, Salazar, Lisa, McClure, Nicolette R, McKnight, Jharrayne, Nguyen, Thai B, Heath, Marie C, Lau, Alice L, Villamil, Mark A, Miramontes, Ricardo, Kratter, Ian H, Finkbeiner, Steven, Reidling, Jack C, Paulo, Joao A, Kaiser, Peter, Huang, Lan, Housman, David E, Thompson, Leslie M, Steffan, Joan S

“…Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for…”
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IKKβ slows Huntington’s disease progression in R6/1 mice by Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y., Lau, Alice L., Hernandez, Sarah, Lim, Ryan G., Casale, Malcolm, Neel, Michael J., Monuki, Edwin S., Reidling, Jack, Housman, David E., Thompson, Leslie M., Steffan, Joan S.

“…Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions…”
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Diminished LC3-Associated Phagocytosis by Huntington's Disease Striatal Astrocytes by Wakida, Nicole M, Lau, Alice L, Nguyen, Jessica, Cruz, Gladys Mae S, Fote, Gianna M, Steffan, Joan S, Thompson, Leslie M, Berns, Michael W

“…In recent years the functions of astrocytes have shifted from conventional supportive roles to also include active roles in altering synapses and engulfment of…”
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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models by Franich, Nicholas R, Basso, Manuela, André, Emily A, Ochaba, Joseph, Kumar, Amit, Thein, Soe, Fote, Gianna, Kachemov, Marketta, Lau, Alice L, Yeung, Sylvia Y, Osmand, Alexander, Zeitlin, Scott O, Ratan, Rajiv R, Thompson, Leslie M, Steffan, Joan S

“…Huntington's disease (HD) is a progressive neurodegenerative disorder associated with aging, caused by an expanded polyglutamine (polyQ) repeat within the…”
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Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization by Sanchez, Isabella I, Nguyen, Thai B, England, Whitney E, Lim, Ryan G, Vu, Anthony Q, Miramontes, Ricardo, Byrne, Lauren M, Markmiller, Sebastian, Lau, Alice L, Orellana, Iliana, Curtis, Maurice A, Faull, Richard Lewis Maxwell, Yeo, Gene W, Fowler, Christie D, Reidling, Jack C, Wild, Edward J, Spitale, Robert C, Thompson, Leslie M

“…Chronic cellular stress associated with neurodegenerative disease can result in the persistence of stress granule (SG) structures, membraneless organelles that…”
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Selective radiolabeling of cell surface proteins to a high specific activity by Thompson, James A, Lau, Alice L, Cunningham, Dennis D

“…A procedure was developed for selective radiolabeling of membrane proteins on cells to higher specific activities than possible with available techniques. Cell…”
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Urinary excretion of zinc, copper and iron in the streptozotocin-diabetic rat by Lau, A L, Failla, M L

“…The influence of the chemically diabetic condition on urinary excretion of zinc, copper and iron was investigated. Male Sprague-Dawley rats were injected with…”
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Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases by Wagner, Steven L, Van Nostrand, William E, Lau, Alice L, Cunningham, Dennis D

“…Protease nexin 1 (PN-1) is a protease inhibitor secreted by cultured fibroblasts that forms complexes with certain serine proteases; the complexes bind back to…”
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Injury‐Related Factors and Conditions Down‐Regulate the Thrombin Receptor (PAR‐1) in a Human Neuronal Cell Line by Weinstein, Jonathan R., Lau, Alice L., Brass, Lawrence F., Cunningham, Dennis D.

“…: Previous studies have demonstrated that thrombin can induce potent effects on neural cell morphology, biochemistry, and viability. Nearly all of these…”
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Protease Nexin-1, an Antithrombin with Neurite Outgrowth Activity, is Reduced in Alzheimer Disease by Wagner, Steven L., Geddes, James W., Cotman, Carl W., Lau, Alice L., Gurwitz, David, Isackson, Paul J., Cunningham, Dennis D.

“…Protease nexin-1 (PN-1) is a cell-secreted protein that inhibits certain proteases, particularly thrombin, by forming SDS-stable complexes with the catalytic…”
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Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts by Guttridge, D.C., Lau, A.L., Cunningham, D.D.

“…Thrombin participates in several regulatory events following injury as a result of its effects on blood coagulation and cell migration, proliferation, and…”
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Inhibitors of urokinase and thrombin in cultured neural cells by Wagner, S L, Lau, A L, Nguyen, A, Mimuro, J, Loskutoff, D J, Isackson, P J, Cunningham, D D

“…Recent studies have suggested important roles for certain proteases and protease inhibitors in the growth and development of the CNS. In the present studies,…”
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