Search Results - "Lau, Alan W."

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer by Gasser, Jessica A., Inuzuka, Hiroyuki, Lau, Alan W., Wei, Wenyi, Beroukhim, Rameen, Toker, Alex

“…Oncogenic mutations in PIK3CA, the gene encoding the catalytic subunit of phosphoinositide 3-kinase (PI3K), occur with high frequency in breast cancer. The…”
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Acetylation-Dependent Regulation of Skp2 Function by Inuzuka, Hiroyuki, Gao, Daming, Finley, Lydia W.S., Yang, Wen, Wan, Lixin, Fukushima, Hidefumi, Chin, Y. Rebecca, Zhai, Bo, Shaik, Shavali, Lau, Alan W., Wang, Zhiwei, Gygi, Steven P., Nakayama, Keiko, Teruya-Feldstein, Julie, Toker, Alex, Haigis, Marcia C., Pandolfi, Pier Paolo, Wei, Wenyi

“…Aberrant Skp2 signaling has been implicated as a driving event in tumorigenesis. Although the underlying molecular mechanisms remain elusive, cytoplasmic Skp2…”
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Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase by Min, Sang-Hyun, Lau, Alan W., Lee, Tae Ho, Inuzuka, Hiroyuki, Wei, Shuo, Huang, Pengyu, Shaik, Shavali, Lee, Daniel Yenhong, Finn, Greg, Balastik, Martin, Chen, Chun-Hau, Luo, Manli, Tron, Adriana E., DeCaprio, James A., Zhou, Xiao Zhen, Wei, Wenyi, Lu, Kun Ping

“…Fbw7 is the substrate recognition component of the Skp1-Cullin-F-box (SCF)-type E3 ligase complex and a well-characterized tumor suppressor that targets…”
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A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit by Blobel, Gerd A., Kadauke, Stephan, Wang, Eric, Lau, Alan W., Zuber, Johannes, Chou, Margaret M., Vakoc, Christopher R.

“…Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify…”
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SCF-Mediated Cdh1 Degradation Defines a Negative Feedback System that Coordinates Cell-Cycle Progression by Fukushima, Hidefumi, Ogura, Kohei, Wan, Lixin, Lu, Ying, Li, Victor, Gao, Daming, Liu, Pengda, Lau, Alan W., Wu, Tao, Kirschner, Marc W., Inuzuka, Hiroyuki, Wei, Wenyi

“…Proper cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key regulators by the anaphase-promoting complex (APC) and…”
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The two faces of FBW7 in cancer drug resistance by Wang, Zhiwei, Fukushima, Hidefumi, Gao, Daming, Inuzuka, Hiroyuki, Wan, Lixin, Lau, Alan W., Liu, Pengda, Wei, Wenyi

“…Chemotherapy is an important therapeutic approach for cancer treatment. However, drug resistance is an obstacle that often impairs the successful use of…”
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SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction by Fukushima, Hidefumi, Matsumoto, Akinobu, Inuzuka, Hiroyuki, Zhai, Bo, Lau, Alan W., Wan, Lixin, Gao, Daming, Shaik, Shavali, Yuan, Min, Gygi, Steven P., Jimi, Eijiro, Asara, John M., Nakayama, Keiko, Nakayama, Keiichi I., Wei, Wenyi

“…The NFκB/Rel family of proteins play critical roles in a variety of cellular processes. Thus, their physiological activation is tightly controlled. Recently,…”
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adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway by Lau, Alan W, Chou, Margaret M

“…The ADP-ribosylation factor 6 (Arf6) GTPase functions as a key regulator of endocytic trafficking, participating in clathrin-independent endocytosis in most…”
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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction by Inuzuka, Hiroyuki, Shaik, Shavali, Onoyama, Ichiro, Gao, Daming, Tseng, Alan, Maser, Richard S, Zhai, Bo, Wan, Lixin, Gutierrez, Alejandro, Lau, Alan W, Xiao, Yonghong, Christie, Amanda L, Aster, Jon, Settleman, Jeffrey, Gygi, Steven P, Kung, Andrew L, Look, Thomas, Nakayama, Keiichi I, DePinho, Ronald A, Wei, Wenyi

“…The effective use of targeted therapy is highly dependent on the identification of responder patient populations. Loss of FBW7, which encodes a…”
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Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion by Erickson-Johnson, Michele R, Chou, Margaret M, Evers, Barbara R, Roth, Christopher W, Seys, Amber R, Jin, Long, Ye, Ying, Lau, Alan W, Wang, Xiaoke, Oliveira, Andre M

“…Nodular fasciitis (NF) is a relatively common mass-forming and self-limited subcutaneous pseudosarcomatous myofibroblastic proliferation of unknown…”
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Calcium/Calmodulin Regulates Ubiquitination of the Ubiquitin-specific Protease TRE17/USP6 by Shen, Chuanlu, Ye, Ying, Robertson, Sarah E., Lau, Alan W., Mak, Don-On D., Chou, Margaret M.

“…The TRE17 (USP6/TRE-2) oncogene induces tumorigenesis in both humans and mice. However, little is known regarding its regulation or mechanism of…”
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Mcl-1 ubiquitination and destruction by Inuzuka, Hiroyuki, Fukushima, Hidefumi, Shaik, Shavali, Liu, Pengda, Lau, Alan W, Wei, Wenyi

“…Loss of the Fbw7 tumor suppressor is common in diverse human cancer types, including T-Cell Acute Lymphoblastic Leukemia (T-ALL), although the mechanistic…”
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SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation by Lau, Alan W, Liu, Pengda, Inuzuka, Hiroyuki, Gao, Daming

“…The deacetylase SIRT1 regulates multiple biological processes including cellular metabolism and aging. Importantly, SIRT1 can also inactivate the p53 tumor…”
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Measuring forces in liver cutting: new equipment and experimental results by Chanthasopeephan, Teeranoot, Desai, Jaydev P, Lau, Alan C W

“…We are interested in modeling the liver cutting process as accurately as possible by determining the mechanical properties experimentally and developing a…”
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Modeling Soft-Tissue Deformation Prior to Cutting for Surgical Simulation: Finite Element Analysis and Study of Cutting Parameters by Chanthasopeephan, Teeranoot, Desai, Jaydev P., Lau, Alan C. W.

“…This paper presents an experimental study to understand the localized soft-tissue deformation phase immediately preceding crack growth as observed during the…”
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Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7 by Lau, Alan W, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Wan, Lixin, Liu, Pengda, Gao, Daming, Sun, Yi, Wei, Wenyi

“…Fbw7 and Cdh1 are substrate-recognition subunits of the SCF- and APC-type E3 ubiquitin ligases, respectively. There is emerging evidence suggesting that both…”
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TRE17/Ubiquitin-specific Protease 6 (USP6) Oncogene Translocated in Aneurysmal Bone Cyst Blocks Osteoblastic Maturation via an Autocrine Mechanism Involving Bone Morphogenetic Protein Dysregulation by Lau, Alan W., Pringle, Lashon M., Quick, Laura, Riquelme, Daisy N., Ye, Ying, Oliveira, Andre M., Chou, Margaret M.

“…Aneurysmal bone cyst (ABC) is a pediatric osseous tumor characterized by extensive destruction of the surrounding bone. The molecular mechanisms underlying its…”
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Acetylation‐dependent regulation of essential iPS‐inducing factors: a regulatory crossroad for pluripotency and tumorigenesis by Dai, Xiangpeng, Liu, Pengda, Lau, Alan W., Liu, Yueyong, Inuzuka, Hiroyuki

“…Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c‐Myc. However,…”
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SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction by INUZUKA, Hiroyuki, SHAIK, Shavali, YONGHONG XIAO, CHRISTIE, Amanda L, ASTER, Jon, SETTLEMAN, Jeffrey, GYGI, Steven P, KUNG, Andrew L, LOOK, Thomas, NAKAYAMA, Keiichi I, DEPINHO, Ronald A, WENYI WEI, ONOYAMA, Ichiro, DARNING GAO, TSENG, Alan, MASER, Richard S, BO ZHAI, LIXIN WAN, GUTIERREZ, Alejandro, LAU, Alan W

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Regulation of APCCdh1 E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7 by Lau, Alan W, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Wan, Lixin, Liu, Pengda, Gao, Daming, Sun, Yi, Wei, Wenyi

“…Fbw7 and Cdh1 are substrate-recognition subunits of the SCF- and APC-type E3 ubiquitin ligases, respectively. There is emerging evidence suggesting that both…”
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